Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/37430
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | De Craemer, Ann-Sophie | - |
dc.contributor.author | Renson, Thomas | - |
dc.contributor.author | Deroo, Liselotte | - |
dc.contributor.author | VAN PRAET, Liesbet | - |
dc.contributor.author | Cypers, Heleen | - |
dc.contributor.author | Varkas, Gaelle | - |
dc.contributor.author | JOOS, Rik | - |
dc.contributor.author | Devinck, Mieke | - |
dc.contributor.author | Gyselbrecht, Lieve | - |
dc.contributor.author | Peene, Isabelle | - |
dc.contributor.author | THEVISSEN, Kristof | - |
dc.contributor.author | Costantino, Felicie | - |
dc.contributor.author | D'Agostino, Maria-Antonietta | - |
dc.contributor.author | LENAERTS, Jan | - |
dc.contributor.author | Carron, Philippe | - |
dc.contributor.author | VAN DEN BOSCH, Filip | - |
dc.contributor.author | Elewaut, Dirk | - |
dc.date.accessioned | 2022-06-02T12:33:25Z | - |
dc.date.available | 2022-06-02T12:33:25Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-05-17T08:30:45Z | - |
dc.identifier.citation | RHEUMATOLOGY, 61 (8) , p. 3279-3288 | - |
dc.identifier.uri | http://hdl.handle.net/1942/37430 | - |
dc.description.abstract | Objectives To delineate the impact of peripheral musculoskeletal manifestations on stratification of disease phenotype and outcome in new-onset spondyloarthritis (SpA), using a prospective observational nationwide inception cohort, the BelGian Inflammatory Arthritis and spoNdylitis cohorT (Be-Giant). Methods Newly diagnosed adult SpA patients, fulfilling the Assessment of SpondyloArthritis International Society (ASAS) criteria for axial or peripheral SpA, were included in Be-Giant and prospectively followed every six months. Peripheral involvement (defined as arthritis, enthesitis and/or dactylitis) was determined in relation to clinically similar patient subsets at baseline and disease activity patterns during two-year follow-up, identified through K-means cluster analysis and latent class growth analysis. Results From November 2010 to March 2020, 367 patients were enrolled in Be-Giant, of whom 162 (44%) had peripheral manifestations. Two patient clusters [A, axial predominant (n = 248) and B, peripheral predominant (n = 119)] were identified at diagnosis. Longitudinal analysis (n = 115) revealed two trajectories of disease activity in each cluster: one with persistently high disease activity over time ('High'), the other rapidly evolving to low disease activity ('Low'). In cluster A patients, peripheral manifestations predisposed to the 'High' trajectory [odds ratio (OR) = 2.0, 95% CI: 1.3, 3.1, P = 0.001], despite more rapid initiation of biologics compared with patients without peripheral manifestations (hazard ratio (HR) = 2.1, 95% CI: 1.0, 4.4, P = 0.04 - Cox proportional-hazards model). Conclusion Peripheral musculoskeletal manifestations are major determinants of phenotypical diversity in new-onset SpA. Intriguingly, stratification of axial SpA according to concomitant peripheral involvement identified an endotype with an unfavorable outcome despite more prompt therapeutic intensification with biologics. These observations justify an endotype-tailored approach beyond current ASAS/EULAR management recommendations. | - |
dc.description.sponsorship | We thank the study participants, rheumatology and research nurses, and clinicians who have contributed to this study. A-S.DC., F.C., M-A.DA., F.VdB. and D.E. conceptualized and designed the study. A-S.DC., T.R., L.D., L.VP., H.C., G.V., R.J., M.D., L.G., I.P., K.T., J.L., P.C. and F.VdB. collected original clinical data. A-S.DC. performed statistical analysis and prepared the manuscript. A-S.DC., T.R., L.D., F.C., M-A.DA., P.C., F.VdB. and D.E. contributed to the analysis and the interpretation of the data. A-S.DC., F.VdB. and D.E. have verified the underlying data. All authors critically revised the manuscript for important intellectual content and approved the final version of the manuscript for publication. Funding: The Be-Giant cohort received an unrestricted grant from AbbVie. These financial resources have been used to support data collection and management. AbbVie had no role in study conception and design, data analysis and interpretation, or writing of this manuscript. The principal investigator and his team have full academic freedom and are able to work independently of pharmaceutical industry influence. The principal investigator and his team autonomously decided on data analyses and interpretation, writing of the manuscript, and publication, independent from any industrial contribution or other funding source. The corresponding author has full access to all the data in the study and takes the final responsibility for the decision to submit for publication. Disclosure statement: A-S.DC., T.R., L.D., L. VP., H.C., G.V., R.J., M.D., L.G., I.P., K.T., J.L. and P.C. have nothing to disclose. F.C. reports personal fees from Lilly, UCB and Novartis, outside the submitted work. M-A.DA. reports personal fees from AbbVie, BMS, Novartis, Celgene, Janssen and grants from Pfizer, outside the submitted work. F.VdB. reports grants from AbbVie during the conduct of the study; personal fees from Abbvie, Eli Lilly, Galapagos, Janssen, Novartis, Pfizer and UCB, outside the submitted work. D.E. reports grants from AbbVie during the conduct of the study; personal fees from Abbvie, Eli Lilly, Galapagos, Janssen, Novartis, Pfizer and UCB, outside the submitted work. | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.rights | The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com Free access | - |
dc.subject.other | spondyloarthritis | - |
dc.subject.other | peripheral manifestations | - |
dc.subject.other | clusters | - |
dc.subject.other | trajectories | - |
dc.title | Peripheral manifestations are major determinants of disease phenotype and outcome in new onset spondyloarthritis | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 3288 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 3279 | - |
dc.identifier.volume | 61 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | De Craemer, AS (corresponding author), Ghent Univ Hosp, Div Rheumatol, Dept Internal Med & Pediat, C Heymanslaan 10, B-9000 Ghent, Belgium. | - |
dc.description.notes | annsophie.decraemer@ugent.be | - |
local.publisher.place | GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1093/rheumatology/keab887 | - |
dc.identifier.pmid | 34850859 | - |
dc.identifier.isi | WOS:000789261800001 | - |
dc.contributor.orcid | De Craemer, Ann-Sophie/0000-0001-7062-8934; Varkas, | - |
dc.contributor.orcid | Gaelle/0000-0001-7606-9256 | - |
dc.identifier.eissn | 1462-0332 | - |
local.provider.type | wosris | - |
local.description.affiliation | [De Craemer, Ann-Sophie; Renson, Thomas; Deroo, Liselotte; Varkas, Gaelle; Joos, Rik; Peene, Isabelle; Van den Bosch, Filip; Elewaut, Dirk] Ghent Univ Hosp, Div Rheumatol, Dept Internal Med & Pediat, C Heymanslaan 10, B-9000 Ghent, Belgium. | - |
local.description.affiliation | [De Craemer, Ann-Sophie; Renson, Thomas; Deroo, Liselotte; Carron, Philippe; Van den Bosch, Filip; Elewaut, Dirk] VIB UGent, Ctr Inflammat Res, Zwijnaarde, Belgium. | - |
local.description.affiliation | [Van Praet, Liesbet] AZ Maria Middelares, Dept Rheumatol, Ghent, Belgium. | - |
local.description.affiliation | [Cypers, Heleen; Thevissen, Kristof] Reumactr Genk, Genk, Belgium. | - |
local.description.affiliation | [Joos, Rik] ZNA Jan Palfijn, Dept Rheumatol, Merksem, Belgium. | - |
local.description.affiliation | [Devinck, Mieke] AZ St Lucas, Dept Rheumatol, Assebroek, Belgium. | - |
local.description.affiliation | [Gyselbrecht, Lieve] Algemeen Stedelijk Ziekenhuis ASZ, Dept Rheumatol, Aalst, Belgium. | - |
local.description.affiliation | [Peene, Isabelle] AZ Sint Jan Brugge, Rheumatol, Brugge, Belgium. | - |
local.description.affiliation | [Thevissen, Kristof] Ziekenhuis Oost Limburg ZOL, Dept Rheumatol, Genk, Belgium. | - |
local.description.affiliation | [Costantino, Felicie; D'Agostino, Maria-Antonietta] Univ Paris Saclay, Lab Excellence INFLAMEX, UVSQ, INSERM, Montigny Le Bretonneux, France. | - |
local.description.affiliation | [Costantino, Felicie; D'Agostino, Maria-Antonietta] Ambroise Pare Hosp, AP HP, Dept Rheumatol, Boulogne, France. | - |
local.description.affiliation | [D'Agostino, Maria-Antonietta] Univ Cattolica Sacro Cuore, Policlin Univ Agostino Gemelli IRCSS, Dept Rheumatol, Rome, Italy. | - |
local.description.affiliation | [Lenaerts, Jan] AZ Jessa Hosp, Reuma Inst, Hasselt, Belgium. | - |
local.description.affiliation | [Lenaerts, Jan] AZ Jessa Hosp, Dept Rheumatol, Hasselt, Belgium. | - |
local.description.affiliation | [Carron, Philippe] AZ Alma, Dept Rheumatol, Eeklo, Belgium. | - |
local.uhasselt.international | yes | - |
item.fullcitation | De Craemer, Ann-Sophie; Renson, Thomas; Deroo, Liselotte; VAN PRAET, Liesbet; Cypers, Heleen; Varkas, Gaelle; JOOS, Rik; Devinck, Mieke; Gyselbrecht, Lieve; Peene, Isabelle; THEVISSEN, Kristof; Costantino, Felicie; D'Agostino, Maria-Antonietta; LENAERTS, Jan; Carron, Philippe; VAN DEN BOSCH, Filip & Elewaut, Dirk (2022) Peripheral manifestations are major determinants of disease phenotype and outcome in new onset spondyloarthritis. In: RHEUMATOLOGY, 61 (8) , p. 3279-3288. | - |
item.contributor | De Craemer, Ann-Sophie | - |
item.contributor | Renson, Thomas | - |
item.contributor | Deroo, Liselotte | - |
item.contributor | VAN PRAET, Liesbet | - |
item.contributor | Cypers, Heleen | - |
item.contributor | Varkas, Gaelle | - |
item.contributor | JOOS, Rik | - |
item.contributor | Devinck, Mieke | - |
item.contributor | Gyselbrecht, Lieve | - |
item.contributor | Peene, Isabelle | - |
item.contributor | THEVISSEN, Kristof | - |
item.contributor | Costantino, Felicie | - |
item.contributor | D'Agostino, Maria-Antonietta | - |
item.contributor | LENAERTS, Jan | - |
item.contributor | Carron, Philippe | - |
item.contributor | VAN DEN BOSCH, Filip | - |
item.contributor | Elewaut, Dirk | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 1462-0324 | - |
crisitem.journal.eissn | 1462-0332 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
OP-BRHE210890 3279..3288.pdf | Published version | 572.89 kB | Adobe PDF | View/Open |
WEB OF SCIENCETM
Citations
13
checked on May 12, 2024
Page view(s)
74
checked on Jun 7, 2023
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.