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http://hdl.handle.net/1942/36907
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DC Field | Value | Language |
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dc.contributor.author | Gu, Yifei | - |
dc.contributor.author | Wei, Lingfei | - |
dc.contributor.author | Zhang, Zheru | - |
dc.contributor.author | Van Dessel, Jeroen | - |
dc.contributor.author | DRIESEN, Ronald | - |
dc.contributor.author | LAMBRICHTS, Ivo | - |
dc.contributor.author | Jacobs, Reinhilde | - |
dc.contributor.author | Tian, Lei | - |
dc.contributor.author | SUN, Yi | - |
dc.contributor.author | Liu, Yuelian | - |
dc.contributor.author | POLITIS, Constantinus | - |
dc.date.accessioned | 2022-03-17T09:55:47Z | - |
dc.date.available | 2022-03-17T09:55:47Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-03-02T11:00:16Z | - |
dc.identifier.citation | MATERIALS & DESIGN, 215 (Art N° 110443) | - |
dc.identifier.issn | 0264-1275 | - |
dc.identifier.uri | http://hdl.handle.net/1942/36907 | - |
dc.description.abstract | The use of Ti6Al4V in bone engineering is limited, due to the biological inertia of the surface. In this study, a porous Ti6Al4V scaffold with mechanical properties similar to cancellous bone was designed and 3D-printed. Under physiological conditions, the scaffold was immersed firstly in a 5-fold-concentrated sim-ulated body fluid, then in a supersaturated CaP solution containing BMP-2, to form a bone-like porous micro/nano structured biomimetic coating on the surface. Scaffolds were implanted in the muscle pouches created in six beagle dogs and were retrieved four weeks later for histologic and histomorpho-metric analysis. Results showed that BMP-2 integrated biomimetic CaP coating induced ectopic bone for- mation, which was absent in other two groups. Soft tissue infiltrated the scaffold’s outside 1 mm layer, while the new-formed bone was evenly distributed in the longitudinal and horizontal directions withinv the rest of the scaffold based on BA/TA, BIC and BA measurements. In conclusion, the BMP-2 incorporated biomimetic CaP coating creates a micro/nano surface structure on the Ti6Al4V scaffold, which helps to increase biocompatibility. The integrated BMP-2 is capable of inducing ectopic bone formation in vivo | - |
dc.description.sponsorship | We acknowledged the contributions of all members of our research group to this article. This research was granted by National Natural Science Foundation of China(NSFC) No. 81670964, and Shandong Taishan Scholar Program to Dr. Yue-lian Liu. The authors appreciate Shanghai Rebone Biomaterials Co. for the supply of BMP-2 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | 2022 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | - |
dc.subject.other | Biomimetics | - |
dc.subject.other | 3D-printing | - |
dc.subject.other | Titanium alloy | - |
dc.subject.other | Bone morphogenetic protein 2 | - |
dc.subject.other | Calcium phosphate | - |
dc.subject.other | Bone substitutes | - |
dc.title | BMP-2 incorporated biomimetic CaP coating functionalized 3D printed Ti6Al4V scaffold induces ectopic bone formation in a dog model | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 215 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 110443 | - |
dc.identifier.doi | 10.1016/j.matdes.2022.110443 | - |
dc.identifier.isi | 000761249400001 | - |
dc.identifier.eissn | 1873-4197 | - |
local.provider.type | CrossRef | - |
local.dataset.doi | 10.1016/j.matdes.2022.110443 | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2023 | - |
item.contributor | Gu, Yifei | - |
item.contributor | Wei, Lingfei | - |
item.contributor | Zhang, Zheru | - |
item.contributor | Van Dessel, Jeroen | - |
item.contributor | DRIESEN, Ronald | - |
item.contributor | LAMBRICHTS, Ivo | - |
item.contributor | Jacobs, Reinhilde | - |
item.contributor | Tian, Lei | - |
item.contributor | SUN, Yi | - |
item.contributor | Liu, Yuelian | - |
item.contributor | POLITIS, Constantinus | - |
item.accessRights | Open Access | - |
item.fullcitation | Gu, Yifei; Wei, Lingfei; Zhang, Zheru; Van Dessel, Jeroen; DRIESEN, Ronald; LAMBRICHTS, Ivo; Jacobs, Reinhilde; Tian, Lei; SUN, Yi; Liu, Yuelian & POLITIS, Constantinus (2022) BMP-2 incorporated biomimetic CaP coating functionalized 3D printed Ti6Al4V scaffold induces ectopic bone formation in a dog model. In: MATERIALS & DESIGN, 215 (Art N° 110443). | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0264-1275 | - |
crisitem.journal.eissn | 1873-4197 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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1-s2.0-S0264127522000648-main.pdf | Published version | 3.95 MB | Adobe PDF | View/Open |
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