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Title: | Chest CT Diagnosis of COVID-19: Accuracy using CO-RADS and CT-Involvement Scoring | Authors: | Van Berkel, Brecht VANDEVENNE, Jan Coursier, Kristof Alberts, Vincent Van Offenwert, Jan Verduyckt, Jan Grieten, Martijn Siemons, Wim VERSWIJVEL, Geert |
Issue Date: | 2021 | Publisher: | UBIQUITY PRESS LTD | Source: | Journal of the Belgian Society of Radiology, 105 (1) , p. 17 (Art N° 17) | Abstract: | Objectives: Both Reporting and Data System (CO-RADS) and CT-involvement scores (CTIS) have been proposed for evaluation of COVID-19 on chest CT. The purpose of this single-center, retrospective study was to evaluate both scoring systems to diagnose COVID-19 infection in a high-prevalence area. Materials and Methods: Chest CT datasets (n = 200) and available reverse transcription polymerase chain reaction (RT-PCR) on nasopharyngeal swab were included. CT scans were assigned to four 'imaging groups' after scoring for both CO-RADS and CTIS. Diagnostic accuracy of chest CT was calculated respectively using RT-PCR and clinical diagnosis as gold standards: False-negatives and false-positives of chest CT regarding RT-PCR were studied in more depth using the medical files. Results: The 'imaging group' including CO-RADS 4/5 scores reached the highest diagnostic values for COVID-19 considering either the initial RT-PCR or the final clinical diagnosis as the standard of reference: accuracies of 172/200 (86%) to 181/200 (90.5%), sensitivities of 60/80 (88.2%) to 70/79 (88.6%), specificities of 112/132 (84.9%) to 111/121 (91.7%), negative predictive values (NPV) of 112/120 (93.3%) to 111/120 (92.5%), respectively. False-negative CTs regarding RT-PCR were mainly explained by imaging very early in the disease course (5 out of 8 cases) or COVID-19 infection with no/minor respiratory symptoms (3 out of 8 cases). Conclusion: Assessing chest CT using CO-RADS is a valuable diagnostic approach for COVID-19 infection in a high-prevalence area, with a higher accuracy than CTIS. | Notes: | Van Berkel, B (corresponding author), Ziekenhuis Oost Limburg, Dept Radiol, Schiepse Bos 6, B-3600 Genk, Belgium.; Van Berkel, B (corresponding author), Univ Hosp Leuven, Dept Radiol, Herestr 39, B-3000 Leuven, Belgium. brecht.vanberkel@zol.be |
Keywords: | COVID-19;COVID-19;CT;CT;RT-PCR;RT-PCR;CO-RADS;CO- RADS;Chest;Chest;Infection;Infection | Document URI: | http://hdl.handle.net/1942/36616 | ISSN: | 2514-8281 | e-ISSN: | 2514-8281 | DOI: | 10.5334/jbsr.2342 | ISI #: | 000744080300013 | Rights: | 2021 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/. Journal of the Belgian Society of Radiology is a peer-reviewed open access journal published by Ubiquity Press. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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2342-20870-1-PB.pdf | Published version | 1.52 MB | Adobe PDF | View/Open |
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