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Title: | The EXIMIOUS project-Mapping exposure-induced immune effects: connecting the exposome and the immunome | Authors: | Ronsmans, Steven Hougaard, Karin Sorig NAWROT, Tim PLUSQUIN, Michelle Huaux, Francois Cruz, Maria Jesus Moldovan, Horatiu Verpaele, Steven Jayapala, Murali Tunney, Michael Humblet-Baron, Stephanie Dirven, Hubert Nygaard, Unni Cecilie Lindeman, Birgitte Duale, Nur Liston, Adrian Flachs, Esben Meulengracht Kastaniegaard, Kenneth Ketzel, Matthias Goetz, Julia Vanoirbeek, Jeroen Ghosh, Manosij Hoet, Peter H. M. |
Issue Date: | 2022 | Publisher: | LIPPINCOTT WILLIAMS & WILKINS | Source: | Environmental Epidemiology, 6 (1) (Art N° e193) | Abstract: | Immune-mediated, noncommunicable diseases-such as autoimmune and inflammatory diseases-are chronic disorders, in which the interaction between environmental exposures and the immune system plays an important role. The prevalence and societal costs of these diseases are rising in the European Union. The EXIMIOUS consortium-gathering experts in immunology, toxicology, occupational health, clinical medicine, exposure science, epidemiology, bioinformatics, and sensor development-will study eleven European study populations, covering the entire lifespan, including prenatal life. Innovative ways of characterizing and quantifying the exposome will be combined with high-dimensional immunophenotyping and -profiling platforms to map the immune effects (immunome) induced by the exposome. We will use two main approaches that "meet in the middle"-one starting from the exposome, the other starting from health effects. Novel bioinformatics tools, based on systems immunology and machine learning, will be used to integrate and analyze these large datasets to identify immune fingerprints that reflect a person's lifetime exposome or that are early predictors of disease. This will allow researchers, policymakers, and clinicians to grasp the impact of the exposome on the immune system at the level of individuals and populations. | Notes: | Hoet, PHM (corresponding author), Katholieke Univ Leuven, Ctr Environm & Hlth, Herestr 49, B-3000 Leuven, Belgium. peter.hoet@kuleuven.be |
Keywords: | External exposome;Immunome;Immune-mediated diseases;Multi-omics | Document URI: | http://hdl.handle.net/1942/37471 | e-ISSN: | 2474-7882 | DOI: | 10.1097/EE9.0000000000000193 | ISI #: | WOS:000784746300011 | Rights: | 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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