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Title: | Follow-up testing of borderline SARS-CoV-2 patients by rRT-PCR allows early diagnosis of COVID-19 | Authors: | Boeckmans, J Cartuyvels , R HILKENS, Petra BRUCKERS, Liesbeth MAGERMAN, Koen WAUMANS, Luc Raymaekers, M |
Issue Date: | 2021 | Publisher: | ELSEVIER SCIENCE INC | Source: | Diagnostic microbiology and infectious disease, 100 (2) (Art N° 115350) | Abstract: | Detection of SARS-CoV-2 RNA in nasopharyngeal samples using the real-time reverse transcription polymer-ase chain reaction (rRT-PCR) is the gold standard for diagnosing COVID-19. Determination of SARS-CoV-2 RNA by rRT-PCR sometimes results in an inconclusive test result due to a high cycle threshold-value.We retrospectively analyzed 30,851 SARS-CoV-2 rRT-PCR test results. Borderline positivity was considered as the presence of <= 25 viral copies per milliliter, while no amplification was considered as a negative test result. Of all test results, 204 were answered as borderline, of which 107 were accompanied by a follow-up test within 96 hours. Of the 107 follow-up samples, 10 (9.35%) were found positive for SARS-CoV-2. COVID-19 symptoms were not predictive for testing positive in the follow-up test.The positive SARS-CoV-2 samples in the follow-up group represented 0.92% of all positive test results, highlighting the need for retesting and increased hygienic measures for borderline SARS-CoV-2 patients [NCT04636294].(c) 2021 Elsevier Inc. All rights reserved. | Keywords: | COVID-19;SARS-CoV-2;rRT-PCR;Borderline;Molecular diagnostics | Document URI: | http://hdl.handle.net/1942/36307 | ISSN: | 0732-8893 | e-ISSN: | 1879-0070 | DOI: | 10.1016/j.diagmicrobio.2021.115350 | ISI #: | 000647675900006 | Rights: | 2021 Elsevier Inc. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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Follow-up testing of borderline SARS-CoV-2 patients by rRT-PCR allows early diagnosis of COVID-19 _ Elsevier Enhanced Reader.pdf | Published version | 3.22 MB | Adobe PDF | View/Open |
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