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Title: | Scar formation from the perspective of complexity science: a new look at the biological system as a whole | Authors: | Korkmaz, H. Ibrahim Niessen, Frank B. Pijpe, Anouk Sheraton, Vivek M. VERMOLEN, Fred Krijnen, Paul Aj Niessen, Hans Wm Sloot, Peter Ma Middelkoop, Esther Gibbs, Susan van Zuijlen, Paul Pm |
Issue Date: | 2022 | Publisher: | MA HEALTHCARE LTD | Source: | Journal of Wound Care, 31 (2) , p. 178 -184 | Abstract: | A burn wound is a complex systemic disease at multiple levels. Current knowledge of scar formation after burn injury has come from traditional biological and clinical studies. These are normally focused on just a small part of the entire process, which has limited our ability to sufficiently understand the underlying mechanisms and to predict systems behaviour. Scar formation after burn injury is a result of a complex biological system-wound healing. It is a part of a larger whole. In this self-organising system, many components form networks of interactions with each other. These networks of interactions are typically non-linear and change their states dynamically, responding to the environment and showing emergent long-term behaviour. How molecular and cellular data relate to clinical phenomena, especially regarding effective therapies of burn wounds to achieve minimal scarring, is difficult to unravel and comprehend. Complexity science can help bridge this gap by integrating small parts into a larger whole, such that relevant biological mechanisms and data are combined in a computational model to better understand the complexity of the entire biological system. A better understanding of the complex biological system of post-burn scar formation could bring research and treatment regimens to the next level. The aim of this review/position paper is to create more awareness of complexity in scar formation after burn injury by describing the basic principles of complexity science and its potential for burn care professionals. | Notes: | Korkmaz, HI (corresponding author), Amsterdam UMC, Dept Plast Reconstruct & Hand Surg, Locat VUmc, Amsterdam Movement Sci AMS Inst, Amsterdam, Netherlands.; Korkmaz, HI (corresponding author), Amsterdam UMC, Locat VUmc, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands.; Korkmaz, HI (corresponding author), Red Cross Hosp, Burn Ctr, Beverwijk, Netherlands.; Korkmaz, HI (corresponding author), Red Cross Hosp, Dept Plast & Reconstruct Surg, Beverwijk, Netherlands.; Korkmaz, HI (corresponding author), Assoc Dutch Burn Ctr ADBC, Beverwijk, Netherlands. h.korkmaz@amsterdamumc.nl |
Keywords: | burn;burn care;complexity;complexity science;scar formation;systems biology;woundwound care;wound healing;wounds | Document URI: | http://hdl.handle.net/1942/37103 | ISSN: | 0969-0700 | e-ISSN: | 2062-2916 | DOI: | 10.12968/jowc.2022.31.2.178 | ISI #: | WOS:000758652400011 | Rights: | 2021 MA Healthcare Ltd | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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JOWC_2022_31_02_000_Korkmaz 210122 ls BC 2.pdf Restricted Access | Published version | 125.49 kB | Adobe PDF | View/Open Request a copy |
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