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http://hdl.handle.net/1942/36668
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DC Field | Value | Language |
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dc.contributor.author | Maifeld, Andras | - |
dc.contributor.author | Wild, Johannes | - |
dc.contributor.author | Karlsen, Tine, V | - |
dc.contributor.author | Rakova, Natalia | - |
dc.contributor.author | Wistorf, Elisa | - |
dc.contributor.author | Linz, Peter | - |
dc.contributor.author | Jung , Rebecca | - |
dc.contributor.author | Birukov, Anna | - |
dc.contributor.author | Gimenez-Rivera, Vladimir-Andrey | - |
dc.contributor.author | Wilck, Nicola | - |
dc.contributor.author | Bartolomaeus, Theda | - |
dc.contributor.author | Dechend, Ralf | - |
dc.contributor.author | KLEINEWIETFELD, Markus | - |
dc.contributor.author | Forslund, Sofia K. | - |
dc.contributor.author | Krause, Andreas | - |
dc.contributor.author | Kokolakis, Georgios | - |
dc.contributor.author | Philipp, Sandra | - |
dc.contributor.author | Clausen, Bjoern E. | - |
dc.contributor.author | Brand , Anna | - |
dc.contributor.author | Waisman, Ari | - |
dc.contributor.author | Kurschus, Florian C. | - |
dc.contributor.author | Wegner, Joanna | - |
dc.contributor.author | Schultheis, Michael | - |
dc.contributor.author | Luft, Friedrich C. | - |
dc.contributor.author | Boschmann, Michael | - |
dc.contributor.author | Kelm, Marcus | - |
dc.contributor.author | Wiig, Helge | - |
dc.contributor.author | Kuehne, Titus | - |
dc.contributor.author | Muller, Dominik N. | - |
dc.contributor.author | Karbach, Susanne | - |
dc.contributor.author | Marko, Lajos | - |
dc.date.accessioned | 2022-02-17T13:19:25Z | - |
dc.date.available | 2022-02-17T13:19:25Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-02-17T10:17:27Z | - |
dc.identifier.citation | JOURNAL OF INVESTIGATIVE DERMATOLOGY, 142 (1) , p. 166 --+ | - |
dc.identifier.issn | 0022-202X | - |
dc.identifier.uri | http://hdl.handle.net/1942/36668 | - |
dc.description.abstract | Sodium can accumulate in the skin at concentrations exceeding serum levels. A high sodium environment can lead to pathogenic T helper 17 cell expansion. Psoriasis is a chronic inflammatory skin disease in which IL-17. producing T helper 17 cells play a crucial role. In an observational study, we measured skin sodium content in patients with psoriasis and in age-matched healthy controls by Sodium-23 magnetic resonance imaging. Patients with PASI > 5 showed significantly higher sodium and water content in the skin but not in other tissues than those with lower PASI or healthy controls. Skin sodium concentrations measured by Sodium-23 spectroscopy or by atomic absorption spectrometry in ashed-skin biopsies verified the findings with Sodium-23 magnetic resonance imaging. In vitro T helper 17 cell differentiation of naive CD4(+) cells from patients with psoriasis markedly induced IL-17A expression under increased sodium chloride concentrations. The imiquimod-induced psoriasis mouse model replicated the human findings. Extracellular tracer Chromium-51-EDTA measurements in imiquimod- and sham-treated skin showed similar extracellular volumes, rendering excessive water of intracellular origin. Chronic genetic IL-17A-driven psoriasis mouse models underlined the role of IL-17A in dermal sodium accumulation and inflammation. Our data describe skin sodium as a pathophysiological feature of psoriasis, which could open new avenues for its treatment. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.rights | 2021 The Authors. Published by Elsevier Inc. All rights reserved. | - |
dc.title | Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | + | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 166 | - |
dc.identifier.volume | 142 | - |
local.format.pages | 21 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Marko, L (corresponding author), Charite Univ Med Berlin, Expt & Clin Res Ctr, Lindenberger Weg 80, D-13125 Berlin, Germany.; Marko, L (corresponding author), Max Delbrack Ctr Mol Med, Lindenberger Weg 80, D-13125 Berlin, Germany. | - |
dc.description.notes | lajos.marko@charite.de | - |
local.publisher.place | STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.jid.2021.06.013 | - |
dc.identifier.isi | 000748758900025 | - |
dc.contributor.orcid | Wild, Johannes/0000-0002-1446-8101; Wilck, Nicola/0000-0003-3189-5364; | - |
dc.contributor.orcid | /0000-0001-8756-747X; Birukov, Anna/0000-0002-8306-3351; Karlsen, Tine | - |
dc.contributor.orcid | Veronica/0000-0002-1512-2479; Gimenez RIvera, Vladimir | - |
dc.contributor.orcid | Andrey/0000-0001-5055-208X | - |
dc.identifier.eissn | 1523-1747 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Maifeld, Andras; Rakova, Natalia; Wistorf, Elisa; Birukov, Anna; Wilck, Nicola; Bartolomaeus, Theda; Dechend, Ralf; Forslund, Sofia K.; Luft, Friedrich C.; Boschmann, Michael; Muller, Dominik N.; Marko, Lajos] Charite Univ Med Berlin, Expt & Clin Res Ctr, Lindenberger Weg 80, D-13125 Berlin, Germany. | - |
local.description.affiliation | [Maifeld, Andras; Rakova, Natalia; Wistorf, Elisa; Birukov, Anna; Wilck, Nicola; Bartolomaeus, Theda; Dechend, Ralf; Forslund, Sofia K.; Luft, Friedrich C.; Boschmann, Michael; Muller, Dominik N.; Marko, Lajos] Max Delbrack Ctr Mol Med, Lindenberger Weg 80, D-13125 Berlin, Germany. | - |
local.description.affiliation | [Maifeld, Andras; Birukov, Anna; Wilck, Nicola; Bartolomaeus, Theda; Dechend, Ralf; Forslund, Sofia K.; Muller, Dominik N.; Marko, Lajos] German Ctr Cardiovasc Res DZHK, Berlin, Germany. | - |
local.description.affiliation | [Maifeld, Andras; Wilck, Nicola; Dechend, Ralf; Forslund, Sofia K.; Boschmann, Michael; Kelm, Marcus; Muller, Dominik N.; Marko, Lajos] Charite Univ Med Berlin, Berlin Inst Hlth, Berlin, Germany. | - |
local.description.affiliation | [Maifeld, Andras; Bartolomaeus, Theda; Dechend, Ralf; Forslund, Sofia K.; Boschmann, Michael; Muller, Dominik N.; Marko, Lajos] Charite Univ Med Berlin, Berlin, Germany. | - |
local.description.affiliation | [Maifeld, Andras; Gimenez-Rivera, Vladimir-Andrey; Wilck, Nicola; Bartolomaeus, Theda; Dechend, Ralf; Forslund, Sofia K.; Kokolakis, Georgios; Philipp, Sandra; Boschmann, Michael; Kelm, Marcus; Kuehne, Titus; Muller, Dominik N.; Marko, Lajos] Free Univ Berlin, Berlin, Germany. | - |
local.description.affiliation | [Maifeld, Andras; Gimenez-Rivera, Vladimir-Andrey; Wilck, Nicola; Bartolomaeus, Theda; Dechend, Ralf; Forslund, Sofia K.; Kokolakis, Georgios; Philipp, Sandra; Boschmann, Michael; Kelm, Marcus; Kuehne, Titus; Muller, Dominik N.; Marko, Lajos] Humboldt Univ, Berlin, Germany. | - |
local.description.affiliation | [Wild, Johannes; Karbach, Susanne] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Cardiol Cardiol 1, Mainz, Germany. | - |
local.description.affiliation | [Wild, Johannes; Jung, Rebecca; Karbach, Susanne] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis CTH, Mainz, Germany. | - |
local.description.affiliation | [Karlsen, Tine, V; Wiig, Helge] Univ Bergen, Dept Biomed, Bergen, Norway. | - |
local.description.affiliation | [Linz, Peter] Friedrich Alexander Univ Erlangen Nurnberg, Inst Radiol, Erlangen, Germany. | - |
local.description.affiliation | [Linz, Peter; Clausen, Bjoern E.; Brand, Anna; Waisman, Ari] Friedrich Alexander Univ Erlangen Nurnberg, Dept Nephrol & Hypertens, Erlangen, Germany. | - |
local.description.affiliation | [Jung, Rebecca] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Mol Med, Mainz, Germany. | - |
local.description.affiliation | [Birukov, Anna] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany. | - |
local.description.affiliation | [Birukov, Anna] German Ctr Diabet Res DZD, Neuherberg, Germany. | - |
local.description.affiliation | [Gimenez-Rivera, Vladimir-Andrey] IntegraSkin GmbH iG, Tubingen, Germany. | - |
local.description.affiliation | [Wilck, Nicola] Charite Univ Med Berlin, Dept Nephrol & Internal Intens Care Med, Berlin, Germany. | - |
local.description.affiliation | [Dechend, Ralf] Helios Clin Berlin Buch, Berlin, Germany. | - |
local.description.affiliation | [Kleinewietfeld, Markus] VIB Ctr Inflammat Res IRC, VIB Lab Translat Immunomodulat, Hasselt Univ Campus, Diepenbeek, Hasselt, Belgium. | - |
local.description.affiliation | [Krause, Andreas] Immanuel Krankenhaus Berlin, Med Ctr Rheumatol & Clin Immunol, Berlin, Germany. | - |
local.description.affiliation | [Gimenez-Rivera, Vladimir-Andrey; Kokolakis, Georgios; Philipp, Sandra] Charite Univ Med Berlin, Dept Dermatol Venereol & Allergol, Berlin, Germany. | - |
local.description.affiliation | [Kurschus, Florian C.] Heidelberg Univ Hosp, Dept Dermatol, Heidelberg, Germany. | - |
local.description.affiliation | [Wegner, Joanna; Schultheis, Michael] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Dermatol, Mainz, Germany. | - |
local.description.affiliation | [Kelm, Marcus; Kuehne, Titus] Charite Univ Med Berlin, Inst Imaging Sci & Computat Modelling Cardiovasc, Berlin, Germany. | - |
local.description.affiliation | [Kelm, Marcus; Kuehne, Titus] German Heart Ctr Berlin DHZB, Dept Congenital Heart Dis, Berlin, Germany. | - |
local.description.affiliation | [Muller, Dominik N.] Helmholtz Assoc Berlin, Max Delbruck Ctr Mol Med, Berlin, Germany. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2023 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | Maifeld, Andras; Wild, Johannes; Karlsen, Tine, V; Rakova, Natalia; Wistorf, Elisa; Linz, Peter; Jung , Rebecca; Birukov, Anna; Gimenez-Rivera, Vladimir-Andrey; Wilck, Nicola; Bartolomaeus, Theda; Dechend, Ralf; KLEINEWIETFELD, Markus; Forslund, Sofia K.; Krause, Andreas; Kokolakis, Georgios; Philipp, Sandra; Clausen, Bjoern E.; Brand , Anna; Waisman, Ari; Kurschus, Florian C.; Wegner, Joanna; Schultheis, Michael; Luft, Friedrich C.; Boschmann, Michael; Kelm, Marcus; Wiig, Helge; Kuehne, Titus; Muller, Dominik N.; Karbach, Susanne & Marko, Lajos (2022) Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity. In: JOURNAL OF INVESTIGATIVE DERMATOLOGY, 142 (1) , p. 166 --+. | - |
item.accessRights | Restricted Access | - |
item.contributor | Maifeld, Andras | - |
item.contributor | Wild, Johannes | - |
item.contributor | Karlsen, Tine, V | - |
item.contributor | Rakova, Natalia | - |
item.contributor | Wistorf, Elisa | - |
item.contributor | Linz, Peter | - |
item.contributor | Jung , Rebecca | - |
item.contributor | Birukov, Anna | - |
item.contributor | Gimenez-Rivera, Vladimir-Andrey | - |
item.contributor | Wilck, Nicola | - |
item.contributor | Bartolomaeus, Theda | - |
item.contributor | Dechend, Ralf | - |
item.contributor | KLEINEWIETFELD, Markus | - |
item.contributor | Forslund, Sofia K. | - |
item.contributor | Krause, Andreas | - |
item.contributor | Kokolakis, Georgios | - |
item.contributor | Philipp, Sandra | - |
item.contributor | Clausen, Bjoern E. | - |
item.contributor | Brand , Anna | - |
item.contributor | Waisman, Ari | - |
item.contributor | Kurschus, Florian C. | - |
item.contributor | Wegner, Joanna | - |
item.contributor | Schultheis, Michael | - |
item.contributor | Luft, Friedrich C. | - |
item.contributor | Boschmann, Michael | - |
item.contributor | Kelm, Marcus | - |
item.contributor | Wiig, Helge | - |
item.contributor | Kuehne, Titus | - |
item.contributor | Muller, Dominik N. | - |
item.contributor | Karbach, Susanne | - |
item.contributor | Marko, Lajos | - |
crisitem.journal.issn | 0022-202X | - |
crisitem.journal.eissn | 1523-1747 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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1-s2.0-S0022202X21014238-main.pdf Restricted Access | Published version | 3.98 MB | Adobe PDF | View/Open Request a copy |
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