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http://hdl.handle.net/1942/37306
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DC Field | Value | Language |
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dc.contributor.author | DAUW, Jeroen | - |
dc.contributor.author | MARTENS, Pieter | - |
dc.contributor.author | NIJST, Petra | - |
dc.contributor.author | MEEKERS, Evelyne | - |
dc.contributor.author | DEFERM, Sebastien | - |
dc.contributor.author | GRUWEZ, Henri | - |
dc.contributor.author | Rivero-Ayerza, Maximo | - |
dc.contributor.author | Van Herendael, Hugo | - |
dc.contributor.author | PISON, Laurent | - |
dc.contributor.author | NUYENS, Dieter | - |
dc.contributor.author | DUPONT, Matthias | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.date.accessioned | 2022-05-13T15:50:57Z | - |
dc.date.available | 2022-05-13T15:50:57Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-05-10T14:30:46Z | - |
dc.identifier.citation | EUROPACE, MAR 2022 | - |
dc.identifier.uri | http://hdl.handle.net/1942/37306 | - |
dc.description.abstract | Aims The aim of this study is to evaluate whether the MADIT-ICD benefit score can predict who benefits most from the addition of implantable cardioverter-defibrillator (ICD) to cardiac resynchronization therapy (CRT) in real-world patients with heart failure with reduced ejection fraction (HFrEF) and to compare this with selection according to a multidisciplinary expert centre approach. Methods and results Consecutive HFrEF patients who received a CRT for a guideline indication at a tertiary care hospital (Ziekenhuis Oost-Limburg, Genk, Belgium) between October 2008 and September 2016, were retrospectively evaluated. The MADIT-ICD benefit groups (low, intermediate, and high) were compared with the current multidisciplinary expert centre approach. Endpoints were (i) sustained ventricular tachycardia (VT) or ventricular fibrillation (VF) and (ii) non-arrhythmic mortality. Of the 475 included patients, 165 (34.7%) were in the lowest, 220 (46.3%) in the intermediate, and 90 (19.0%) in the highest benefit group. After a median follow-up of 34 months, VT/VF occurred in 3 (1.8%) patients in the lowest, 9 (4.1%) in the intermediate, and 13 (14.4%) in the highest benefit group (P < 0.001). Vice versa, non-arrhythmic death occurred in 32 (19.4%) in the lowest, 32 (14.6%) in the intermediate, and 3 (3.3%) in the highest benefit group (P = 0.002). The predictive power for ICD benefit was comparable between expert multidisciplinary judgement and the MADIT-ICD benefit score: Uno's C-statistic 0.69 vs. 0.69 (P = 0.936) for VT/VF and 0.62 vs. 0.60 (P = 0.790) for non-arrhythmic mortality. Conclusion The MADIT-ICD benefit score can identify who benefits most from CRT-D and is comparable with multidisciplinary judgement in a CRT expert centre. | - |
dc.description.sponsorship | J.D., E.M., H.G., S.D., and W.M. are researchers for the Limburg Clinical Research Center (LCRC) UHasselt-ZOL-Jessa and supported by the foundation Limburg Sterk Merk (LSM), Province of Limburg, Flemish Government, Hasselt University, Ziekenhuis Oost-Limburg, and Jessa Hospital. H.G. was also supported as predoctoral strategic basic research fellow by the Fund for Scientific Research Flanders (FWO1S83221N). | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject.other | Heart failure; Implantable cardioverter-defibrillator; Cardiac | - |
dc.subject.other | resynchronization therapy; Patient selection; MADIT-ICD benefit score | - |
dc.title | The MADIT-ICD benefit score helps to select implantable cardioverter-defibrillator candidates in cardiac resynchronization therapy | - |
dc.type | Journal Contribution | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Mullens, W (corresponding author), Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. | - |
dc.description.notes | wilfried.mullens@zol.be | - |
local.publisher.place | GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | Early view | - |
dc.identifier.doi | 10.1093/europace/euac039 | - |
dc.identifier.isi | WOS:000784737700001 | - |
dc.contributor.orcid | Gruwez, Henri/0000-0002-9169-265X | - |
local.provider.type | wosris | - |
local.description.affiliation | [Dauw, Jeroen; Martens, Pieter; Nijst, Petra; Meekers, Evelyne; Deferm, Sebastien; Gruwez, Henri; Rivero-Ayerza, Maximo; Van Herendael, Hugo; Pison, Laurent; Nuyens, Dieter; Dupont, Matthias; Mullens, Wilfried] Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. | - |
local.description.affiliation | [Dauw, Jeroen; Meekers, Evelyne; Deferm, Sebastien; Gruwez, Henri] UHasselt, LCRC, Doctoral Sch Med & Life Sci, Diepenbeek, Belgium. | - |
local.description.affiliation | [Mullens, Wilfried] UHasselt, Biomed Res Inst, LCRC, Fac Med & Life Sci, Diepenbeek, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | No Fulltext | - |
item.contributor | DAUW, Jeroen | - |
item.contributor | MARTENS, Pieter | - |
item.contributor | NIJST, Petra | - |
item.contributor | MEEKERS, Evelyne | - |
item.contributor | DEFERM, Sebastien | - |
item.contributor | GRUWEZ, Henri | - |
item.contributor | Rivero-Ayerza, Maximo | - |
item.contributor | Van Herendael, Hugo | - |
item.contributor | PISON, Laurent | - |
item.contributor | NUYENS, Dieter | - |
item.contributor | DUPONT, Matthias | - |
item.contributor | MULLENS, Wilfried | - |
item.accessRights | Closed Access | - |
item.fullcitation | DAUW, Jeroen; MARTENS, Pieter; NIJST, Petra; MEEKERS, Evelyne; DEFERM, Sebastien; GRUWEZ, Henri; Rivero-Ayerza, Maximo; Van Herendael, Hugo; PISON, Laurent; NUYENS, Dieter; DUPONT, Matthias & MULLENS, Wilfried (2022) The MADIT-ICD benefit score helps to select implantable cardioverter-defibrillator candidates in cardiac resynchronization therapy. In: EUROPACE, MAR 2022. | - |
item.validation | ecoom 2023 | - |
crisitem.journal.issn | 1099-5129 | - |
crisitem.journal.eissn | 1532-2092 | - |
Appears in Collections: | Research publications |
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