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Title: | Determinants of carbon load in airway macrophages in pregnant women | Authors: | Miri, Mohammad Rezaei, Hossein Momtaz, Seyed Mojtaba Najafi, Moslem Lari Adli, Abolfazl Pajohanfar, Nasim Sadat Abroudi, Mina Bazghandi, Malihe Sadat Razavi, Zahra Alonso, Lucia Tonne, Cathryn Basagana, Xavier Nieuwenhuijsen, Mark J. Sunyer, Jordi NAWROT, Tim Dadvand, Payam |
Issue Date: | 2022 | Publisher: | ELSEVIER SCI LTD | Source: | ENVIRONMENTAL POLLUTION, 297 (Art N° 118765) | Abstract: | The airway macrophages carbon loading (AMCL) has been suggested to be a biomarker of the long-term exposure to air pollution; however, to date no study has characterized AMCL for the pregnancy period. Therefore, this study aimed to assess the determinants of AMCL during pregnancy in Iran, a middle-income country. This study was based on a sample of 234 pregnant women with term and normal vaginal delivery who were residing in Sabzevar, Iran (2019). We characterized 35 potential determinants of personal exposure to air pollution for each participant, including six personal, nine indoor, and 20 home-outdoor factors. We applied Deletion/Substitution/Addition algorithm to identify the most relevant determinants that could predict AMCL levels. The median (IQR) of AMCL level was 0.12 (0.30) mu m(2) with a successful sputum induction in 82.9% (194) of participants. Ambient residential PM2.5 levels were positively associated with higher AMCL levels. On the other hand, increased residential distance to the traffic lights, squares and ring-roads, the duration of opening window per day, and opening window during cooking were inversely associated with AMCL levels. Our findings provide novel insights on the different personal, indoor, and outdoor determinants of personal exposure to air pollution during pregnancy in a middle-income country. | Notes: | Dadvand, P (corresponding author), Barcelona Inst Global Hlth ISGlobal, Doctor Aiguader 88, Barcelona 08005, Spain. Payam.dadvand@isglobal.org |
Keywords: | Air pollution;Pregnancy;Biomarker;Phagocytosis;Lung | Document URI: | http://hdl.handle.net/1942/37097 | ISSN: | 0269-7491 | e-ISSN: | 1873-6424 | DOI: | 10.1016/j.envpol.2021.118765 | ISI #: | WOS:000760273500004 | Rights: | 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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Determinants of carbon load in airway macrophages in pregnant women.pdf | Published version | 5.75 MB | Adobe PDF | View/Open |
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