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dc.contributor.authorDAUW, Jeroen-
dc.contributor.authorMartens, Pieter-
dc.contributor.authorNIJST, Petra-
dc.contributor.authorMEEKERS, Evelyne-
dc.contributor.authorDEFERM, Sebastien-
dc.contributor.authorGRUWEZ, Henri-
dc.contributor.authorRivero-Ayerza, Maximo-
dc.contributor.authorVan Herendael, Hugo-
dc.contributor.authorPISON, Laurent-
dc.contributor.authorNUYENS, Dieter-
dc.contributor.authorDUPONT, Matthias-
dc.contributor.authorMULLENS, Wilfried-
dc.identifier.citationEUROPACE, MAR 2022-
dc.description.abstractAims The aim of this study is to evaluate whether the MADIT-ICD benefit score can predict who benefits most from the addition of implantable cardioverter-defibrillator (ICD) to cardiac resynchronization therapy (CRT) in real-world patients with heart failure with reduced ejection fraction (HFrEF) and to compare this with selection according to a multidisciplinary expert centre approach. Methods and results Consecutive HFrEF patients who received a CRT for a guideline indication at a tertiary care hospital (Ziekenhuis Oost-Limburg, Genk, Belgium) between October 2008 and September 2016, were retrospectively evaluated. The MADIT-ICD benefit groups (low, intermediate, and high) were compared with the current multidisciplinary expert centre approach. Endpoints were (i) sustained ventricular tachycardia (VT) or ventricular fibrillation (VF) and (ii) non-arrhythmic mortality. Of the 475 included patients, 165 (34.7%) were in the lowest, 220 (46.3%) in the intermediate, and 90 (19.0%) in the highest benefit group. After a median follow-up of 34 months, VT/VF occurred in 3 (1.8%) patients in the lowest, 9 (4.1%) in the intermediate, and 13 (14.4%) in the highest benefit group (P < 0.001). Vice versa, non-arrhythmic death occurred in 32 (19.4%) in the lowest, 32 (14.6%) in the intermediate, and 3 (3.3%) in the highest benefit group (P = 0.002). The predictive power for ICD benefit was comparable between expert multidisciplinary judgement and the MADIT-ICD benefit score: Uno's C-statistic 0.69 vs. 0.69 (P = 0.936) for VT/VF and 0.62 vs. 0.60 (P = 0.790) for non-arrhythmic mortality. Conclusion The MADIT-ICD benefit score can identify who benefits most from CRT-D and is comparable with multidisciplinary judgement in a CRT expert centre.-
dc.description.sponsorshipJ.D., E.M., H.G., S.D., and W.M. are researchers for the Limburg Clinical Research Center (LCRC) UHasselt-ZOL-Jessa and supported by the foundation Limburg Sterk Merk (LSM), Province of Limburg, Flemish Government, Hasselt University, Ziekenhuis Oost-Limburg, and Jessa Hospital. H.G. was also supported as predoctoral strategic basic research fellow by the Fund for Scientific Research Flanders (FWO1S83221N).-
dc.publisherOXFORD UNIV PRESS-
dc.subject.otherHeart failure; Implantable cardioverter-defibrillator; Cardiac-
dc.subject.otherresynchronization therapy; Patient selection; MADIT-ICD benefit score-
dc.titleThe MADIT-ICD benefit score helps to select implantable cardioverter-defibrillator candidates in cardiac resynchronization therapy-
dc.typeJournal Contribution-
dc.description.notesMullens, W (corresponding author), Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium.-
local.bibliographicCitation.statusEarly view-
dc.contributor.orcidGruwez, Henri/0000-0002-9169-265X-
local.description.affiliation[Dauw, Jeroen; Martens, Pieter; Nijst, Petra; Meekers, Evelyne; Deferm, Sebastien; Gruwez, Henri; Rivero-Ayerza, Maximo; Van Herendael, Hugo; Pison, Laurent; Nuyens, Dieter; Dupont, Matthias; Mullens, Wilfried] Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium.-
local.description.affiliation[Dauw, Jeroen; Meekers, Evelyne; Deferm, Sebastien; Gruwez, Henri] UHasselt, LCRC, Doctoral Sch Med & Life Sci, Diepenbeek, Belgium.-
local.description.affiliation[Mullens, Wilfried] UHasselt, Biomed Res Inst, LCRC, Fac Med & Life Sci, Diepenbeek, Belgium.-
item.fulltextNo Fulltext-
item.accessRightsClosed Access-
item.fullcitationDAUW, Jeroen; Martens, Pieter; NIJST, Petra; MEEKERS, Evelyne; DEFERM, Sebastien; GRUWEZ, Henri; Rivero-Ayerza, Maximo; Van Herendael, Hugo; PISON, Laurent; NUYENS, Dieter; DUPONT, Matthias & MULLENS, Wilfried (2022) The MADIT-ICD benefit score helps to select implantable cardioverter-defibrillator candidates in cardiac resynchronization therapy. In: EUROPACE, MAR 2022.-
item.contributorDAUW, Jeroen-
item.contributorMULLENS, Wilfried-
item.contributorDEFERM, Sebastien-
item.contributorMartens, Pieter-
item.contributorDUPONT, Matthias-
item.contributorNUYENS, Dieter-
item.contributorGRUWEZ, Henri-
item.contributorRivero-Ayerza, Maximo-
item.contributorPISON, Laurent-
item.contributorMEEKERS, Evelyne-
item.contributorVan Herendael, Hugo-
item.contributorNIJST, Petra-
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