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http://hdl.handle.net/1942/36539
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DC Field | Value | Language |
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dc.contributor.author | Said, Fatema | - |
dc.contributor.author | ter Maaten, Jozine M. | - |
dc.contributor.author | MARTENS, Pieter | - |
dc.contributor.author | Vernooy, Kevin | - |
dc.contributor.author | Meine, Mathias | - |
dc.contributor.author | Allaart, Cornelis P. | - |
dc.contributor.author | Geelhoed, Bastiaan | - |
dc.contributor.author | Vos, Marc A. | - |
dc.contributor.author | Cramer , Maarten J. | - |
dc.contributor.author | van Gelder, Isabelle C. | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.contributor.author | Rienstra, Michiel | - |
dc.contributor.author | Maass, Alexander H. | - |
dc.date.accessioned | 2022-01-19T10:48:52Z | - |
dc.date.available | 2022-01-19T10:48:52Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2022-01-17T06:01:53Z | - |
dc.identifier.issn | - | |
dc.identifier.uri | http://hdl.handle.net/1942/36539 | - |
dc.description.abstract | Introduction: Cardiac resynchronization therapy (CRT) is an established therapy for patients with heart failure with reduced ejection fraction (HFrEF). Women appear to respond differently to CRT, yet it remains unclear whether this is inherent to the female sex itself, or due to other patient characteristics. In this study, we aimed to investigate sex differences in response to CRT. Methods: This is a post-hoc analysis of a prospective, multicenter study (MARC) in the Netherlands, studying HFrEF patients with an indication for CRT according to the guidelines (n = 240). Primary outcome measures are left ventricular ejection fraction (LVEF) and left ventricular end systolic volume (LVESV) at 6 months follow-up. Results were validated in an independent retrospective Belgian cohort (n = 818). Results: In the MARC cohort 39% were women, and in the Belgian cohort 32% were women. In the MARC cohort, 70% of the women were responders (defined as >15% decrease in LVESV) at 6 months, compared to 55% of men (p = 0.040) (79% vs. 67% in the Belgian cohort, p = 0.002). Women showed a greater decrease in LVESV %, LVESV indexed to body surface area (BSA) %, and increase in LVEF (all p < 0.05). In regression analysis, after adjustment for BSA and etiology, female sex was no longer associated with change in LVESV % and LVESV indexed to BSA % and LVEF % (p > 0.05 for all). Results were comparable in the Belgian cohort. Conclusions: Women showed a greater echocardiographic response to CRT at 6 months follow-up. However, after adjustment for BSA and ischemic etiology, no differences were found in LV-function measures or survival, suggesting that non-ischemic etiology is responsible for greater response rates in women treated with CRT. | - |
dc.description.sponsorship | The MARC study was performed within the framework of the CTMM, the Centre for Translational Molecular Medicine (www.ctmm.nl), project COHFAR (Congestive Heart Failure and Arrhythmias, grant 01C–203), and supported by the Dutch Heart Foundation. | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | - |
dc.subject.other | cardiac resynchronization therapy | - |
dc.subject.other | heart failure | - |
dc.subject.other | sex differences | - |
dc.title | Aetiology of Heart Failure, Rather than Sex, Determines Reverse LV Remodelling Response to CRT | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 23 | - |
dc.identifier.volume | 10 | - |
local.format.pages | 14 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Maass, AH (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9713 Groningen, Netherlands. | - |
dc.description.notes | kevin.vernooy@mumc.nl; cp.allaart@amsterdamumc.nl; | - |
dc.description.notes | M.A.Vos@umcutrecht.nl; wilfried.mullens@gmail.com | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 5513 | - |
dc.identifier.doi | 10.3390/jcm10235513 | - |
dc.identifier.isi | WOS:000735451800001 | - |
dc.contributor.orcid | Meine, Mathias/0000-0002-1102-2155; Rienstra, | - |
dc.contributor.orcid | Michiel/0000-0002-2581-070X | - |
dc.identifier.eissn | 2077-0383 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Said, Fatema; ter Maaten, Jozine M.; Geelhoed, Bastiaan; van Gelder, Isabelle C.; Rienstra, Michiel; Maass, Alexander H.] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9713 Groningen, Netherlands. | - |
local.description.affiliation | [ter Maaten, Jozine M.; Martens, Pieter; Mullens, Wilfried] Ziekenhuis Oost Limburg, Dept Cardiol, B-3600 Genk, Belgium. | - |
local.description.affiliation | [Martens, Pieter; Mullens, Wilfried] Hasselt Univ, Biomed Res Inst, Fac Med & Life Sci, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Vernooy, Kevin] Maastricht Univ, Med Ctr, Dept Cardiol, NL-6200 Maastricht, Netherlands. | - |
local.description.affiliation | [Meine, Mathias; Cramer, Maarten J.] Univ Med Ctr Utrecht, Dept Cardiol, NL-3584 Utrecht, Netherlands. | - |
local.description.affiliation | [Allaart, Cornelis P.] Vrije Univ Amsterdam, Med Ctr, Dept Cardiol, NL-1081 Amsterdam, Netherlands. | - |
local.description.affiliation | [Vos, Marc A.] Univ Utrecht, Dept Med Physiol, NL-3584 Utrecht, Netherlands. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Said, Fatema; ter Maaten, Jozine M.; MARTENS, Pieter; Vernooy, Kevin; Meine, Mathias; Allaart, Cornelis P.; Geelhoed, Bastiaan; Vos, Marc A.; Cramer , Maarten J.; van Gelder, Isabelle C.; MULLENS, Wilfried; Rienstra, Michiel & Maass, Alexander H. (2021) Aetiology of Heart Failure, Rather than Sex, Determines Reverse LV Remodelling Response to CRT. | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2023 | - |
item.contributor | Said, Fatema | - |
item.contributor | ter Maaten, Jozine M. | - |
item.contributor | MARTENS, Pieter | - |
item.contributor | Vernooy, Kevin | - |
item.contributor | Meine, Mathias | - |
item.contributor | Allaart, Cornelis P. | - |
item.contributor | Geelhoed, Bastiaan | - |
item.contributor | Vos, Marc A. | - |
item.contributor | Cramer , Maarten J. | - |
item.contributor | van Gelder, Isabelle C. | - |
item.contributor | MULLENS, Wilfried | - |
item.contributor | Rienstra, Michiel | - |
item.contributor | Maass, Alexander H. | - |
item.accessRights | Open Access | - |
crisitem.journal.eissn | 2077-0383 | - |
Appears in Collections: | Research publications |
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Aetiology of Heart Failure, Rather than Sex, Determines Reverse LV Remodelling Response to CRT.pdf | Published version | 579.97 kB | Adobe PDF | View/Open |
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