Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/36271
Title: | Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant | Authors: | Fiesack, Simon Smits, Anne Rayyan, Maissa Allegaert, Karel ALLIET, Philippe Arts, Wim Bael, An Cornette, Luc De Guchtenaere, Ann De Mulder, Nele George, Isabel Henrion, Elisabeth Keiren, Kirsten Kreins, Nathalie RAES, Marc Philippet, Pierre Van Overmeire, Bart Van Winckel, Myriam Vlieghe, Vinciane Vandenplas, Yvan |
Issue Date: | 2021 | Publisher: | MDPI | Source: | NUTRIENTS, 13 (11) , (Art N° 4109) | Abstract: | Neonatal vitamin K prophylaxis is essential to prevent vitamin K deficiency bleeding (VKDB) with a clear benefit compared to placebo. Various routes (intramuscular (IM), oral, intravenous (IV)) and dosing regimens were explored. A literature review was conducted to compare vitamin K regimens on VKDB incidence. Simultaneously, information on practices was collected from Belgian pediatric and neonatal departments. Based on the review and these practices, a consensus was developed and voted on by all co-authors and heads of pediatric departments. Today, practices vary. In line with literature, the advised prophylactic regimen is 1 or 2 mg IM vitamin K once at birth. In the case of parental refusal, healthcare providers should inform parents of the slightly inferior alternative (2 mg oral vitamin K at birth, followed by 1 or 2 mg oral weekly for 3 months when breastfed). We recommend 1 mg IM in preterm < 32 weeks, and the same alternative in the case of parental refusal. When IM is perceived impossible in preterm < 32 weeks, 0.5 mg IV once is recommended, with a single additional IM 1 mg dose when IV lipids are discontinued. This recommendation is a step towards harmonizing vitamin K prophylaxis in all newborns. | Notes: | Vandenplas, Y (corresponding author), ZNA Queen Paola Childrens Hosp, Fac Med UA, Dept Pediat, B-2020 Antwerp, Belgium.; Vandenplas, Y (corresponding author), Vrije Univ Brussel VUB, UZ Bussel, KidZ Hlth Castle, B-1090 Brussels, Belgium. simon.fiesack@student.kuleuven.be; anne.smits@uzleuven.be; maissa.rayyan@uzleuven.be; karel.allegaert@uzleuven.be; wim.arts@zol.be; luc.cornette@azsintjan.be; dr.deguchtenaere@gmail.com; nele.demulder@uzbrussel.be; dr.isabelgeorge@gmail.com; elisabeth.henrion@chrsm.be; kirsten.keiren@hotmail.com; Nathalie.kreins@chc.be; pierre.philippet@chc.be; bart.vanovermeire@opgroeien.be; Myriam.VanWinckel@uzgent.be; Vinciane.vlieghe@huderf.be |
Keywords: | vitamin K; vitamin K deficiency bleeding; term; preterm; prophylaxis | Document URI: | http://hdl.handle.net/1942/36271 | e-ISSN: | 2072-6643 | DOI: | 10.3390/nu13114109 | ISI #: | WOS:000723830900001 | Rights: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant _ Enhanced Reader.pdf | Published version | 15.29 MB | Adobe PDF | View/Open |
WEB OF SCIENCETM
Citations
4
checked on Apr 30, 2024
Page view(s)
34
checked on Aug 10, 2022
Download(s)
6
checked on Aug 10, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.