Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/36142
Title: | Extracellular vesicle-associated small heat shock proteins as therapeutic agents in neurodegenerative diseases and beyond | Authors: | Wuyts, Charlotte IROBI, Joy VAN DEN BROEK, Bram |
Issue Date: | 2021 | Publisher: | ELSEVIER | Source: | ADVANCED DRUG DELIVERY REVIEWS, 179 (Art N° 114009) | Abstract: | Increasing evidence points towards using extracellular vesicles (EVs) as a therapeutic strategy in neurodegenerative diseases such as multiple sclerosis, Parkinson's, and Alzheimer's disease. EVs are nanosized carriers that play an essential role in intercellular communication and cellular homeostasis by transporting an active molecular cargo, including a large variety of proteins. Recent publications demonstrate that small heat shock proteins (HSPBs) exhibit a beneficial role in neurodegenerative diseases. Moreover, it is defined that HSPBs target the autophagy and the apoptosis pathway, playing a prominent role in chaperone activity and cell survival. This review elaborates on the therapeutic potential of EVs and HSPBs, in particular HSPB1 and HSPB8, in neurodegenerative diseases. We conclude that EVs and HSPBs positively influence neuroinflammation, central nervous system (CNS) repair, and protein aggregation in CNS disorders. Moreover, we propose the use of HSPB-loaded EVs as advanced nanocarriers for the future development of neurodegenerative disease therapies. (c) 2021 Elsevier B.V. All rights reserved. | Notes: | Irobi, J (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Diepenbeek, Belgium. joy.irobi@uhasselt.be |
Keywords: | Extracellular vesicles;Small heat shock proteins;Molecular chaperones;Neurodegeneration;CNS disorders;Neuroprotection | Document URI: | http://hdl.handle.net/1942/36142 | ISSN: | 0169-409X | e-ISSN: | 1872-8294 | DOI: | 10.1016/j.addr.2021.114009 | ISI #: | 000711678600007 | Rights: | 2021 Elsevier B.V. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Extracellular vesicle-associated small heat shock proteins as therapeutic agents in neurodegenerative diseases and beyond.pdf Restricted Access | Published version | 1.45 MB | Adobe PDF | View/Open Request a copy |
WEB OF SCIENCETM
Citations
12
checked on Oct 13, 2024
Page view(s)
28
checked on Aug 15, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.