Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/36986
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHAIDAR, Mansour-
dc.contributor.authorLOIX, Melanie-
dc.contributor.authorVANHERLE, Sam-
dc.contributor.authorDIERCKX, Tess-
dc.contributor.authorVANGANSEWINKEL, Tim-
dc.contributor.authorGERVOIS, Pascal-
dc.contributor.authorWOLFS, Esther-
dc.contributor.authorLAMBRICHTS, Ivo-
dc.contributor.authorBOGIE, Jeroen-
dc.contributor.authorHENDRIKS, Jerome-
dc.date.accessioned2022-03-24T13:45:24Z-
dc.date.available2022-03-24T13:45:24Z-
dc.date.issued2022-
dc.date.submitted2022-03-14T11:57:48Z-
dc.identifier.citationAutophagy,-
dc.identifier.issn1554-8627-
dc.identifier.urihttp://hdl.handle.net/1942/36986-
dc.description.abstractFoamy macrophages containing abundant intracellular myelin remnants are an important pathological hallmark of multiple sclerosis. Reducing the intracellular lipid burden in foamy macrophages is considered a promising therapeutic strategy to induce a phagocyte phenotype that promotes central nervous system repair. Recent research from our group showed that sustained intracellular accumulation of myelin-derived lipids skews these phagocytes toward a disease-promoting and more inflammatory phenotype. Our data now demonstrate that disturbed lipophagy, a selective form of autophagy that helps with the degradation of lipid droplets, contributes to the induction of this phenotype. Stimulating autophagy using the natural disaccharide trehalose reduced the lipid load and inflammatory phenotype of myelin-laden macrophages. Importantly, trehalose was able to boost remyelination in the ex vivo brain slice model and the in vivo cuprizone-induced demyelination model. In summary, our results provide a molecular rationale for impaired metabolism of myelin-derived lipids in macrophages, and identify lipophagy induction as a promising treatment strategy to promote remyelination.-
dc.description.sponsorshipThe work has been supported by the Flemish Fund for ScientificResearch (FWO Vlaanderen; 1141920N, 12U7718N and 1502120N), theBelgian Charcot Foundation (Fondation Charcot 2020-0004), and thespecial research fund UHasselt (BOF)-
dc.language.isoen-
dc.publisherTAYLOR & FRANCIS INC-
dc.rights2022 Informa UK Limited, trading as Taylor & Francis Group-
dc.subject.otherLipid droplets-
dc.subject.otherlipophagy-
dc.subject.othermultiple sclerosis-
dc.subject.otherphagocyte-
dc.subject.otherremyelination-
dc.titleTargeting lipophagy in macrophages improves repair in multiple sclerosis-
dc.typeJournal Contribution-
dc.identifier.epage2710-
dc.identifier.issue11-
dc.identifier.spage2697-
dc.identifier.volume18-
local.format.pages14-
local.bibliographicCitation.jcatA1-
local.publisher.place530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1080/15548627.2022.2047343-
dc.identifier.pmid35282773-
dc.identifier.isi000768717200001-
dc.identifier.eissn1554-8635-
local.provider.typeCrossRef-
local.uhasselt.internationalno-
item.fulltextWith Fulltext-
item.contributorHAIDAR, Mansour-
item.contributorLOIX, Melanie-
item.contributorVANHERLE, Sam-
item.contributorDIERCKX, Tess-
item.contributorVANGANSEWINKEL, Tim-
item.contributorGERVOIS, Pascal-
item.contributorWOLFS, Esther-
item.contributorLAMBRICHTS, Ivo-
item.contributorBOGIE, Jeroen-
item.contributorHENDRIKS, Jerome-
item.fullcitationHAIDAR, Mansour; LOIX, Melanie; VANHERLE, Sam; DIERCKX, Tess; VANGANSEWINKEL, Tim; GERVOIS, Pascal; WOLFS, Esther; LAMBRICHTS, Ivo; BOGIE, Jeroen & HENDRIKS, Jerome (2022) Targeting lipophagy in macrophages improves repair in multiple sclerosis. In: Autophagy,.-
item.accessRightsOpen Access-
item.validationecoom 2023-
crisitem.journal.issn1554-8627-
crisitem.journal.eissn1554-8635-
Appears in Collections:Research publications
Files in This Item:
File Description SizeFormat 
Targeting lipophagy in macrophages improves repair in multiple sclerosis.pdf
  Restricted Access
Published version4.53 MBAdobe PDFView/Open    Request a copy
Haidar, Loix, et al., 2021. Revised manuscript_Final R3.pdfPeer-reviewed author version2.67 MBAdobe PDFView/Open
Show simple item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.