Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/36056
Title: Factors associated with localization of tuberculosis disease among patients in a high burden country: A health facility-based comparative study in Ethiopia
Authors: Taye, H
Alemu, K
Mihret, A
WOOD, James 
SHKEDY, Ziv 
Berg , S
Aseffa, A
Issue Date: 2021
Publisher: ELSEVIER
Source: JOURNAL OF CLINICAL TUBERCULOSIS AND OTHER MYCOBACTERIAL DISEASES, 23 (Art N° 100231)
Abstract: Introduction: In contrast to most tuberculosis (TB) high burden countries, Ethiopia has for a long time reported a very high percentage of extra pulmonary TB (EPTB), which is also reflected in population based estimations reported by the World Health Organization (WHO). Particularly a steadily higher proportion of cervical tuberculous lymphadenitis (TBLN) has been described. Here we identify clinical and demographic factors associated with anatomic site of the TB disease.Method: A health facility based comparative study was conducted among TBLN and PTB patients who visited selected health facilities in Ethiopia during 2016 and 2017. Associated risk factors were identified through a multivariate logistic regression model using R-studio.Result: A total of 1,890 study participants, 427 TBLN and 1,463 PTB patients, were included. The mean age of TBLN patients (29 years +/- 14.4 SD) was lower than that of PTB cases (36 years +/- 15.0 SD). There were slightly more women diagnosed with TBLN (51.1%) while nearly 6 out of 10 male patients were diagnosed with PTB (58.9%). Most significantly, younger age groups (<15 Years) were more likely to develop cervical TBLN than older people (>56 years), with an AOR of 9.76 (95% CI: 4.87, 19.56). The odds of cervical TBLN among women [1.69 (1.30, 2.20)] was higher than that for men. In addition, adjusted estimates suggested that, compared with PTB, renal diseases [3.41 (1.29, 9.02)] and the presence of other concomitant chronic illness [1.61 (1.23, 2.09)] had a significant association with TBLN.Conclusion: Generally, the risk of developing a particular form of TB disease is usually associated with demographic and medical history of an infected individual. Hence, the current symptom based screening, which primarily rely on chronic cough in many countries, may lead to missing significant portions of TBLN cases.
Keywords: Tuberculosis;Clinical disease category;Associated factors
Document URI: http://hdl.handle.net/1942/36056
ISSN: 2405-5794
e-ISSN: 2405-5794
DOI: 10.1016/j.jctube.2021.100231
ISI #: 000658434400016
Rights: 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Category: A1
Type: Journal Contribution
Validations: vabb 2023
Appears in Collections:Research publications

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