Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/36158
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dc.contributor.authorMARTENS, Pieter-
dc.contributor.authorHERBOTS, Lieven-
dc.contributor.authorTimmermans, P-
dc.contributor.authorVERBRUGGE, Frederik-
dc.contributor.authorDENDALE, Paul-
dc.contributor.authorBorlaug, BA-
dc.contributor.authorVERWERFT, Jan-
dc.date.accessioned2021-12-13T14:02:36Z-
dc.date.available2021-12-13T14:02:36Z-
dc.date.issued2022-
dc.date.submitted2021-08-27T12:54:46Z-
dc.identifier.citationJournal of Cardiovascular Translational Research, 15 (1) , p. 116-130-
dc.identifier.urihttp://hdl.handle.net/1942/36158-
dc.description.abstractLittle data is available about the pathophysiological mechanisms of unexplained dyspnea and their clinical meaning. Consecutive patients with unexplained dyspnea underwent prospective standardized cardiopulmonary exercise testing with echocardiography (CPETecho). Patients were grouped as having normal exercise capacity (peak VO2 > 80% with respiratory exchange [RER] > 1.05), reduced exercise capacity (peak VO2 <= 80% with RER > 1.05), or a submaximal exercise test (RER <= 1.05). From 307 patients, 144 (47%) had normal and 116 (38%) reduced exercise capacity, and 47 (15%) had a submaximal exercise test. Patients with reduced versus normal exercise capacity had significantly more mechanisms for unexplained dyspnea (2.3 +/- 1.0 vs 1.5 +/- 1.0, respectively; p<0.001). Exercise PH (42%), low heart rate reserve (51%), low stroke volume reserve (38%), low diastolic reserve (18%), and peripheral muscle limitation (17%) were most common. Patients with more mechanisms for dyspnea displayed poorer peak VO2 and had an increased risk for cardiovascular hospitalization (p=0.002). Patients with unexplained dyspnea display multiple coexisting mechanisms for exercise intolerance, which relate to the severity of exercise limitation and risk of subsequent cardiovascular hospitalizations.-
dc.language.isoen-
dc.publisherSPRINGER-
dc.rightsThe Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021-
dc.subject.otherDyspnea-
dc.subject.otherHeart failure-
dc.subject.otherCardiopulmonary exercise testing-
dc.subject.otherPathophysiology-
dc.subject.otherExercise-induced pulmonary hypertension-
dc.titleCardiopulmonary Exercise Testing with Echocardiography to Identify Mechanisms of Unexplained Dyspnea-
dc.typeJournal Contribution-
dc.identifier.epage130-
dc.identifier.issue1-
dc.identifier.spage116-
dc.identifier.volume15-
local.bibliographicCitation.jcatA1-
local.publisher.placeONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1007/s12265-021-10142-8-
dc.identifier.pmid34110608-
dc.identifier.isi000659800300001-
local.provider.typeWeb of Science-
local.uhasselt.internationalyes-
item.accessRightsRestricted Access-
item.validationecoom 2022-
item.fulltextWith Fulltext-
item.contributorMARTENS, Pieter-
item.contributorHERBOTS, Lieven-
item.contributorTimmermans, P-
item.contributorVERBRUGGE, Frederik-
item.contributorDENDALE, Paul-
item.contributorBorlaug, BA-
item.contributorVERWERFT, Jan-
item.fullcitationMARTENS, Pieter; HERBOTS, Lieven; Timmermans, P; VERBRUGGE, Frederik; DENDALE, Paul; Borlaug, BA & VERWERFT, Jan (2022) Cardiopulmonary Exercise Testing with Echocardiography to Identify Mechanisms of Unexplained Dyspnea. In: Journal of Cardiovascular Translational Research, 15 (1) , p. 116-130.-
crisitem.journal.issn1937-5387-
crisitem.journal.eissn1937-5395-
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