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http://hdl.handle.net/1942/36374
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DC Field | Value | Language |
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dc.contributor.author | Cortes-Guiral, Delia | - |
dc.contributor.author | Huebner, Martin | - |
dc.contributor.author | Alyami, Mohammad | - |
dc.contributor.author | Bhatt, Aditi | - |
dc.contributor.author | Ceelen , Wim | - |
dc.contributor.author | Glehen, Olivier | - |
dc.contributor.author | Lordick, Florian | - |
dc.contributor.author | Ramsay, Robert | - |
dc.contributor.author | Sgarbura, Olivia | - |
dc.contributor.author | VAN DER SPEETEN, Kurt | - |
dc.contributor.author | Turaga, Kiran K. | - |
dc.contributor.author | Chand, Manish | - |
dc.date.accessioned | 2022-01-05T09:17:46Z | - |
dc.date.available | 2022-01-05T09:17:46Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-12-23T12:27:55Z | - |
dc.identifier.citation | Nature reviews. Disease primers, 7 (1) (Art N° 91) | - |
dc.identifier.uri | http://hdl.handle.net/1942/36374 | - |
dc.description.abstract | Peritoneal surface malignancies comprise a heterogeneous group of primary tumours, including peritoneal mesothelioma, and peritoneal metastases of other tumours, including ovarian, gastric, colorectal, appendicular or pancreatic cancers. The pathophysiology of peritoneal malignancy is complex and not fully understood. The two main hypotheses are the transformation of mesothelial cells (peritoneal primary tumour) and shedding of cells from a primary tumour with implantation of cells in the peritoneal cavity (peritoneal metastasis). Diagnosis is challenging and often requires modern imaging and interventional techniques, including surgical exploration. In the past decade, new treatments and multimodal strategies helped to improve patient survival and quality of life and the premise that peritoneal malignancies are fatal diseases has been dismissed as management strategies, including complete cytoreductive surgery embedded in perioperative systemic chemotherapy, can provide cure in selected patients. Furthermore, intraperitoneal chemotherapy has become an important part of combination treatments. Improving locoregional treatment delivery to enhance penetration to tumour nodules and reduce systemic uptake is one of the most active research areas. The current main challenges involve not only offering the best treatment option and developing intraperitoneal therapies that are equivalent to current systemic therapies but also defining the optimal treatment sequence according to primary tumour, disease extent and patient preferences. New imaging modalities, less invasive surgery, nanomedicines and targeted therapies are the basis for a new era of intraperitoneal therapy and are beginning to show encouraging outcomes. Peritoneal surface malignancies have heterogeneous origins, including primary peritoneal tumours and metastases of other cancers, for example, digestive tract, reproductive tract, lung, breast and kidney tumours. This Primer reviews the epidemiology, mechanisms and diagnosis of these diseases, and discusses treatment options, patient quality of life and upcoming innovations. | - |
dc.description.sponsorship | The authors thank Jeanine for their contribution in Box 2. | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.rights | Springer Nature Limited 2021 | - |
dc.title | Primary and metastatic peritoneal surface malignancies | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 1 | - |
dc.identifier.volume | 7 | - |
local.format.pages | 23 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Cortes-Guiral, D (corresponding author), King Khaled Hosp, Surg Oncol & Gen Surg Dept, Najran, Saudi Arabia. | - |
dc.description.notes | delia.cortes.guiral@gmail.com | - |
local.publisher.place | HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 91 | - |
dc.identifier.doi | 10.1038/s41572-021-00326-6 | - |
dc.identifier.pmid | 34916522 | - |
dc.identifier.isi | 000730925600001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Cortes-Guiral, Delia; Alyami, Mohammad] King Khaled Hosp, Surg Oncol & Gen Surg Dept, Najran, Saudi Arabia. | - |
local.description.affiliation | [Huebner, Martin] Univ Lausanne UNIL, Lausanne Univ Hosp CHUV, Dept Visceral Surg, Lausanne, Switzerland. | - |
local.description.affiliation | [Bhatt, Aditi] Zydus Hosp, Dept Surg Oncol, Ahmadabad, Gujarat, India. | - |
local.description.affiliation | [Ceelen, Wim] Ghent Univ Hosp, Dept GI Surg, Ghent, Belgium. | - |
local.description.affiliation | [Glehen, Olivier] Ctr Hosp Univ Lyon Sud, Surg Dept, Pierre Benite, France. | - |
local.description.affiliation | [Lordick, Florian] Univ Leipzig, Univ Canc Ctr Leipzig, Med Ctr, Dept Oncol Gastroenterol Hepatol Pulmonol & Infec, Leipzig, Germany. | - |
local.description.affiliation | [Ramsay, Robert] Univ Melbourne, Peter MacCallum Canc Ctr, Melbourne, Vic, Australia. | - |
local.description.affiliation | [Ramsay, Robert] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia. | - |
local.description.affiliation | [Sgarbura, Olivia] Canc Inst Montpellier, Dept Surg Oncol, Montpellier, France. | - |
local.description.affiliation | [Van der Speeten, Kurt] Ziekenhuis Oost Limburg, Dept Surg Oncol, Genk, Belgium. | - |
local.description.affiliation | [Van der Speeten, Kurt] Univ Hasselt, Fac Med & Life Sci, BIOMED Res Inst, Hasselt, Belgium. | - |
local.description.affiliation | [Turaga, Kiran K.] Univ Chicago, Dept Surg, 5841 S Maryland Ave, Chicago, IL 60637 USA. | - |
local.description.affiliation | [Chand, Manish] UCL, Dept Surg, London, England. | - |
local.uhasselt.international | yes | - |
item.contributor | Cortes-Guiral, Delia | - |
item.contributor | Huebner, Martin | - |
item.contributor | Alyami, Mohammad | - |
item.contributor | Bhatt, Aditi | - |
item.contributor | Ceelen , Wim | - |
item.contributor | Glehen, Olivier | - |
item.contributor | Lordick, Florian | - |
item.contributor | Ramsay, Robert | - |
item.contributor | Sgarbura, Olivia | - |
item.contributor | VAN DER SPEETEN, Kurt | - |
item.contributor | Turaga, Kiran K. | - |
item.contributor | Chand, Manish | - |
item.fullcitation | Cortes-Guiral, Delia; Huebner, Martin; Alyami, Mohammad; Bhatt, Aditi; Ceelen , Wim; Glehen, Olivier; Lordick, Florian; Ramsay, Robert; Sgarbura, Olivia; VAN DER SPEETEN, Kurt; Turaga, Kiran K. & Chand, Manish (2021) Primary and metastatic peritoneal surface malignancies. In: Nature reviews. Disease primers, 7 (1) (Art N° 91). | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2022 | - |
crisitem.journal.issn | 2056-676X | - |
crisitem.journal.eissn | 2056-676X | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Primary and metastatic peritoneal surface malignancies.pdf | Published version | 2.88 MB | Adobe PDF | View/Open |
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