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http://hdl.handle.net/1942/36662
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DC Field | Value | Language |
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dc.contributor.author | KOC, Ozgur | - |
dc.contributor.author | Verbeek, J. | - |
dc.contributor.author | Koek, G. H. | - |
dc.contributor.author | BIELEN, Rob | - |
dc.contributor.author | BUSSCHOTS, Dana | - |
dc.contributor.author | Gamil, M. | - |
dc.contributor.author | ROBAEYS, Geert | - |
dc.contributor.author | Nevens , F. | - |
dc.date.accessioned | 2022-02-17T12:06:31Z | - |
dc.date.available | 2022-02-17T12:06:31Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-02-17T10:18:01Z | - |
dc.identifier.citation | ACTA GASTRO-ENTEROLOGICA BELGICA, 85 (1) , p. 56 -61 | - |
dc.identifier.issn | 1784-3227 | - |
dc.identifier.uri | http://hdl.handle.net/1942/36662 | - |
dc.description.abstract | Background and study aims: There is ongoing debate whether antiviral therapy should be initiated in hepatitis B e antigen (HBeAg)-negative patients with normal alanine aminotransferase (ALT) levels but high HBV DNA levels >2,000 IU/mL. Since the need for antiviral therapy might be different between Asian and Caucasian patients, we studied the long-term disease outcome in Caucasian patients living in Western Europe. Patients and methods: One hundred sixteen patients with high HBV DNA levels (>2,000 IU/mL) at diagnosis were included in the high viremia group, while those with HBV DNA <2,000 IU/ mL were used as controls (n = 327). All patients were Caucasian, HBeAg negative, had normal ALT levels and had no significant liver disease at diagnosis. Results: Median follow-up was 7 + 9.8 years in the high viremia group and this was 10 + 12.5 years in controls. The cumulative probability of a liver-related event over 10 years was 4.8% vs 0.0% in the control group (p=.008). In multivariable analysis, high viremia group was associated with the occurrence of a liver-related event (hazards ratio (HR) 95% confidence interval (CI): 1.20-11.98, p=.023). In this subgroup, older age at diagnosis (HR 95% CI: 1.011.16, p=.023) predicted a higher risk of liver-related event. In the high viremia group, liver-related mortality was 0.9% and none of the patients developed hepatocellular carcinoma. Conclusions: HBV DNA >2,000 IU/mL influences the long-term disease outcome in Caucasian HBeAg-negative patients living in Western Europe. Nevertheless, the risk of liver-related events is low. (Acta gastroenterol. belg., 2022, 85, 56-61). | - |
dc.description.sponsorship | foundation Limburg Sterk Merk; province of Limburg; Flemish | - |
dc.language.iso | en | - |
dc.publisher | UNIV CATHOLIQUE LOUVAIN-UCL | - |
dc.subject.other | hepatitis B | - |
dc.subject.other | Caucasian | - |
dc.subject.other | inactive carrier | - |
dc.subject.other | ALT | - |
dc.subject.other | HBV DNA | - |
dc.title | A long-term study of liver-related events in Caucasian hepatitis B patients with normal ALT values and high viremia | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 61 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 56 | - |
dc.identifier.volume | 85 | - |
local.format.pages | 6 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Koc, OM (corresponding author), Hasselt Univ, Fac Med & Life Sci, B-3500 Hasselt, Belgium. | - |
dc.description.notes | ozgur.koc@uhasselt.be | - |
local.publisher.place | CLIN UNIV SAINT LUC, AVE HIPPOCRATE 10, BRUSSELS, B-1200, BELGIUM | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.51821/85.1.9160 | - |
dc.identifier.isi | 000752361200001 | - |
dc.identifier.eissn | 1784-3227 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Koc, O. M.; Bielen, R.; Busschots, D.; Robaeys, G.] Hasselt Univ, Fac Hlth & Life Sci, Diepenbeek, Belgium. | - |
local.description.affiliation | [Koc, O. M.; Bielen, R.; Busschots, D.; Robaeys, G.] Ziekenhuis Oost Limburg, Dept Gastroenterol & Hepatol, Genk, Belgium. | - |
local.description.affiliation | [Koc, O. M.] Maastricht Univ, Sch NUTRIM, Dept Med Microbiol, Med Ctr, Maastricht, Netherlands. | - |
local.description.affiliation | [Verbeek, J.; Gamil, M.; Robaeys, G.; Nevens, F.] KU Leuven Univ Hosp, Dept Gastroenterol & Hepatol, Leuven, Belgium. | - |
local.description.affiliation | [Koek, G. H.] Maastricht Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Med Ctr, Maastricht, Netherlands. | - |
local.description.affiliation | [Koek, G. H.] Univ Hosp Aachen, Dept Surg, Aachen, Germany. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2023 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | KOC, Ozgur; Verbeek, J.; Koek, G. H.; BIELEN, Rob; BUSSCHOTS, Dana; Gamil, M.; ROBAEYS, Geert & Nevens , F. (2022) A long-term study of liver-related events in Caucasian hepatitis B patients with normal ALT values and high viremia. In: ACTA GASTRO-ENTEROLOGICA BELGICA, 85 (1) , p. 56 -61. | - |
item.accessRights | Open Access | - |
item.contributor | KOC, Ozgur | - |
item.contributor | Verbeek, J. | - |
item.contributor | Koek, G. H. | - |
item.contributor | BIELEN, Rob | - |
item.contributor | BUSSCHOTS, Dana | - |
item.contributor | Gamil, M. | - |
item.contributor | ROBAEYS, Geert | - |
item.contributor | Nevens , F. | - |
crisitem.journal.issn | 1784-3227 | - |
crisitem.journal.eissn | 1784-3227 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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10-Koc.pdf | Published version | 403 kB | Adobe PDF | View/Open |
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