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http://hdl.handle.net/1942/3719
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DC Field | Value | Language |
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dc.contributor.author | CHIN, Y | - |
dc.contributor.author | JANSSENS, Jaak | - |
dc.contributor.author | BLEUS, Josianne | - |
dc.contributor.author | ZHANG, JINGWU | - |
dc.contributor.author | RAUS, Jef | - |
dc.date.accessioned | 2007-11-29T12:50:21Z | - |
dc.date.available | 2007-11-29T12:50:21Z | - |
dc.date.issued | 1994 | - |
dc.identifier.citation | ONCOLOGY REPORTS, 1(3). p. 577-583 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | http://hdl.handle.net/1942/3719 | - |
dc.description.abstract | 51 T cell lines/clones were established from tumor-infiltrating lymphocytes of nine breast tumors by limiting dilution. All the lines/clones were exclusively CD3+ and expressed either CD4 (57%) or CD8 (26%) phenotype. In addition, 17% of the lines/clones displayed a dual expression of CD4+CD8+ antigens. No CD3-CD16+ NK clones were obtained. A vast majority of the T cell lines and clones (84%) exhibited cytolytic activity in a lectin-dependent assay which allows the detection of cytolytic T cells of any antigen specificity. 17% of the lines/clones lysed two allogeneic breast tumor cell lines, MCF-7 and HBL-100. 11% of the cells showed NK-like cytolysis by lysing an NK-sensitive cell line K562. Of the 17 lines tested against autologous tumor cells, only two exhibited cytolytic activity via T cell receptor and CD3 molecule in an MHC-restricted manner. Southern blot analysis of T cell receptor of 39 lines/clones revealed a limited heterogeneity of TCR-B chain gene rearrangements, which suggests oligoclonal expansion of T cells infiltrating into the tumor. | - |
dc.language.iso | en | - |
dc.publisher | INT JOURNAL ONCOLOGY | - |
dc.subject.other | TUMOR INFILTRATING LYMPHOCYTES; T CELL CLONING; T CELL RECEPTOR; GENE REARRANGEMENTS | - |
dc.title | CELLULAR AND MOLECULAR ANALYSIS OF TUMOR-INFILTRATING T-LYMPHOCYTES FROM HUMAN BREAST-CANCER AT CLONAL LEVEL | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 583 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 577 | - |
dc.identifier.volume | 1 | - |
local.format.pages | 7 | - |
dc.description.notes | LIMBURGS UNIV CENTRUM,B-3610 DIEPENBEEK,BELGIUM.CHIN, Y, DR L WILLEMS INST,DEPT CANC RES,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.isi | A1994PW22400022 | - |
item.fulltext | No Fulltext | - |
item.fullcitation | CHIN, Y; JANSSENS, Jaak; BLEUS, Josianne; ZHANG, JINGWU & RAUS, Jef (1994) CELLULAR AND MOLECULAR ANALYSIS OF TUMOR-INFILTRATING T-LYMPHOCYTES FROM HUMAN BREAST-CANCER AT CLONAL LEVEL. In: ONCOLOGY REPORTS, 1(3). p. 577-583. | - |
item.contributor | CHIN, Y | - |
item.contributor | JANSSENS, Jaak | - |
item.contributor | BLEUS, Josianne | - |
item.contributor | ZHANG, JINGWU | - |
item.contributor | RAUS, Jef | - |
item.accessRights | Closed Access | - |
Appears in Collections: | Research publications |
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