Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/37552
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dc.contributor.authorKuehl, L.K.-
dc.contributor.authorDe Punder, K-
dc.contributor.authorDeuter, C.E.-
dc.contributor.authorMARTENS, Dries-
dc.contributor.authorHeim, C.-
dc.contributor.authorOTT, C.-
dc.contributor.authorWingenfeld, K.-
dc.contributor.authorEntringer, S.-
dc.date.accessioned2022-06-20T12:13:27Z-
dc.date.available2022-06-20T12:13:27Z-
dc.date.issued2022-
dc.date.submitted2022-04-25T14:12:01Z-
dc.identifier.citationPSYCHONEUROENDOCRINOLOGY, 142 (Art N° 105762)-
dc.identifier.issn0306-4530-
dc.identifier.urihttp://hdl.handle.net/1942/37552-
dc.description.abstractMajor depressive disorder (MDD) and adverse childhood experiences (ACE) are associated with poor physical and mental health in adulthood. One underlying mechanism might be accelerated cellular aging. For example, both conditions, MDD and ACE, have been related to a biological marker of cellular aging, accelerated shortening of telomere length (TL). Since MDD and ACE are confounded in many studies, we aimed with the current study to further disentangle the effects of MDD and ACE on TL using a full-factorial design including four carefully diagnosed groups of healthy participants and MDD patients with and without ACE (total N = 90, all without use of antidepressants). As dependent variable, TL was assessed in leukocytes. We found no group differences based on MDD and ACE exposure in TL. While TL was negatively associated with age and male sex, TL was not associated with any measure of severity of MDD, ACE or current stress. One possible explanation for our null result may be the comparatively good physical health status of our sample. Future research is needed to elucidate the relation of TL, MDD and ACE, taking potential effect modification by medication intake and physical health status into account-
dc.description.sponsorshipThis work was supported by a grant of the German Research Foundation KU3106/2-1 awarded to LK, KW, and CO. KdP’s, CH’s and SE’s funding was supported by grants from the German Federal Ministry of Education and Research 01KR1301A, the European Research Council ERC-STG-67073 and US PHS (NIH) grants R01 HD-065825, R01 HD-060628 and R01 AG-050455-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subject.otherTelomere length-
dc.subject.otherMajor depressive disorder-
dc.subject.otherChildhood trauma-
dc.subject.otherEarly life stress-
dc.subject.otherStress-
dc.titleTelomere length in individuals with and without major depression and adverse childhood experiences-
dc.typeJournal Contribution-
dc.identifier.volume142-
local.bibliographicCitation.jcatA1-
local.publisher.placeTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr105762-
dc.identifier.doi10.1016/j.psyneuen.2022.105762-
dc.identifier.isi000818071100010-
dc.identifier.eissn1873-3360-
local.provider.typeCrossRef-
local.uhasselt.internationalyes-
item.contributorKuehl, L.K.-
item.contributorDe Punder, K-
item.contributorDeuter, C.E.-
item.contributorMARTENS, Dries-
item.contributorHeim, C.-
item.contributorOTT, C.-
item.contributorWingenfeld, K.-
item.contributorEntringer, S.-
item.validationecoom 2023-
item.fullcitationKuehl, L.K.; De Punder, K; Deuter, C.E.; MARTENS, Dries; Heim, C.; OTT, C.; Wingenfeld, K. & Entringer, S. (2022) Telomere length in individuals with and without major depression and adverse childhood experiences. In: PSYCHONEUROENDOCRINOLOGY, 142 (Art N° 105762).-
item.accessRightsRestricted Access-
item.fulltextWith Fulltext-
crisitem.journal.issn0306-4530-
crisitem.journal.eissn1873-3360-
Appears in Collections:Research publications
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