Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/37346
Title: | End-tidal CO2 levels in rest, during and after respiratory challenges: a comparison between patients with medically unexplained physical symptoms, panic disorder patients and healthy controls | Authors: | RAMAKERS, Indra VAN DEN HOUTE, Maaike VAN DEN BERGH, Omer VAN OUDENHOVE, Lukas BOGAERTS, Katleen |
Issue Date: | 2021 | Source: | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 39 (3) , p. S212 | Abstract: | Background. Although a dysregulated autonomic stress physiology is hypothesized to play a crucial role in the etiology and perpetuation of Medically Unexplained Physical Symptoms (MUPS), the respiratory system tends to be overlooked in current available literature. Objectives. The aim of our study was 1) to examine end-tidal CO2 concentration (PetCO2) in patients experiencing MUPS in daily life, diagnosed with overstrain, burnout, and functional somatic syndromes (FSS), compared to patients with panic disorder (PD) and healthy controls (HC) and 2) to explore the triangular relationship between psychological variables (maladaptive perfectionism, experiential avoidance, and exposure to traumatic experiences), the stress response system, and MUPS. Methods. Three groups of MUPS patients (overstrain [n=35], burnout [n=44] and fibromyalgia/chronic fatigue syndrome (CFS) [n=36]), PD patients (n=36) and HC (n=30) filled out trait questionnaires and went through a baseline measurement of PetCO2 and two respiratory challenges with recovery whilst PetCO2 was continuously monitored by a capnograph. Results. Our data showed respiratory abnormalities in MUPS and PD patients compared to HC, suggesting a transdiagnostic mechanism for both stress and anxiety related disorders. This dysfunction was found to be partially mediated by maladaptive perfectionism, experiential avoidance, and exposure to traumatic experiences. Furthermore, we found preliminary evidence for a chronicity and severity-based MUPS-continuum underlying 1) overstrain, 2) burnout, and 3) fibromyalgia/CFS in ascending order, characterized by an increasing depletion of the stress-response system. Conclusion. Our results are indicative for dysfunctional activity of the autonomic nervous system, including the respiratory system, to be an underlying working mechanism of MUPS. | Document URI: | http://hdl.handle.net/1942/37346 | Link to publication/dataset: | https://limo.libis.be/primo-explore/fulldisplay?docid=LIRIAS3486792&context=L&vid=Lirias&search_scope=Lirias&tab=default_tab&fromSitemap=1 | ISSN: | 0392-856X | e-ISSN: | 1593-098X | DOI: | https://doi.org/10.55563/clinexprheumatol/b9m6ao | Category: | M | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
xx.pdf Restricted Access | Published version | 2.77 MB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.