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http://hdl.handle.net/1942/37592
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DC Field | Value | Language |
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dc.contributor.author | STASSEN, Jan | - |
dc.contributor.author | Ewe, See Hooi | - |
dc.contributor.author | Butcher, Steele C. | - |
dc.contributor.author | Amanullah, Mohammed R. | - |
dc.contributor.author | Mertens, Bart J. | - |
dc.contributor.author | Hirasawa, Kensuke | - |
dc.contributor.author | Singh, Gurpreet K. | - |
dc.contributor.author | Sin, Kenny Y. | - |
dc.contributor.author | Ding, Zee Pin | - |
dc.contributor.author | Pio, Stephan M. | - |
dc.contributor.author | Sia, Ching-Hui | - |
dc.contributor.author | Chew, Nicholas | - |
dc.contributor.author | Kong, William | - |
dc.contributor.author | Poh, Kian Keong | - |
dc.contributor.author | Cohen, David | - |
dc.contributor.author | Genereux, Philippe | - |
dc.contributor.author | Leon, Martin B. | - |
dc.contributor.author | Marsan, Nina Ajmone | - |
dc.contributor.author | Delgado, Victoria | - |
dc.contributor.author | Bax, Jeroen J. | - |
dc.date.accessioned | 2022-06-29T08:22:37Z | - |
dc.date.available | 2022-06-29T08:22:37Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-06-24T11:56:25Z | - |
dc.identifier.citation | HEART, 108 (17), p. 1401-1407 | - |
dc.identifier.uri | http://hdl.handle.net/1942/37592 | - |
dc.description.abstract | Objective To investigate the prognostic impact of left ventricular (LV) diastolic dysfunction in patients with moderate aortic stenosis (AS) and preserved LV systolic function. Methods Patients with a first diagnosis of moderate AS (aortic valve area >1.0 and <= 1.5 cm(2)) and preserved LV systolic function (LV ejection fraction >= 50%) were identified. LV diastolic function was evaluated using echocardiographic criteria according to the 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging guidelines. Clinical outcomes were defined as all-cause mortality and a composite of all-cause mortality and aortic valve replacement (AVR). Results Of 1247 patients (age 74 +/- 10 years, 47% men), 535 (43%) had LV diastolic dysfunction at baseline. Patients with LV diastolic dysfunction showed significantly higher mortality rates at 1-year, 3-year and 5-year follow-up (13%, 30% and 41%, respectively) when compared with patients with normal LV diastolic function (6%, 17% and 29%, respectively) (p<0.001). On multivariable analysis, LV diastolic dysfunction was independently associated with all-cause mortality (HR 1.368; 95% CI 1.085 to 1.725; p=0.008) and the composite endpoint of all-cause mortality and AVR (HR 1.241; 95% CI 1.035 to 1.488; p=0.020). Conclusions LV diastolic dysfunction is independently associated with all-cause mortality and the composite endpoint of all-cause mortality and AVR in patients with moderate AS and preserved LV systolic function. Assessment of LV diastolic function therefore contributes significantly to the risk stratification of patients with moderate AS. Future clinical trials are needed to investigate whether patients with moderate AS and LV diastolic dysfunction may benefit from earlier valve intervention. | - |
dc.description.sponsorship | JS received funding from the European Society of Cardiology (ESC Training Grant App000064741). SCB received funding from the European Society of Cardiology (ESC Research Grant App000080404). | - |
dc.language.iso | en | - |
dc.publisher | BMJ PUBLISHING GROUP | - |
dc.rights | Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ. | - |
dc.subject.other | Echocardiography | - |
dc.subject.other | Transcatheter Aortic Valve Replacement | - |
dc.subject.other | Heart Valve Prosthesis Implantation | - |
dc.subject.other | Aortic Valve Stenosis | - |
dc.title | Prognostic implications of left ventricular diastolic dysfunction in moderate aortic stenosis | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1407 | - |
dc.identifier.issue | 17 | - |
dc.identifier.spage | 1401 | - |
dc.identifier.volume | 108 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Bax, JJ (corresponding author), Leiden Univ, Dept Cardiol, Med Ctr, Leiden, Zuid Holland, Netherlands. | - |
dc.description.notes | j.j.bax@lumc.nl | - |
local.publisher.place | BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1136/heartjnl-2022-320886 | - |
dc.identifier.pmid | 35688475 | - |
dc.identifier.isi | WOS:000810552600001 | - |
dc.contributor.orcid | Stassen, Jan/0000-0001-9745-5498 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Stassen, Jan; Butcher, Steele C.; Hirasawa, Kensuke; Singh, Gurpreet K.; Pio, Stephan M.; Marsan, Nina Ajmone; Delgado, Victoria; Bax, Jeroen J.] Leiden Univ, Dept Cardiol, Med Ctr, Leiden, Zuid Holland, Netherlands. | - |
local.description.affiliation | [Stassen, Jan] Jesse Hosp, Dept Cardiol, Hasselt, Belgium. | - |
local.description.affiliation | [Ewe, See Hooi; Amanullah, Mohammed R.; Ding, Zee Pin] Natl Heart Ctr Singapore, Dept Cardiol, Singapore, Singapore. | - |
local.description.affiliation | [Mertens, Bart J.] Leiden Univ, Dept Bioinformat, Med Ctr, Leiden, Netherlands. | - |
local.description.affiliation | [Sin, Kenny Y.] Natl Heart Ctr Singapore, Dept Cardiothorac Surg, Singapore, Singapore. | - |
local.description.affiliation | [Sia, Ching-Hui; Chew, Nicholas; Kong, William; Poh, Kian Keong] Natl Univ Heart Ctr, Dept Cardiol, Singapore, Singapore. | - |
local.description.affiliation | [Cohen, David] St Francis Hosp Heart Ctr, Dept Cardiol, Roslyn, NY USA. | - |
local.description.affiliation | [Genereux, Philippe] Morristown Med Ctr, Dept Cardiol, Morristown, NJ USA. | - |
local.description.affiliation | [Leon, Martin B.] Columbia Univ, Dept Cardiol, Med Ctr, New York, NY USA. | - |
local.description.affiliation | [Bax, Jeroen J.] Turku Heart Ctr, Dept Cardiol, Turku, Finland. | - |
local.uhasselt.international | yes | - |
item.fullcitation | STASSEN, Jan; Ewe, See Hooi; Butcher, Steele C.; Amanullah, Mohammed R.; Mertens, Bart J.; Hirasawa, Kensuke; Singh, Gurpreet K.; Sin, Kenny Y.; Ding, Zee Pin; Pio, Stephan M.; Sia, Ching-Hui; Chew, Nicholas; Kong, William; Poh, Kian Keong; Cohen, David; Genereux, Philippe; Leon, Martin B.; Marsan, Nina Ajmone; Delgado, Victoria & Bax, Jeroen J. (2022) Prognostic implications of left ventricular diastolic dysfunction in moderate aortic stenosis. In: HEART, 108 (17), p. 1401-1407. | - |
item.fulltext | With Fulltext | - |
item.contributor | STASSEN, Jan | - |
item.contributor | Ewe, See Hooi | - |
item.contributor | Butcher, Steele C. | - |
item.contributor | Amanullah, Mohammed R. | - |
item.contributor | Mertens, Bart J. | - |
item.contributor | Hirasawa, Kensuke | - |
item.contributor | Singh, Gurpreet K. | - |
item.contributor | Sin, Kenny Y. | - |
item.contributor | Ding, Zee Pin | - |
item.contributor | Pio, Stephan M. | - |
item.contributor | Sia, Ching-Hui | - |
item.contributor | Chew, Nicholas | - |
item.contributor | Kong, William | - |
item.contributor | Poh, Kian Keong | - |
item.contributor | Cohen, David | - |
item.contributor | Genereux, Philippe | - |
item.contributor | Leon, Martin B. | - |
item.contributor | Marsan, Nina Ajmone | - |
item.contributor | Delgado, Victoria | - |
item.contributor | Bax, Jeroen J. | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 1355-6037 | - |
crisitem.journal.eissn | 1468-201X | - |
Appears in Collections: | Research publications |
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1401.full.pdf Restricted Access | Published version | 1.05 MB | Adobe PDF | View/Open Request a copy |
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