Perinatal outcome after icsi compared to a low-cost simplified ivf system in a selected population: A prospective cohort study

Abstract

Results: Initially 484 studies were idientified from various online databases and after proper and thorough review only 10 were of significance to this study. The outcomes of local recurrence for both breast-conserving surgery patients and patients that underwent mastectomy were fed into the software as dichotomous values and were analyzed as odd ratios (OR). The analysis was performed using the Mantel-Haenszel method and by utilizing a fixed effect analysis model. Conclusions: Extraction of the tumor and radiotherapy tend to be the preferable methods of treating phyllodes tumors of the breast. Standard common practices for other more common malignancies definitely helped in the treatment and survival rates of patients suffering from a phyllodes tumor of the breast. 307 Pregnancy rate after icsi compared to a low-cost simplified ivf system in a selected population: A prospective cohort study Aim of the study: By using split ICSI/simplified IVF culture system (SCS) cycles in a selected patient cohort, we examined if regular IVF methodology could be significantly simplified and still yields results comparable with ICSI. Methods: This analysis is part of a non-inferiority prospective study comparing ICSI and SCS for gamete fertilization and embryo culture in a selected group of patients. For women, selection criteria included being under 43 years of age and to have at least 6 eggs at retrieval. Only men with a post-wash motile sperm count of >1 million were included. The primary outcome measure was ongoing pregnancy rate (OPR, > 12 weeks). Secondary outcome measures included implantation-, fertilization rate and number of cryopreserved embryos. Half of the eggs were treated with SCS and ICSI. If an odd number or more than 20 eggs were retrieved, the additional eggs were treated with ICSI. Results: From January 2016 until December 2019, 564 split SCS/ICSI cycles were performed. In 20.4 % of cases no transfer was performed, mostly because of the risk for OHSS. The OPR was 32.7 % for SCS and 40.0 % for ICSI (p=0.11). Implantation rate (IR) per embryo was 31.5 % for SCS and 37.7 % for ICSI (p=0.16). Fertilization rate (FR) was 61.5 % and 50.4 % for SCS and ICSI respectively (p<0.0001). Embryos were useful for cryopreservation in 50.0 % and 51.6 % of cases after SCS and ICSI (p=0.73). A total of 797 and 527 embryos were cryopreserved after ICSI and SCS respectively accounting for 20.7 % and 17.1 % per oocyte retrieved (p=0.0002). The miscarriage rate was 12 % and 6.9 % for SCS and ICSI (p=0.21). Conclusion: We found no difference in ongoing pregnancy rate, implantation rate and miscarriage rate between SCS and ICSI in this selected patient cohort.