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DC Field | Value | Language |
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dc.contributor.author | Abtahi, Shahab | - |
dc.contributor.author | Driessen, Johanna H. M. | - |
dc.contributor.author | Burden, Andrea M. | - |
dc.contributor.author | Souverein, Patrick C. | - |
dc.contributor.author | VAN DEN BERGH, Joop | - |
dc.contributor.author | van Staa, Tjeerd P. | - |
dc.contributor.author | Boonen, Annelies | - |
dc.contributor.author | de Vries, Frank | - |
dc.date.accessioned | 2021-12-27T15:02:06Z | - |
dc.date.available | 2021-12-27T15:02:06Z | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2021-12-19T22:17:11Z | - |
dc.identifier.citation | ANNALS OF THE RHEUMATIC DISEASES, 82 (4) (Art. N° e94) | - |
dc.identifier.issn | 0003-4967 | - |
dc.identifier.uri | http://hdl.handle.net/1942/36344 | - |
dc.description.abstract | Response to: 'Correspondence on 'Concomitant use of oral glucocorticoids and proton pump inhibitors and risk of osteoporotic fractures among patients with rheumatoid arthritis: a population-based cohort study'' by Zheng We thank Dr Zheng for his comments on our recently published article in the Annals of the Rheumatic Diseases entitled 'Concom-itant use of oral glucocorticoids and proton pump inhibitors and risk of osteoporotic fractures among patients with rheumatoid arthritis: a population-based cohort study'. 1 2 Our main goal in this study was to bring more clinical insight into the simultaneous use of these two common medications in patients with rheumatoid arthritis (RA), that is, oral glucocorticoids (GCs) and proton pump inhibitors (PPIs), using data from a large primary care database and pharmacoepidemiological methodologies. Our results showed that there was an interaction in the risk of osteoporotic (OP) fractures with concomitant use of oral GCs and PPIs in patients with RA. Based on the adjusted hazard ratios and according to the formula proposed by Rothman et al, 3 the relative excess risk due to interaction (RERI) was: 1.60-1.23 − 1.22 + 1 = 0.15. We now have also calculated the CIs and the statistical significance of this index using the method proposed by Hosmer and Lemeshow. 4 5 The lower and upper limits of the 95% CI of the RERI were −0.16 and 0.45, respectively, and the p value was 0.36. This means, although we observed a 15% more risk of OP fracture with concomitant use of oral GCs and PPIs in addition to the single use of each drug versus non-use of both, this additive interaction was not statistically significant. As we discussed in our paper, there is currently no proven biological mechanism for an action of PPIs on bone or falling, 6 while the effects of GCs on bone and the musculoskeletal system are quite established. Our secondary analyses (ie, lower fracture risk with long-term or higher daily doses of PPIs compared with short-term or lower daily doses) did not support the few proposed potential mechanisms, such as hypochlorhydria and calcium malabsorption, or an increased fall risk due to malab-sorption of magnesium or vitamin B 12. This is important to consider when interpreting a potential additive interaction between oral GCs and PPIs on fracture risk. Without this basic knowledge, it would be extremely difficult to confer any conclusions on a plausible synergistic action of these two drugs, since it would sound more as a methodological reasoning rather than a clinical explanation. | - |
dc.description.sponsorship | The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors. | - |
dc.language.iso | en | - |
dc.publisher | BMJ PUBLISHING GROUP | - |
dc.rights | Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ | - |
dc.subject.other | glucocorticoids | - |
dc.subject.other | rheumatoid arthritis | - |
dc.subject.other | osteoporosis | - |
dc.subject.other | epidemiology | - |
dc.title | Response to: ‘Correspondence on ‘Concomitant use of oral glucocorticoids and proton pump inhibitors and risk of osteoporotic fractures among patients with rheumatoid arthritis: a population-based cohort study’’ by Zheng | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 4 | - |
dc.identifier.volume | 82 | - |
local.format.pages | 2 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | de Vries, F (corresponding author), Maastricht Univ, Med Ctr, Dept Clin Pharm & Toxicol, Maastricht, Netherlands.; de Vries, F (corresponding author), Univ Utrecht, Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands.; de Vries, F (corresponding author), Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, Maastricht, Netherlands.; de Vries, F (corresponding author), Southampton Gen Hosp, MRC Epidemiol Lifecourse Unit, Southampton, Hants, England. | - |
dc.description.notes | f.devries@uu.nl | - |
local.publisher.place | BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Letter | - |
local.bibliographicCitation.artnr | e94 | - |
dc.identifier.doi | 10.1136/annrheumdis-2021-219856 | - |
dc.identifier.pmid | 33558257 | - |
dc.identifier.isi | 000726533900001 | - |
dc.contributor.orcid | Driessen, Johanna/0000-0002-4503-6408; Abtahi, | - |
dc.contributor.orcid | Shahab/0000-0003-0482-5563; de Vries, Frank/0000-0003-3837-8319 | - |
dc.identifier.eissn | 1468-2060 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Abtahi, Shahab; Driessen, Johanna H. M.; Burden, Andrea M.; de Vries, Frank] Maastricht Univ, Med Ctr, Dept Clin Pharm & Toxicol, Maastricht, Netherlands. | - |
local.description.affiliation | [Abtahi, Shahab; Driessen, Johanna H. M.; Souverein, Patrick C.; van Staa, Tjeerd P.; de Vries, Frank] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands. | - |
local.description.affiliation | [Abtahi, Shahab; Driessen, Johanna H. M.; de Vries, Frank] Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, Maastricht, Netherlands. | - |
local.description.affiliation | [Driessen, Johanna H. M.] Maastricht Univ, Med Ctr, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands. | - |
local.description.affiliation | [Burden, Andrea M.] Swiss Fed Inst Technol, Inst Pharmaceut Sci, Dept Chem & Appl Biosci, Zurich, Switzerland. | - |
local.description.affiliation | [van den Bergh, Joop P.; Boonen, Annelies] Maastricht Univ, Med Ctr, Dept Internal Med, Div Rheumatol, Maastricht, Netherlands. | - |
local.description.affiliation | [van den Bergh, Joop P.] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. | - |
local.description.affiliation | [van den Bergh, Joop P.] VieCuri Med Ctr, Dept Internal Med, Venlo, Netherlands. | - |
local.description.affiliation | [van Staa, Tjeerd P.] Univ Manchester, Fac Biol Med & Hlth, Sch Hlth Sci, Ctr Hlth Informat,Div Informat,Imaging & Data Sci, Manchester, Lancs, England. | - |
local.description.affiliation | [Boonen, Annelies] Maastricht Univ, Care & Publ Hlth Res Inst CAPHRI, Maastricht, Netherlands. | - |
local.description.affiliation | [de Vries, Frank] Southampton Gen Hosp, MRC Epidemiol Lifecourse Unit, Southampton, Hants, England. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Abtahi, Shahab; Driessen, Johanna H. M.; Burden, Andrea M.; Souverein, Patrick C.; VAN DEN BERGH, Joop; van Staa, Tjeerd P.; Boonen, Annelies & de Vries, Frank (2023) Response to: ‘Correspondence on ‘Concomitant use of oral glucocorticoids and proton pump inhibitors and risk of osteoporotic fractures among patients with rheumatoid arthritis: a population-based cohort study’’ by Zheng. In: ANNALS OF THE RHEUMATIC DISEASES, 82 (4) (Art. N° e94). | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.contributor | Abtahi, Shahab | - |
item.contributor | Driessen, Johanna H. M. | - |
item.contributor | Burden, Andrea M. | - |
item.contributor | Souverein, Patrick C. | - |
item.contributor | VAN DEN BERGH, Joop | - |
item.contributor | van Staa, Tjeerd P. | - |
item.contributor | Boonen, Annelies | - |
item.contributor | de Vries, Frank | - |
item.validation | ecoom 2022 | - |
crisitem.journal.issn | 0003-4967 | - |
crisitem.journal.eissn | 1468-2060 | - |
Appears in Collections: | Research publications |
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Response to_ ‘Correspondence on ‘Concomitant use of oral glucocorticoids and proton pump inhibitors and risk.pdf Restricted Access | Published version | 246.56 kB | Adobe PDF | View/Open Request a copy |
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