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http://hdl.handle.net/1942/36513
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DC Field | Value | Language |
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dc.contributor.author | VAN BROECKHOVEN, Jana | - |
dc.contributor.author | SOMMER, Daniela | - |
dc.contributor.author | DOOLEY, Dearbhaile | - |
dc.contributor.author | HENDRIX, Sven | - |
dc.contributor.author | FRANSSEN, Aimee | - |
dc.date.accessioned | 2022-01-17T15:34:27Z | - |
dc.date.available | 2022-01-17T15:34:27Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2022-01-17T06:15:08Z | - |
dc.identifier.citation | Brain (Print), 144 (10) , p. 2933 -2945 | - |
dc.identifier.uri | http://hdl.handle.net/1942/36513 | - |
dc.description.abstract | After spinal cord injury, macrophages can exert either beneficial or detrimental effects depending on their phenotype. Aside from their critical role in inflammatory responses, macrophages are also specialized in the recognition, engulfment, and degradation of pathogens, apoptotic cells, and tissue debris. They promote remyelination and axonal regeneration by removing inhibitory myelin components and cellular debris. However, excessive intracellular presence of lipids and dysregulated intracellular lipid homeostasis result in the formation of foamy macrophages. These develop a pro-inflammatory phenotype that may contribute to further neurological decline. Additionally, myelin-activated macrophages play a crucial role in axonal dieback and retraction. Here, we review the opposing functional consequences of phagocytosis by macrophages in spinal cord injury, including remyelination and regeneration versus demyelination, degeneration, and axonal dieback. Furthermore, we discuss how targeting the phagocytic ability of macrophages may have therapeutic potential for the treatment of spinal cord injury. | - |
dc.description.sponsorship | This work was supported by grants of the Fonds Wetenschappelijk OnderzoekâVlaanderen (FWO) to S.H. (G067715N, G091518N, G0C2120N). | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.rights | The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please email: journals.permissions@oup.com Free access | - |
dc.subject.other | CNS trauma | - |
dc.subject.other | phagocytosis | - |
dc.subject.other | foam cells | - |
dc.subject.other | axonal dieback | - |
dc.subject.other | technical challenges | - |
dc.title | Macrophage phagocytosis after spinal cord injury: when friends become foes | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 2945 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 2933 | - |
dc.identifier.volume | 144 | - |
local.format.pages | 13 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Hendrix, S (corresponding author), Hamburg Med Sch, Kaiserkai 1, D-20457 Hamburg, Germany. | - |
dc.description.notes | sven.hendrix@medicalschool-hamburg.de | - |
local.publisher.place | GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1093/brain/awab250 | - |
dc.identifier.pmid | 34244729 | - |
dc.identifier.isi | 000733375400010 | - |
dc.contributor.orcid | Van Broeckhoven, Jana/0000-0002-2884-1763; Hendrix, | - |
dc.contributor.orcid | Sven/0000-0003-2344-7369 | - |
dc.identifier.eissn | 1460-2156 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Van Broeckhoven, Jana; Sommer, Daniela; Hendrix, Sven; Franssen, Aimee J. P. M.] Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Diepenbeek, Belgium. | - |
local.description.affiliation | [Dooley, Dearbhaile] Univ Coll Dublin, Hlth Sci Ctr, Sch Med, Dublin 4, Ireland. | - |
local.description.affiliation | [Dooley, Dearbhaile] Univ Coll Dublin, UCD Conway Inst Biomol & Biomed Res, Dublin 4, Ireland. | - |
local.description.affiliation | [Hendrix, Sven] Med Sch Hamburg, Hamburg, Germany. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2022 | - |
item.contributor | VAN BROECKHOVEN, Jana | - |
item.contributor | SOMMER, Daniela | - |
item.contributor | DOOLEY, Dearbhaile | - |
item.contributor | HENDRIX, Sven | - |
item.contributor | FRANSSEN, Aimee | - |
item.accessRights | Restricted Access | - |
item.fullcitation | VAN BROECKHOVEN, Jana; SOMMER, Daniela; DOOLEY, Dearbhaile; HENDRIX, Sven & FRANSSEN, Aimee (2021) Macrophage phagocytosis after spinal cord injury: when friends become foes. In: Brain (Print), 144 (10) , p. 2933 -2945. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0006-8950 | - |
crisitem.journal.eissn | 1460-2156 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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OP-BRAI210253 2933..2945.pdf Restricted Access | Published version | 600.8 kB | Adobe PDF | View/Open Request a copy |
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