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http://hdl.handle.net/1942/37117
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DC Field | Value | Language |
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dc.contributor.author | NGUYEN, Minh Hanh | - |
dc.contributor.author | Fornes, R. | - |
dc.contributor.author | KAMAU, Njeri | - |
dc.contributor.author | Danielsson, H. | - |
dc.contributor.author | Callens, S. | - |
dc.contributor.author | Fransson, E. | - |
dc.contributor.author | Engstrand, L. | - |
dc.contributor.author | BRUYNDONCKX, Robin | - |
dc.contributor.author | Brusselaers, N. | - |
dc.date.accessioned | 2022-03-31T09:21:37Z | - |
dc.date.available | 2022-03-31T09:21:37Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-03-25T11:48:32Z | - |
dc.identifier.citation | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, | - |
dc.identifier.uri | http://hdl.handle.net/1942/37117 | - |
dc.description.abstract | Objectives To assess the impact of gestational antibiotics on the risk of preterm birth, since a healthy maternal microbiome may be protective. Methods Population-based cohort study including all first pregnancies in Sweden (2006-16). The association between gestational and recent pre-conception systemic antibiotics and preterm birth was assessed by multivariable logistic regression presented as ORs and 95% CIs, adjusted for comorbidities (hypo- and hyperthyroidism, hypertension, or diabetes mellitus pre-gestation), trimester, antibiotic class and treatment duration. Results Compared with non-users, antibiotic exposure was associated with increased risks of preterm birth in mothers with comorbidities (OR = 1.32, 95% CI 1.18-1.48) and without (OR = 1.09, 95% CI 1.06-1.13). Pre-conception use showed no association, while risk was increased for first and second trimester use and decreased for third trimester use. The increased risks were seen for the following antibiotic groups in mothers without and with comorbidities, respectively: macrolides, lincosamides and streptogramins (OR = 1.63, 95% CI 1.45-1.83; OR = 2.48, 95% CI 1.72-3.56); quinolones (OR = 1.60, 95% CI 1.32-1.94; OR = 2.11, 95% CI 1.12-4.03); non-penicillin beta-lactams (OR = 1.15, 95% CI 1.07-1.24; OR = 1.39, 95% CI 1.07-1.83); other antibacterials (OR = 1.09, 95% CI 1.03-1.14; 1.38, 95% CI 1.16-1.63); and penicillins (OR = 1.04, 95% CI 1.01-1.08; 1.23, 95% CI 1.09-1.40). Antibiotic indications were not available, which could also affect preterm birth. Conclusions Antibiotic use during pregnancy was associated with an increased risk of preterm birth, especially in mothers with chronic diseases. | - |
dc.description.sponsorship | This study was supported by internal funding. R.B. was funded as a postdoctoral researcher by the Research Foundation—Flanders (FWO: 2019-2021, 12I6319N). R.F. was funded by Becas Chile, HKH Kronprinsessan Lovisas förening för barnasjukvård och Stiftelsen Axel Tielmans minnesfond Lovisas. | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.rights | The Author(s) 2022. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | - |
dc.title | Antibiotic use during pregnancy and the risk of preterm birth: a population-based Swedish cohort study | - |
dc.type | Journal Contribution | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Brusselaers, N (corresponding author), Karolinska Inst, Ctr Translat Microbiome Res, Dept Microbiol Tumour & Cell Biol, Stockholm, Sweden.; Brusselaers, N (corresponding author), Antwerp Univ, Global Hlth Inst, Antwerp, Belgium. | - |
dc.description.notes | nele.brusselaers@ki.se | - |
local.publisher.place | GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | Early view | - |
dc.identifier.doi | 10.1093/jac/dkac053 | - |
dc.identifier.isi | WOS:000762654600001 | - |
dc.contributor.orcid | Brusselaers, Nele/0000-0003-0137-447X | - |
local.provider.type | wosris | - |
local.description.affiliation | [Nguyen, M. H.; Kamau, N.; Bruyndonckx, R.] Hasselt Univ, Data Sci Inst, I BioStat, Hasselt, Belgium. | - |
local.description.affiliation | [Nguyen, M. H.; Fornes, R.; Kamau, N.; Danielsson, H.; Fransson, E.; Engstrand, L.; Brusselaers, N.] Karolinska Inst, Ctr Translat Microbiome Res, Dept Microbiol Tumour & Cell Biol, Stockholm, Sweden. | - |
local.description.affiliation | [Danielsson, H.] Sachs Childrens & Youth Hosp, Sodersjukhuset, Stockholm, Sweden. | - |
local.description.affiliation | [Callens, S.] Univ Ghent, Dept Internal Med & Paediat, Ghent, Belgium. | - |
local.description.affiliation | [Bruyndonckx, R.] Univ Antwerp, Lab Med Microbiol Vaccine & Infect Dis Inst VAXIN, Antwerp, Belgium. | - |
local.description.affiliation | [Brusselaers, N.] Antwerp Univ, Global Hlth Inst, Antwerp, Belgium. | - |
local.description.affiliation | [Brusselaers, N.] Univ Ghent, Dept Head & Skin, Ghent, Belgium. | - |
local.uhasselt.international | yes | - |
item.fullcitation | NGUYEN, Minh Hanh; Fornes, R.; KAMAU, Njeri; Danielsson, H.; Callens, S.; Fransson, E.; Engstrand, L.; BRUYNDONCKX, Robin & Brusselaers, N. (2022) Antibiotic use during pregnancy and the risk of preterm birth: a population-based Swedish cohort study. In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,. | - |
item.validation | ecoom 2023 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.contributor | NGUYEN, Minh Hanh | - |
item.contributor | Fornes, R. | - |
item.contributor | KAMAU, Njeri | - |
item.contributor | Danielsson, H. | - |
item.contributor | Callens, S. | - |
item.contributor | Fransson, E. | - |
item.contributor | Engstrand, L. | - |
item.contributor | BRUYNDONCKX, Robin | - |
item.contributor | Brusselaers, N. | - |
crisitem.journal.issn | 0305-7453 | - |
crisitem.journal.eissn | 1460-2091 | - |
Appears in Collections: | Research publications |
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Antibiotic use during pregnancy and the risk of preterm birth_ a population-based Swedish cohort study.pdf | Published version | 265.28 kB | Adobe PDF | View/Open |
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