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http://hdl.handle.net/1942/37491
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DC Field | Value | Language |
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dc.contributor.author | Chiaravalloti, Nancy D. | - |
dc.contributor.author | DeLuca, John | - |
dc.contributor.author | Salter, Amber | - |
dc.contributor.author | Amato, Maria Pia | - |
dc.contributor.author | Brichetto, Giampaolo | - |
dc.contributor.author | Chataway, Jeremy | - |
dc.contributor.author | Dalgas, Ulrik | - |
dc.contributor.author | Farrell, Rachel | - |
dc.contributor.author | FEYS, Peter | - |
dc.contributor.author | Filippi, Massimo | - |
dc.contributor.author | Freeman, Jennifer | - |
dc.contributor.author | Inglese, Matilde | - |
dc.contributor.author | Meza, Cecilia | - |
dc.contributor.author | Moore, Nancy B. | - |
dc.contributor.author | Motl, Robert W. | - |
dc.contributor.author | Rocca, Maria Assunta | - |
dc.contributor.author | Sandroff, Brian M. | - |
dc.contributor.author | Cutter, Gary | - |
dc.contributor.author | Feinstein, Anthony | - |
dc.date.accessioned | 2022-06-10T09:05:07Z | - |
dc.date.available | 2022-06-10T09:05:07Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-06-01T14:05:14Z | - |
dc.identifier.citation | Multiple Sclerosis Journal, | - |
dc.identifier.uri | http://hdl.handle.net/1942/37491 | - |
dc.description.abstract | Objective: Processing speed (PS) deficits are the most common cognitive deficits in multiple sclerosis (MS), followed by learning and memory deficits, and are often an early cognitive problem. It has been argued that impaired PS is a primary consequence of MS, which in turn decreases learning. The current analysis examined the association between PS and learning in a large cohort of individuals with progressive MS. Methods: Baseline data from a randomized clinical trial on rehabilitation taking place at 11 centers across North America and Europe were analyzed. Participants included 275 individuals with clinically definite progressive MS (primary, secondary) consented into the trial. Results: Symbol Digit Modalities Test (SDMT) significantly correlated with California Verbal Learning Test-II (CVLT-II) (r = 0.21, p = 0.0003) and Brief Visuospatial Memory Test-Revised (BVMT-R) (r = 0.516, p < 0.0001). Receiver operating characteristic (ROC) analysis of the SDMT z score to distinguish between impaired and non-impaired CVLT-II performance demonstrated an area under the curve (AUC) of 0.61 (95% confidence interval (CI): 0.55-0.68) and a threshold of -1.62. ROC analysis between SDMT and BVMT-R resulted in an AUC of 0.77 (95% CI: 0.71-0.83) and threshold of -1.75 for the SDMT z score to predict impaired BVMT-R. Conclusion: Results indicate little ability beyond chance to predict CVLT-II from SDMT (61%), albeit statistically significant. In contrast, there was a 77% chance that the model could distinguish between impaired and non-impaired BVMT-R. Several potential explanations are discussed. | - |
dc.description.sponsorship | MS Society of Canada [EGID3185] | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.rights | © The Author(s), 2022. Article reuse guidelines: sagepub.com/journalspermissions | - |
dc.subject.other | Progressive multiple sclerosis; BICAMS; cognition; SDMT; processing | - |
dc.subject.other | speed; memory | - |
dc.title | The relationship between processing speed and verbal and non-verbal new learning and memory in progressive multiple sclerosis | - |
dc.type | Journal Contribution | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Chiaravalloti, ND (corresponding author), Kessler Fdn, 120 Eagle Rock Ave,Suite 100, E Hanover, NJ 07936 USA. | - |
dc.description.notes | nchiaravalloti@kesslerfoundation.org | - |
local.publisher.place | 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | Early view | - |
dc.identifier.doi | 10.1177/13524585221088190 | - |
dc.identifier.isi | WOS:000797736100001 | - |
dc.contributor.orcid | amato, Maria Pia/0000-0003-3325-3760; Filippi, | - |
dc.contributor.orcid | Massimo/0000-0002-5485-0479; Chiaravalloti, Nancy/0000-0003-2943-7567; | - |
dc.contributor.orcid | Dalgas, Ulrik/0000-0003-4132-2789; Farrell, Rachel A/0000-0002-2767-3382 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Chiaravalloti, Nancy D.; DeLuca, John; Moore, Nancy B.; Sandroff, Brian M.] Kessler Fdn, 120 Eagle Rock Ave,Suite 100, E Hanover, NJ 07936 USA. | - |
local.description.affiliation | [Chiaravalloti, Nancy D.; DeLuca, John; Sandroff, Brian M.] Rutgers New Jersey Med Sch, Dept Phys Med Rehabil, Newark, NJ 07936 USA. | - |
local.description.affiliation | [Salter, Amber] Univ Texas Southwestern Med Ctr Dallas, Dept Neurol, Sect Stat Planning & Anal, Dallas, TX 75390 USA. | - |
local.description.affiliation | [Amato, Maria Pia] Univ Florence, Dept NEUROFARBA, Sect Neurosci, Florence, Italy. | - |
local.description.affiliation | [Amato, Maria Pia] IRCCS Fdn Don Carlo Gnocchi, Florence, Italy. | - |
local.description.affiliation | [Brichetto, Giampaolo] Italian Multiple Sclerosis Fdn FISM, Sci Res Area, Genoa, Italy. | - |
local.description.affiliation | [Brichetto, Giampaolo] Italian Multiple Sclerosis Soc, AISM Rehabil Serv, Genoa, Italy. | - |
local.description.affiliation | [Chataway, Jeremy] UCL, Fac Brain Sci, UCL Queen Sq Inst Neurol, Queen Sq Multiple Sclerosis Ctr,Dept Neuroinflamm, London, England. | - |
local.description.affiliation | [Chataway, Jeremy; Farrell, Rachel] Univ Coll London Hosp, Natl Inst Hlth Res, Biomed Res Ctr, London, England. | - |
local.description.affiliation | [Dalgas, Ulrik] Aarhus Univ, Dept Publ Hlth, Exercise Biol, Aarhus, Denmark. | - |
local.description.affiliation | [Farrell, Rachel] Natl Hosp Neurol & Neurosurg, Dept Neurorehabil, London, England. | - |
local.description.affiliation | [Farrell, Rachel] UCL Queen Sq Inst Neurol, Dept Neuroinflammat, London, England. | - |
local.description.affiliation | [Feys, Peter] Hasselt Univ, Fac Rehabil Sci, REVAL, Diepenbeek, Belgium. | - |
local.description.affiliation | [Filippi, Massimo; Rocca, Maria Assunta] IRCCS San Raffaele Sci Inst, Div Neurosci, Neuroimaging Res Unit, Milan, Italy. | - |
local.description.affiliation | [Filippi, Massimo; Rocca, Maria Assunta] IRCCS San Raffaele Sci Inst, Neurol Unit, Milan, Italy. | - |
local.description.affiliation | [Filippi, Massimo] IRCCS San Raffaele Sci Inst, Neurophysiol Serv, Milan, Italy. | - |
local.description.affiliation | [Filippi, Massimo; Rocca, Maria Assunta] Univ Vita Salute San Raffaele, Milan, Italy. | - |
local.description.affiliation | [Freeman, Jennifer] Univ Plymouth, Fac Hlth, Sch Hlth Profess, Plymouth, Devon, England. | - |
local.description.affiliation | [Inglese, Matilde] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy. | - |
local.description.affiliation | [Inglese, Matilde] Univ Genoa, Ctr Excellence Biomed Res, Genoa, Italy. | - |
local.description.affiliation | [Inglese, Matilde] IRCCS Osped Policlin San Martino IRCCS, Genoa, Italy. | - |
local.description.affiliation | [Meza, Cecilia; Feinstein, Anthony] Univ Toronto, Dept Psychiat, Toronto, ON, Canada. | - |
local.description.affiliation | [Meza, Cecilia; Feinstein, Anthony] Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada. | - |
local.description.affiliation | [Motl, Robert W.] Univ Illinois, Coll Appl Hlth Sci, Dept Kinesiol & Nutr, Chicago, IL USA. | - |
local.description.affiliation | [Cutter, Gary] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL 35294 USA. | - |
local.uhasselt.international | yes | - |
item.contributor | Chiaravalloti, Nancy D. | - |
item.contributor | DeLuca, John | - |
item.contributor | Salter, Amber | - |
item.contributor | Amato, Maria Pia | - |
item.contributor | Brichetto, Giampaolo | - |
item.contributor | Chataway, Jeremy | - |
item.contributor | Dalgas, Ulrik | - |
item.contributor | Farrell, Rachel | - |
item.contributor | FEYS, Peter | - |
item.contributor | Filippi, Massimo | - |
item.contributor | Freeman, Jennifer | - |
item.contributor | Inglese, Matilde | - |
item.contributor | Meza, Cecilia | - |
item.contributor | Moore, Nancy B. | - |
item.contributor | Motl, Robert W. | - |
item.contributor | Rocca, Maria Assunta | - |
item.contributor | Sandroff, Brian M. | - |
item.contributor | Cutter, Gary | - |
item.contributor | Feinstein, Anthony | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2023 | - |
item.fullcitation | Chiaravalloti, Nancy D.; DeLuca, John; Salter, Amber; Amato, Maria Pia; Brichetto, Giampaolo; Chataway, Jeremy; Dalgas, Ulrik; Farrell, Rachel; FEYS, Peter; Filippi, Massimo; Freeman, Jennifer; Inglese, Matilde; Meza, Cecilia; Moore, Nancy B.; Motl, Robert W.; Rocca, Maria Assunta; Sandroff, Brian M.; Cutter, Gary & Feinstein, Anthony (2022) The relationship between processing speed and verbal and non-verbal new learning and memory in progressive multiple sclerosis. In: Multiple Sclerosis Journal,. | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 1352-4585 | - |
crisitem.journal.eissn | 1477-0970 | - |
Appears in Collections: | Research publications |
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13524585221088190.pdf Restricted Access | Published version | 638.55 kB | Adobe PDF | View/Open Request a copy |
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