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http://hdl.handle.net/1942/36992
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DC Field | Value | Language |
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dc.contributor.author | HOOGLAND, Govert | - |
dc.contributor.author | RAIJMAKERS, Marjolein | - |
dc.contributor.author | CLYNEN, Elke | - |
dc.contributor.author | BRONE, Bert | - |
dc.contributor.author | RIGO, Jean-Michel | - |
dc.contributor.author | SWIJSEN, Ann | - |
dc.date.accessioned | 2022-03-24T14:52:33Z | - |
dc.date.available | 2022-03-24T14:52:33Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-03-10T13:56:47Z | - |
dc.identifier.citation | Brain and Behavior, (Art N° e2505) | - |
dc.identifier.uri | http://hdl.handle.net/1942/36992 | - |
dc.description.abstract | Prolonged febrile seizures (FS) are a risk factor for the development of hippocampal-associated temporal lobe epilepsy. The dentate gyrus is the major gateway to the hippocampal network and one of the sites in the brain where neurogenesis continues postnatally. Previously, we found that experimental FS increase the survival rate and structural integration of newborn dentate granule cells (DGCs). In addition, mature post-FS born DGCs express an altered receptor panel. Here, we aimed to study if these molecular and structural changes are accompanied by an altered cellular functioning. Experimental FS were induced by hyperthermia in 10-days-old Sprague-Dawley rats. Proliferating progenitor cells were labeled the next day by injecting green fluorescent protein expressing retroviral particles bilaterally in the dentate gyri. Eight weeks later, spontaneous excitatory and inhibitory postsynaptic events (sEPSCs and sIPSCs, respectively) were recorded from labeled DGCs using the whole-cell patch-clamp technique. Experimental FS resulted in a robust decrease of the inter event interval (p < .0001) and a small decrease of the amplitude of sEPSCs (p < .001). Collectively the spontaneous excitatory charge transfer increased (p < .01). Experimental FS also slightly increased the frequency of sIPSCs (p < .05), while the amplitude of these events decreased strongly (p < .0001). The net inhibitory charge transfer remained unchanged. Experimental, early-life FS have a long-term effect on post-FS born DGCs, as they display an increased spontaneous excitatory input when matured. It remains to be established if this presents a mechanism for FS-induced epileptogenesis. | - |
dc.description.sponsorship | 'Bijzonder Onderzoeksfonds' grant from Hasselt University We would like to thank H. van Praag for generously providing the plasmids that we used for the production of viral particles. Furthermore, we greatly appreciate the help of Petra Bex and Rosette Beenaerts for their assistance with this production. This research was financially supported by a ‘Bijzonder Onderzoeksfonds’ grant from Hasselt University. | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | - |
dc.subject.other | dentate granule cells | - |
dc.subject.other | epileptogenesis | - |
dc.subject.other | febrile seizures | - |
dc.subject.other | hyperexcitability | - |
dc.subject.other | neurogenesis | - |
dc.title | Experimental early‐life febrile seizures cause a sustained increase in excitatory neurotransmission in newborn dentate granule cells | - |
dc.type | Journal Contribution | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Rigo, JM (corresponding author), Martelarenlaan 42, B-3500 Hasselt, Belgium. | - |
dc.description.notes | jeanmichel.rigo@uhasselt.be | - |
local.publisher.place | 111 RIVER ST, HOBOKEN, NJ 07030 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | Early view | - |
local.bibliographicCitation.artnr | e2505 | - |
dc.identifier.doi | 10.1002/brb3.2505 | - |
dc.identifier.pmid | 35191203 | - |
dc.identifier.isi | WOS:000758686800001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Hoogland, Govert; Raijmakers, Marjolein] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Neurosurg, Med Ctr, Maastricht, Netherlands. | - |
local.description.affiliation | [Raijmakers, Marjolein; Clynen, Elke; Brone, Bert; Rigo, Jean-Michel; Swijsen, Ann] Hasselt Univ, Biomed Res Inst BIOMED, Neurophysiol Lab, Hasselt, Belgium. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2023 | - |
item.contributor | HOOGLAND, Govert | - |
item.contributor | RAIJMAKERS, Marjolein | - |
item.contributor | CLYNEN, Elke | - |
item.contributor | BRONE, Bert | - |
item.contributor | RIGO, Jean-Michel | - |
item.contributor | SWIJSEN, Ann | - |
item.accessRights | Open Access | - |
item.fullcitation | HOOGLAND, Govert; RAIJMAKERS, Marjolein; CLYNEN, Elke; BRONE, Bert; RIGO, Jean-Michel & SWIJSEN, Ann (2022) Experimental early‐life febrile seizures cause a sustained increase in excitatory neurotransmission in newborn dentate granule cells. In: Brain and Behavior, (Art N° e2505). | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 2162-3279 | - |
crisitem.journal.eissn | 2162-3279 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Experimental early‐life febrile seizures cause a sustained increase in excitatory neurotransmission in newborn dentate granule cells.pdf | Published version | 1.1 MB | Adobe PDF | View/Open |
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