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http://hdl.handle.net/1942/37529
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DC Field | Value | Language |
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dc.contributor.author | Devos , Timothy | - |
dc.contributor.author | Van Thillo, Quentin | - |
dc.contributor.author | Compernolle, Veerle | - |
dc.contributor.author | Najdovski, Tome | - |
dc.contributor.author | Romano, Marta | - |
dc.contributor.author | Dauby, Nicolas | - |
dc.contributor.author | Jadot, Laurent | - |
dc.contributor.author | Leys, Mathias | - |
dc.contributor.author | Maillart, Evelyne | - |
dc.contributor.author | Loof, Sarah | - |
dc.contributor.author | Seyler , Lucie | - |
dc.contributor.author | Moonen , Martial | - |
dc.contributor.author | Moutschen, Michel | - |
dc.contributor.author | Van Regenmortel, Niels | - |
dc.contributor.author | Arien, Kevin K. | - |
dc.contributor.author | Barbezange, Cyril | - |
dc.contributor.author | Betrains, Albrecht | - |
dc.contributor.author | Garigliany, Mutien | - |
dc.contributor.author | Engelen, Matthias M. | - |
dc.contributor.author | Gyselinck, Iwein | - |
dc.contributor.author | Maes, Piet | - |
dc.contributor.author | Schauwvlieghe, Alexander | - |
dc.contributor.author | Liesenborghs, Laurens | - |
dc.contributor.author | Belmans, Ann | - |
dc.contributor.author | Verhamme, Peter | - |
dc.contributor.author | Meyfroidt, Geert | - |
dc.date.accessioned | 2022-06-15T09:07:50Z | - |
dc.date.available | 2022-06-15T09:07:50Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-06-01T14:31:13Z | - |
dc.identifier.citation | EUROPEAN RESPIRATORY JOURNAL, 59 (2) (Art N° 2101724) | - |
dc.identifier.uri | http://hdl.handle.net/1942/37529 | - |
dc.description.abstract | Background Several randomised clinical trials have studied convalescent plasma for coronavirus disease 2019 (COVID-19) using different protocols, with different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralising antibody titres, at different time-points and severities of illness. Methods In the prospective multicentre DAWn-plasma trial, adult patients hospitalised with COVID-19 were randomised to 4 units of open-label convalescent plasma combined with standard of care (intervention group) or standard of care alone (control group). Plasma from donors with neutralising antibody titres (50% neutralisation titre (NT50)) >= 1/320 was the product of choice for the study. Results Between 2 May 2020 and 26 January 2021, 320 patients were randomised to convalescent plasma and 163 patients to the control group according to a 2:1 allocation scheme. A median (interquartile range) volume of 884 (806-906) mL) convalescent plasma was administered and 80.68% of the units came from donors with neutralising antibody titres (NT50) >= 1/320. Median time from onset of symptoms to randomisation was 7 days. The proportion of patients alive and free of mechanical ventilation on day 15 was not different between both groups (convalescent plasma 83.74% (n=267) versus control 84.05% (n=137)) (OR 0.99, 95% CI 0.59-1.66; p=0.9772). The intervention did not change the natural course of antibody titres. The number of serious or severe adverse events was similar in both study arms and transfusion-related side-effects were reported in 19 out of 320 patients in the intervention group (5.94%). Conclusions Transfusion of 4 units of convalescent plasma with high neutralising antibody titres early in hospitalised COVID-19 patients did not result in a significant improvement of clinical status or reduced mortality. | - |
dc.description.sponsorship | This work was supported by Fonds Wetenschappelijk Onderzoek (grant: 1843118N) and Belgian Health Care Knowledge Centre (KCE). Funding information for this article has been deposited with the Crossref Funder Registry | - |
dc.language.iso | en | - |
dc.publisher | EUROPEAN RESPIRATORY SOC JOURNALS LTD | - |
dc.rights | ©The authors 2022. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org This article has an editorial commentary: https://doi.org/10.1183/ 13993003.02076-2021 | - |
dc.subject.other | Adult | - |
dc.subject.other | Antibodies, Neutralizing | - |
dc.subject.other | Antibodies, Viral | - |
dc.subject.other | Hospitalization | - |
dc.subject.other | Humans | - |
dc.subject.other | Prospective Studies | - |
dc.subject.other | Treatment Outcome | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | Immunization, Passive | - |
dc.title | Early high antibody titre convalescent plasma for hospitalised COVID-19 patients: DAWn-plasma | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 2 | - |
dc.identifier.volume | 59 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Meyfroidt, G (corresponding author), Katholieke Univ Leuven, Dept Intens Care Med, Dept Cellular & Mol Med, Lab Intens Care Med,Univ Hosp Leuven, Leuven, Belgium. | - |
dc.description.notes | geert.meyfroidt@uzleuven.be | - |
local.publisher.place | 442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 2101724 | - |
local.class | dsPublValOverrule/internal_author_not_expected | - |
dc.identifier.doi | 10.1183/13993003.01724-2021 | - |
dc.identifier.pmid | 34446469 | - |
dc.identifier.isi | WOS:000798166900002 | - |
dc.contributor.orcid | Gyselinck, Iwein/0000-0002-4068-7228; Barbezange, | - |
dc.contributor.orcid | Cyril/0000-0001-9606-2983; Dauby, Nicolas/0000-0002-7697-6849; | - |
dc.contributor.orcid | Liesenborghs, Laurens/0000-0001-5616-8548 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Devos, Timothy] Katholieke Univ Leuven, Lab Mol Immunol, Dept Hematol, Univ Hosp Leuven,Rega Inst, Leuven, Belgium. | - |
local.description.affiliation | [Devos, Timothy] Katholieke Univ Leuven, Lab Mol Immunol, Dept Microbiol & Immunol, Rega Inst, Leuven, Belgium. | - |
local.description.affiliation | [Van Thillo, Quentin] Katholieke Univ Leuven, Vlaams Inst Biotechnol VIB, Ctr Canc Biol, Leuven, Belgium. | - |
local.description.affiliation | [Van Thillo, Quentin] Katholieke Univ Leuven, Ctr Human Genet, Leuven, Belgium. | - |
local.description.affiliation | [Compernolle, Veerle] Blood Serv, Belgian Red Cross, Mechelen, Belgium. | - |
local.description.affiliation | [Compernolle, Veerle] Univ Ghent, Fac Med & Hlth Sci, Ghent, Belgium. | - |
local.description.affiliation | [Najdovski, Tome] Serv Sang, Belgian Red Cross, Namur, Belgium. | - |
local.description.affiliation | [Romano, Marta] Sciensano, Immune Response Serv, Infect Dis Humans Sci Directorate, Brussels, Belgium. | - |
local.description.affiliation | [Dauby, Nicolas] Univ Libre Bruxelles ULB, Sch Publ Hlth, Inst Med Immunol, Dept Infect Dis,CHU St Pierre, Brussels, Belgium. | - |
local.description.affiliation | [Jadot, Laurent] CHC Mt Legia, Dept Anesthesiol & Intens Care Med, Liege, Belgium. | - |
local.description.affiliation | [Jadot, Laurent] CHC Mt Legia, Dept Infect Dis, Liege, Belgium. | - |
local.description.affiliation | [Leys, Mathias] AZ Groeninge, Dept Pulm Med, Kortrijk, Belgium. | - |
local.description.affiliation | [Maillart, Evelyne] Brugmann Univ Hosp, Dept Infect Dis, Brussels, Belgium. | - |
local.description.affiliation | [Loof, Sarah] AZ Maria Middelares Gent, Dept Resp Med, Ghent, Belgium. | - |
local.description.affiliation | [Loof, Sarah] AZ Sint Vincentius Deinze, Dept Resp Med, Deinze, Belgium. | - |
local.description.affiliation | [Seyler, Lucie] UZ Brussel Hosp, Dept Infect Dis & Internal Med, Brussels, Belgium. | - |
local.description.affiliation | [Moonen, Martial] Ctr Hosp Reg CHR, Dept Internal Med & Infect Dis, Liege, Belgium. | - |
local.description.affiliation | [Moutschen, Michel] CHU Liege, Infect Dis & Gen Internal Med, Liege, Belgium. | - |
local.description.affiliation | [Van Regenmortel, Niels] Ziekenhuis Netwerk Antwerpen, Dept Intens Care Med, Campus Stuivenberg, Antwerp, Belgium. | - |
local.description.affiliation | [Arien, Kevin K.] Univ Antwerp, Inst Trop Med Antwerp, Dept Biomed Sci, Virol Unit, Antwerp, Belgium. | - |
local.description.affiliation | [Barbezange, Cyril] Sciensano, Natl Influenza Ctr, Brussels, Belgium. | - |
local.description.affiliation | [Betrains, Albrecht] Katholieke Univ Leuven, Dept Gen Internal Med, Dept Microbiol Immunol & Transplantat, Univ Hosp Leuven, Leuven, Belgium. | - |
local.description.affiliation | [Garigliany, Mutien] Univ Liege, Fac Vet Med, Anim Pathol, Liege, Belgium. | - |
local.description.affiliation | [Engelen, Matthias M.; Verhamme, Peter] UZ & KU Leuven, Dept Cardiovasc Sci, Leuven, Belgium. | - |
local.description.affiliation | [Gyselinck, Iwein] Resp Dis UZ Leuven, Lab Resp Dis & Thorac Surg BREATHE, Dept CHROMETA, Leuven, Belgium. | - |
local.description.affiliation | [Maes, Piet] Katholieke Univ Leuven, Rega Inst Med Res, Clin & Epidemiol Virol, Leuven, Belgium. | - |
local.description.affiliation | [Schauwvlieghe, Alexander] Ghent Univ Hosp, Dept Haematol, Ghent, Belgium. | - |
local.description.affiliation | [Liesenborghs, Laurens] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Lab Virol & Chemotherapy, Rega Inst Med Res, Leuven, Belgium. | - |
local.description.affiliation | [Belmans, Ann] Katholieke Univ Leuven, I BioStat, Leuven, Belgium. | - |
local.description.affiliation | [Belmans, Ann] Univ Hasselt, Hasselt, Belgium. | - |
local.description.affiliation | [Meyfroidt, Geert] Katholieke Univ Leuven, Dept Intens Care Med, Dept Cellular & Mol Med, Lab Intens Care Med,Univ Hosp Leuven, Leuven, Belgium. | - |
local.uhasselt.international | no | - |
item.validation | ecoom 2023 | - |
item.contributor | Devos , Timothy | - |
item.contributor | Van Thillo, Quentin | - |
item.contributor | Compernolle, Veerle | - |
item.contributor | Najdovski, Tome | - |
item.contributor | Romano, Marta | - |
item.contributor | Dauby, Nicolas | - |
item.contributor | Jadot, Laurent | - |
item.contributor | Leys, Mathias | - |
item.contributor | Maillart, Evelyne | - |
item.contributor | Loof, Sarah | - |
item.contributor | Seyler , Lucie | - |
item.contributor | Moonen , Martial | - |
item.contributor | Moutschen, Michel | - |
item.contributor | Van Regenmortel, Niels | - |
item.contributor | Arien, Kevin K. | - |
item.contributor | Barbezange, Cyril | - |
item.contributor | Betrains, Albrecht | - |
item.contributor | Garigliany, Mutien | - |
item.contributor | Engelen, Matthias M. | - |
item.contributor | Gyselinck, Iwein | - |
item.contributor | Maes, Piet | - |
item.contributor | Schauwvlieghe, Alexander | - |
item.contributor | Liesenborghs, Laurens | - |
item.contributor | Belmans, Ann | - |
item.contributor | Verhamme, Peter | - |
item.contributor | Meyfroidt, Geert | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
item.fullcitation | Devos , Timothy; Van Thillo, Quentin; Compernolle, Veerle; Najdovski, Tome; Romano, Marta; Dauby, Nicolas; Jadot, Laurent; Leys, Mathias; Maillart, Evelyne; Loof, Sarah; Seyler , Lucie; Moonen , Martial; Moutschen, Michel; Van Regenmortel, Niels; Arien, Kevin K.; Barbezange, Cyril; Betrains, Albrecht; Garigliany, Mutien; Engelen, Matthias M.; Gyselinck, Iwein; Maes, Piet; Schauwvlieghe, Alexander; Liesenborghs, Laurens; Belmans, Ann; Verhamme, Peter & Meyfroidt, Geert (2022) Early high antibody titre convalescent plasma for hospitalised COVID-19 patients: DAWn-plasma. In: EUROPEAN RESPIRATORY JOURNAL, 59 (2) (Art N° 2101724). | - |
crisitem.journal.issn | 0903-1936 | - |
crisitem.journal.eissn | 1399-3003 | - |
Appears in Collections: | Research publications |
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Early high antibody titre convalescent plasma for hospitalised COVID-19 patients_ DAWn-plasma.pdf | Published version | 740.08 kB | Adobe PDF | View/Open |
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