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Title: | Impact of Proton Pump Inhibitors on Efficacy of Antiplatelet Strategies With Ticagrelor or Aspirin After Percutaneous Coronary Intervention | Authors: | Ono, Masafumi Onuma, Yoshinobu Kawashima, Hideyuki Hara, Hironori Gao, Chao Wang, Rutao O'Leary, Neil Garg, Scot Juni, Peter Hamm, Christian Valgimigli, Marco Windecker, Stephan VRANCKX, Pascal Deliargyris, Efthymios Bhatt, Deepak Storey, Robert Serruys, Patrick |
Issue Date: | 2021 | Publisher: | ELSEVIER SCIENCE INC | Source: | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 78 (19) , p. B82 -B83 | Abstract: | BACKGROUND A new method based on the principle of thermodilu-tion has been validated to quantify volumetric coronary absolute flow. This technique requires an intracoronary infusion of saline solution at room temperature through a dedicated catheter that induces steady-state maximal hyperemia at a flow rate 20 mL/min. Our aim was to compare fractional flow reserve (FFR) using intracoronary saline infusion (FFRsaline) versus conventional FFR with adenosine (FFRadenosine) METHODS In 118 patients with suspected coronary disease in 3 centers , FFRsaline and FFRadenosine were measured. Adenosine endo-venous infusion was set at a mean rate of 165 mg/kg/min (range 150-180) RESULTS The mean value of FFRsaline was 0.89 AE 0.07 and of FFRadenosine 0.90 AE 0.05; and the mean difference between both methods was 0.03 AE 0.03, which can be attributed to the ray-flow catheter effect on the coronary flow. Both parameters showed good correlation (r ¼ 0.73; P < 0.01). FFRadenosine and FFRsaline were dichotomized (cutoff value 0.8) and FFRadenosine and FFRsaline were concordant in 93.3% of cases. Using the cutoff value of 0.75 the concordance was higher (98.5% of cases). Considering coronary vessel without coronary disease according to FFRadenosine, the concordance between both parameters was 99%. CONCLUSION FFRsaline and FFRadenosine showed good correlation. The concordance between both parameters showed a tendency to be higher in nondiseased vessels, suggesting that FFRsaline could be a useful adenosine-free index to defer coronary lesions. CATEGORIES IMAGING AND PHYSIOLOGY: Physiologic Lesion Assessment BACKGROUND Drug-eluting balloons (DEBs) are a feasible method of rapid delivery of drug to the vessel wall during a single balloon inflation without the need to leave a permanent implant. Their efficacy has been established for in-stent restenosis and small vessels but there are limited data for their use in bifurcation lesions. | Document URI: | http://hdl.handle.net/1942/36064 | ISSN: | 0735-1097 | e-ISSN: | 1558-3597 | ISI #: | WOS:000715526900186 | Category: | M | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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