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DC Field | Value | Language |
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dc.contributor.author | Vandekerckhove, Ines | - |
dc.contributor.author | van den Hauwe, Marleen | - |
dc.contributor.author | De Beukelaer, Nathalie | - |
dc.contributor.author | Stoop, Elze | - |
dc.contributor.author | Goudriaan, Marije | - |
dc.contributor.author | Delporte, Margaux | - |
dc.contributor.author | MOLENBERGHS, Geert | - |
dc.contributor.author | Van Campenhout , Anja | - |
dc.contributor.author | De Waele, Liesbeth | - |
dc.contributor.author | Goemans, Nathalie | - |
dc.contributor.author | De Groote , Friedl | - |
dc.contributor.author | Desloovere, Kaat | - |
dc.date.accessioned | 2022-07-07T08:45:23Z | - |
dc.date.available | 2022-07-07T08:45:23Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-07-05T11:21:01Z | - |
dc.identifier.citation | Frontiers in human neuroscience, 16 (Art N° 861136) | - |
dc.identifier.uri | http://hdl.handle.net/1942/37663 | - |
dc.description.abstract | Prolonging ambulation is an important treatment goal in children with Duchenne muscular dystrophy (DMD). Three-dimensional gait analysis (3DGA) could provide sensitive parameters to study the efficacy of clinical trials aiming to preserve ambulation. However, quantitative descriptions of the natural history of gait features in DMD are first required. The overall goal was to provide a full delineation of the progressive gait pathology in children with DMD, covering the entire period of ambulation, by performing a so-called mixed cross-sectional longitudinal study. Firstly, to make our results comparable with previous literature, we aimed to cross-sectionally compare 31 predefined gait features between children with DMD and a typically developing (TD) database (1). Secondly, we aimed to explore the longitudinal changes in the 31 predefined gait features in growing boys with DMD using follow-up 3DGA sessions (2). 3DGA-sessions (n = 124) at self-selected speed were collected in 27 boys with DMD (baseline age: 4.6-15 years). They were repeatedly measured over a varying follow-up period (range: 6 months-5 years). The TD group consisted of 27 children (age: 5.4-15.6 years). Per measurement session, the spatiotemporal parameters, and the kinematic and kinetic waveforms were averaged over the selected gait cycles. From the averaged waveforms, discrete gait features (e.g., maxima and minima) were extracted. Mann-Whitney U tests were performed to cross-sectionally analyze the differences between DMD at baseline and TD (1). Linear mixed effect models were performed to assess the changes in gait features in the same group of children with DMD from both a longitudinal (i.e., increasing time) as well as a cross-sectional perspective (i.e., increasing baseline age) (2). At baseline, the boys with DMD differed from the TD children in 17 gait features. Additionally, 21 gait features evolved longitudinally when following-up the same boys with DMD and 25 gait features presented a significant cross-sectional baseline age-effect. The current study quantitatively described the longitudinal alterations in gait features in boys with DMD, thereby providing detailed insight into how DMD gait deteriorates. Additionally, our results highlight that gait features extracted from 3DGA are promising outcome measures for future clinical trials to quantify the efficacy of novel therapeutic strategies. | - |
dc.description.sponsorship | This work was supported by the Duchenne Parent Project NL (17.011) and by the Research Foundation - Flanders (FWOVlaanderen) through a research fellowship to IV (1188921N). MG was funded by the Dutch Organization for Scientific Research (NWO) VIDI grant (no. 016.156.346 FirSTeps), the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Program (no. 715945 Learn2Walk), and the Johanna Kinderfonds and Kinderrevalidatie Fonds Adriaanstichting (no. 20200028). We thank all the children and parents for their participation in this study and the colleagues of UZ Leuven for helping to recruit the boys with DMD. | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.rights | 2022 Vandekerckhove, Van den Hauwe, De Beukelaer, Stoop, Goudriaan, Delporte, Molenberghs, Van Campenhout, De Waele, Goemans, De Groote and Desloovere. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | - |
dc.subject.other | Duchenne muscular dystrophyty | - |
dc.subject.other | pically developing children | - |
dc.subject.other | three-dimensional gait analysis | - |
dc.subject.other | gait pattern | - |
dc.subject.other | longitudinal study | - |
dc.subject.other | mixed models for repeated measures | - |
dc.title | Longitudinal Alterations in Gait Features in Growing Children With Duchenne Muscular Dystrophy | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 16 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Desloovere, K (corresponding author), Katholieke Univ Leuven, Dept Rehabil Sci, Leuven, Belgium.; Desloovere, K (corresponding author), Univ Hosp Leuven, Clin Mot Anal Lab, Leuven, Belgium. | - |
dc.description.notes | kaat.desloovere@kuleuven.be | - |
local.publisher.place | AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 861136 | - |
local.type.programme | H2020 | - |
local.relation.h2020 | 715945 | - |
dc.identifier.doi | 10.3389/fnhum.2022.861136 | - |
dc.identifier.pmid | 35721358 | - |
dc.identifier.isi | 000811842700001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Vandekerckhove, Ines; van den Hauwe, Marleen; De Beukelaer, Nathalie; Stoop, Elze; Desloovere, Kaat] Katholieke Univ Leuven, Dept Rehabil Sci, Leuven, Belgium. | - |
local.description.affiliation | [van den Hauwe, Marleen; De Waele, Liesbeth; Goemans, Nathalie] Univ Hosp Leuven, Dept Child Neurol, Leuven, Belgium. | - |
local.description.affiliation | [Stoop, Elze; Van Campenhout, Anja; Desloovere, Kaat] Univ Hosp Leuven, Clin Mot Anal Lab, Leuven, Belgium. | - |
local.description.affiliation | [Goudriaan, Marije] Vrije Univ Amsterdam, Dept Human Movement Sci, Amsterdam, Netherlands. | - |
local.description.affiliation | [Delporte, Margaux; Molenberghs, Geert] Katholieke Univ Leuven, Interuniv Inst Biostat & Stat Bioinformat I BIOSTA, Leuven, Belgium. | - |
local.description.affiliation | [Molenberghs, Geert] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat I BIOSTA, Data Sci Inst, Hasselt, Belgium. | - |
local.description.affiliation | [Van Campenhout, Anja; De Waele, Liesbeth; Goemans, Nathalie] Katholieke Univ Leuven, Dept Dev & Regenerat, Leuven, Belgium. | - |
local.description.affiliation | [Van Campenhout, Anja] Univ Hosp Leuven, Dept Orthoped, Leuven, Belgium. | - |
local.description.affiliation | [De Groote, Friedl] Katholieke Univ Leuven, Dept Movement Sci, Leuven, Belgium. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Vandekerckhove, Ines; van den Hauwe, Marleen; De Beukelaer, Nathalie; Stoop, Elze; Goudriaan, Marije; Delporte, Margaux; MOLENBERGHS, Geert; Van Campenhout , Anja; De Waele, Liesbeth; Goemans, Nathalie; De Groote , Friedl & Desloovere, Kaat (2022) Longitudinal Alterations in Gait Features in Growing Children With Duchenne Muscular Dystrophy. In: Frontiers in human neuroscience, 16 (Art N° 861136). | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2023 | - |
item.contributor | Vandekerckhove, Ines | - |
item.contributor | van den Hauwe, Marleen | - |
item.contributor | De Beukelaer, Nathalie | - |
item.contributor | Stoop, Elze | - |
item.contributor | Goudriaan, Marije | - |
item.contributor | Delporte, Margaux | - |
item.contributor | MOLENBERGHS, Geert | - |
item.contributor | Van Campenhout , Anja | - |
item.contributor | De Waele, Liesbeth | - |
item.contributor | Goemans, Nathalie | - |
item.contributor | De Groote , Friedl | - |
item.contributor | Desloovere, Kaat | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 1662-5161 | - |
crisitem.journal.eissn | 1662-5161 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Longitudinal Alterations in Gait Features in Growing Children With Duchenne Muscular Dystrophy.pdf | Published version | 10.46 MB | Adobe PDF | View/Open |
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