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http://hdl.handle.net/1942/37447
Title: | Unraveling the Rewired Metabolism in Lung Cancer Using Quantitative NMR Metabolomics | Authors: | VANHOVE, Karolien DERVEAUX, Elien MESOTTEN, Liesbet THOMEER, Michiel Criel, Maarten MARIEN, Hanne ADRIAENSENS, Peter |
Issue Date: | 2022 | Publisher: | Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (10) (Art N° 5602) | Abstract: | Lung cancer cells are well documented to rewire their metabolism and energy production networks to enable proliferation and survival in a nutrient-poor and hypoxic environment. Although metabolite profiling of blood plasma and tissue is still emerging in omics approaches, several techniques have shown potential in cancer diagnosis. In this paper, the authors describe the alterations in the metabolic phenotype of lung cancer patients. In addition, we focus on the metabolic cooperation between tumor cells and healthy tissue. Furthermore, the authors discuss how metabolomics could improve the management of lung cancer patients. | Keywords: | NMR (nuclear magnetic resonance);lung cancer;metabolism;Humans;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Phenotype;Lung Neoplasms;Metabolomics | Document URI: | http://hdl.handle.net/1942/37447 | ISSN: | 1661-6596 | e-ISSN: | 1422-0067 | DOI: | 10.3390/ijms23105602 | ISI #: | 000804259200001 | Rights: | Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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ijms-23-05602-v5.pdf | Published version | 1.63 MB | Adobe PDF | View/Open |
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