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http://hdl.handle.net/1942/37206
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DC Field | Value | Language |
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dc.contributor.author | MESOTTEN, Dieter | - |
dc.contributor.author | Meijs, Daniek A. M. | - |
dc.contributor.author | van Bussel, Bas C. T. | - |
dc.contributor.author | STESSEL, Bjorn | - |
dc.contributor.author | Mehagnoul-Schipper, Jannet | - |
dc.contributor.author | Hana, Anisa | - |
dc.contributor.author | Scheeren, Clarissa I. E. | - |
dc.contributor.author | Strauch, Ulrich | - |
dc.contributor.author | van de Poll, Marcel C. G. | - |
dc.contributor.author | Ghossein-Doha, Chahinda | - |
dc.contributor.author | Buhre, Wolfgang F. F. A. | - |
dc.contributor.author | Bickenbach, Johannes | - |
dc.contributor.author | VANDER LAENEN, Margot | - |
dc.contributor.author | Marx, Gernot | - |
dc.contributor.author | van der Horst, Iwan C. C. | - |
dc.date.accessioned | 2022-04-14T13:54:02Z | - |
dc.date.available | 2022-04-14T13:54:02Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-04-07T11:42:42Z | - |
dc.identifier.citation | CRITICAL CARE MEDICINE, 50 (4) , p. 595 -606 | - |
dc.identifier.uri | http://hdl.handle.net/1942/37206 | - |
dc.description.abstract | OBJECTIVES: To investigate healthcare system-driven variation in general characteristics, interventions, and outcomes in coronavirus disease 2019 (COVID-19) patients admitted to the ICU within one Western European region across three countries. DESIGN: Multicenter observational cohort study. SETTING: Seven ICUs in the Euregio Meuse-Rhine, one region across Belgium, The Netherlands, and Germany. PATIENTS: Consecutive COVID-19 patients supported in the ICU during the first pandemic wave. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Baseline demographic and clinical characteristics, laboratory values, and outcome data were retrieved after ethical approval and data-sharing agreements. Descriptive statistics were performed to investigate country-related practice variation. From March 2, 2020, to August 12, 2020, 551 patients were admitted. Mean age was 65.4 +/- 11.2 years, and 29% were female. At admission, Acute Physiology and Chronic Health Evaluation II scores were 15.0 +/- 5.5, 16.8 +/- 5.5, and 15.8 +/- 5.3 (p = 0.002), and Sequential Organ Failure Assessment scores were 4.4 +/- 2.7, 7.4 +/- 2.2, and 7.7 +/- 3.2 (p < 0.001) in the Belgian, Dutch, and German parts of Euregio, respectively. The ICU mortality rate was 22%, 42%, and 44%, respectively (p < 0.001). Large differences were observed in the frequency of organ support, antimicrobial/inflammatory therapy application, and ICU capacity. Mixed-multivariable logistic regression analyses showed that differences in ICU mortality were independent of age, sex, disease severity, comorbidities, support strategies, therapies, and complications. CONCLUSIONS: COVID-19 patients admitted to ICUs within one region, the Euregio Meuse-Rhine, differed significantly in general characteristics, applied interventions, and outcomes despite presumed genetic and socioeconomic background, admission diagnosis, access to international literature, and data collection are similar. Variances in healthcare systems' organization, particularly ICU capacity and admission criteria, combined with a rapidly spreading pandemic might be important drivers for the observed differences. Heterogeneity between patient groups but also healthcare systems should be presumed to interfere with outcomes in coronavirus disease 2019. | - |
dc.description.sponsorship | This paper is part of the CoDaP project funded by Interreg Euregio Meuse-Rhine (EMR) grant number 187. This grant was acquired by Prof. Mesotten, Dr. van Bussel, Dr. Stessel, Prof. Marx, and Prof. van der Horst. Dr. Strauch was also supported by Interreg EMR Pandemric grant number 177. | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.rights | Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons AttributionNon Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited | - |
dc.subject.other | coronavirus disease 2019; critical care; delivery of healthcare; | - |
dc.subject.other | healthcare economics and organizations; intensive care units; severe | - |
dc.subject.other | acute respiratory syndrome coronavirus 2 | - |
dc.title | Differences and Similarities Among Coronavirus Disease 2019 Patients Treated in Seven ICUs in Three Countries Within One Region | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 606 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 595 | - |
dc.identifier.volume | 50 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Meijs, DAM (corresponding author), Maastricht Univ, Dept Intens Care, Med Ctr, Maastricht, Netherlands.; Meijs, DAM (corresponding author), Laurentius Ziekenhuis, Dept Intens Care, Roermond, Netherlands. | - |
dc.description.notes | daniek.meijs@mumc.nl | - |
local.publisher.place | TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1097/CCM.0000000000005314 | - |
dc.identifier.isi | WOS:000771070100027 | - |
dc.contributor.orcid | Buhre, Wolfgang/0000-0002-8296-9426 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Mesotten, Dieter; Vander Laenen, Margot] Ziekenhuis Oost Limburg, Dept Intens Care, Genk, Belgium. | - |
local.description.affiliation | [Mesotten, Dieter; Stessel, Bjorn] UHasselt, Fac Med & Life Sci, Diepenbeek, Belgium. | - |
local.description.affiliation | [Meijs, Daniek A. M.; van Bussel, Bas C. T.; Strauch, Ulrich; van de Poll, Marcel C. G.; Ghossein-Doha, Chahinda; van der Horst, Iwan C. C.] Maastricht Univ, Dept Intens Care, Med Ctr, Maastricht, Netherlands. | - |
local.description.affiliation | [Meijs, Daniek A. M.; Hana, Anisa] Laurentius Ziekenhuis, Dept Intens Care, Roermond, Netherlands. | - |
local.description.affiliation | [van Bussel, Bas C. T.] Maastricht Univ, Care & Publ Hlth Res Inst, Maastricht, Netherlands. | - |
local.description.affiliation | [Stessel, Bjorn] Jessa Hosp, Dept Intens Care, Hasselt, Belgium. | - |
local.description.affiliation | [Mehagnoul-Schipper, Jannet] VieCuri Med Ctr, Dept Intens Care, Venlo, Netherlands. | - |
local.description.affiliation | [Scheeren, Clarissa I. E.] Zuyderland Med Ctr, Dept Intens Care, Heerlen Sittard, Netherlands. | - |
local.description.affiliation | [van de Poll, Marcel C. G.] Maastricht Univ, Dept Surg, Med Ctr, Maastricht, Netherlands. | - |
local.description.affiliation | [van de Poll, Marcel C. G.] Maastricht Univ, Sch Nutr & Translat Res Metab, Maastricht, Netherlands. | - |
local.description.affiliation | [Ghossein-Doha, Chahinda; van der Horst, Iwan C. C.] Cardiovasc Res Inst Maastricht, Maastricht, Netherlands. | - |
local.description.affiliation | [Buhre, Wolfgang F. F. A.] Maastricht Univ, Div Acute & Emergency Med, Med Ctr, Maastricht, Netherlands. | - |
local.description.affiliation | [Bickenbach, Johannes; Marx, Gernot] Rhein Westfalische Hsch Aachen, Dept Intens Care, Univ Hosp, Aachen, Germany. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2023 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | MESOTTEN, Dieter; Meijs, Daniek A. M.; van Bussel, Bas C. T.; STESSEL, Bjorn; Mehagnoul-Schipper, Jannet; Hana, Anisa; Scheeren, Clarissa I. E.; Strauch, Ulrich; van de Poll, Marcel C. G.; Ghossein-Doha, Chahinda; Buhre, Wolfgang F. F. A.; Bickenbach, Johannes; VANDER LAENEN, Margot; Marx, Gernot & van der Horst, Iwan C. C. (2022) Differences and Similarities Among Coronavirus Disease 2019 Patients Treated in Seven ICUs in Three Countries Within One Region. In: CRITICAL CARE MEDICINE, 50 (4) , p. 595 -606. | - |
item.contributor | MESOTTEN, Dieter | - |
item.contributor | Meijs, Daniek A. M. | - |
item.contributor | van Bussel, Bas C. T. | - |
item.contributor | STESSEL, Bjorn | - |
item.contributor | Mehagnoul-Schipper, Jannet | - |
item.contributor | Hana, Anisa | - |
item.contributor | Scheeren, Clarissa I. E. | - |
item.contributor | Strauch, Ulrich | - |
item.contributor | van de Poll, Marcel C. G. | - |
item.contributor | Ghossein-Doha, Chahinda | - |
item.contributor | Buhre, Wolfgang F. F. A. | - |
item.contributor | Bickenbach, Johannes | - |
item.contributor | VANDER LAENEN, Margot | - |
item.contributor | Marx, Gernot | - |
item.contributor | van der Horst, Iwan C. C. | - |
crisitem.journal.issn | 0090-3493 | - |
crisitem.journal.eissn | 1530-0293 | - |
Appears in Collections: | Research publications |
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Differences_and_Similarities_Among_COVID_19.7.pdf | Published version | 1.19 MB | Adobe PDF | View/Open |
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