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Title: | High-Salt Diet Induces Depletion of Lactic Acid-Producing Bacteria in Murine Gut | Authors: | HAMAD, Ibrahim CARDILLI, Alessio FERNANDES CORTE-REAL, Beatriz DYCZKO, Aleksandra VANGRONSVELD, Jaco KLEINEWIETFELD, Markus |
Issue Date: | 2022 | Publisher: | MDPI | Source: | NUTRIENTS, 14 (6) , (Art N° 1171) | Abstract: | Dietary habits are amongst the main factors that influence the gut microbiome. Accumulating evidence points to the impact of a high-salt diet (HSD) on the composition and function of the intestinal microbiota, immune system and disease. In the present study, we thus investigated the effects of different NaCl content in the food (0.03%/sodium deficient, 0.5%/control, 4% and 10% NaCl) on the gut microbiome composition in mice. The bacterial composition was profiled using the 16S ribosomal RNA (rRNA) gene amplicon sequencing. Our results revealed that HSD led to distinct gut microbiome compositions compared to sodium-deficient or control diets. We also observed significant reduction in relative abundances of bacteria associated with immuno-competent short-chain fatty acid (SCFA) production (Bifidobacterium, Faecalibaculum, Blautia and Lactobacillus) in HSD-fed mice along with significant enrichment of Clostridia, Alistipes and Akkermansia depending on the sodium content in food. Furthermore, the predictive functional profiling of microbial communities indicated that the gut microbiota found in each category presents differences in metabolic pathways related to carbohydrate, lipid and amino acid metabolism. The presented data show that HSD cause disturbances in the ecological balance of the gastrointestinal microflora primarily through depletion of lactic acid-producing bacteria in a dose-dependent manner. These findings may have important implications for salt-sensitive inflammatory diseases. | Notes: | Kleinewietfeld, M (corresponding author), Hasselt Univ, Ctr Inflammat Res IRC, VIB Lab Translat Immunomodulat, B-3590 Diepenbeek, Belgium.; Kleinewietfeld, M (corresponding author), Hasselt Univ, Biomed Res Inst BIOMED, Dept Immunol & Infect, B-3590 Diepenbeek, Belgium. ibrahim.hamad@uhasselt.be; alessio.cardilli@uhasselt.be; beatriz.cortereal@uhasselt.vib.be; aleksandra.dyczko@uhasselt.be; jaco.vangronsveld@uhasselt.be; markus.kleinewietfeld@uhasselt.vib.be |
Keywords: | gut microbiome; sodium chloride (dietary); dysbiosis; bacterial;metabolites; inflammation | Document URI: | http://hdl.handle.net/1942/37229 | e-ISSN: | 2072-6643 | DOI: | 10.3390/nu14061171 | ISI #: | WOS:000774369700001 | Rights: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/) | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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nutrients-14-01171-v2.pdf | Published version | 2.2 MB | Adobe PDF | View/Open |
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