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Title: | Age-dependent non-linear neuroplastic effects of cathodal tDCS in the elderly population: a titration study | Authors: | GHASEMIAN SHIRVAN, Ensiyeh Mosayebi-Samani, Mohsen Farnad, Leila Kuo, Min-Fang MEESEN, Raf Nitsche, Michael |
Issue Date: | 2022 | Publisher: | Source: | Brain Stimulation, 15 (2) , p. 296 -305 | Abstract: | Background: Neuromodulatory effects of transcranial direct current stimulation (tDCS) in older humans have shown heterogeneous results, possibly due to sub-optimal stimulation protocols associated with limited knowledge about optimized stimulation parameters in this age group. We systematically explored the association between the stimulation dosage of cathodal tDCS and induced after-effects on motor cortex excitability in the elderly. Method: Thirty-nine healthy volunteers in two age groups, namely Pre-Elderly (50e65 years) and Elderly (66e80 years), participated in the study. Ten sessions of cathodal tDCS, with a combination of four intensities (1, 2, 3 mA and sham) and three durations (15, 20, 30 min) were conducted over the M1 in each participant. Cortical excitability changes were monitored with TMS-induced motor evoked potentials (MEPs) for up to 2 h after stimulation. Results: Motor cortex excitability was reduced by cathodal stimulation intensities of 1 and 3 mA in both age groups, in accordance with results observed in the younger age groups of previous studies. For the 2 mA stimulation condition, an age-dependent conversion of plasticity into a stimulation duration-dependent excitability enhancement was observed in the Pre-Elderly group, whereas in the Elderly group, LTD-like plasticity was preserved, or abolished, depending on stimulation duration. Conclusion: The LTD-like plasticity effects induced by cathodal tDCS originally described in young adults are also observable in older humans, but non-linearities of the resulting plasticity were partially preserved only in the Pre-Elderly, but not the Elderly group. These results aid in understanding age-dependent plasticity dynamics in humans, and to define more efficient tDCS protocols in the aging brain. | Keywords: | tDCS;TMS;Motor cortex;Aging;Non-linear plasticity | Document URI: | http://hdl.handle.net/1942/37149 | ISSN: | 1935-861X | e-ISSN: | 1876-4754 | DOI: | 10.1016/j.brs.2022.01.011 | ISI #: | 000792490000004 | Rights: | 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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PIIS1935861X22000122.pdf | Published version | 1.37 MB | Adobe PDF | View/Open |
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