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http://hdl.handle.net/1942/37686
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DC Field | Value | Language |
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dc.contributor.author | Ploumen, EH | - |
dc.contributor.author | Buiten, RA | - |
dc.contributor.author | Zocca, P | - |
dc.contributor.author | Doggen, CJM | - |
dc.contributor.author | Jessurun, GAJ | - |
dc.contributor.author | Schotborgh, CE | - |
dc.contributor.author | Roguin, A | - |
dc.contributor.author | Danse, PW | - |
dc.contributor.author | BENIT, Edouard | - |
dc.contributor.author | Aminian, A | - |
dc.contributor.author | Anthonio, RL | - |
dc.contributor.author | Somi, S | - |
dc.contributor.author | Linssen, GCM | - |
dc.contributor.author | Hartmann, M | - |
dc.contributor.author | Kok, MM | - |
dc.contributor.author | von Birgelen, C | - |
dc.date.accessioned | 2022-07-08T12:44:12Z | - |
dc.date.available | 2022-07-08T12:44:12Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2022-07-06T13:45:11Z | - |
dc.identifier.citation | Catheterization and cardiovascular interventions, 98 (2) , p. E188 -E196 | - |
dc.identifier.uri | http://hdl.handle.net/1942/37686 | - |
dc.description.abstract | Objectives To compare 2-year outcome following treatment with drug-eluting stents (DES) for acute myocardial infarction (MI) versus non-MI clinical syndromes. In acute MI patients, a stent-level comparison was performed, comparing Resolute Onyx versus Orsiro stents.Background In patients presenting with acute MI, higher adverse event rates have been reported. So far, no clinical results >1 year have been published of acute MI patients treated with Resolute Onyx.Methods This post-hoc analysis of the randomized BIONYX trial(NCT02508714) assessed the main outcome target vessel failure (TVF: cardiac death, target vessel MI, or target vessel revascularization) with Kaplan-Meier methods.Results Of all 2,488 trial participants, acute MI patients (n = 1,275[51.2%]) were significantly younger and had less comorbidities than non-MI patients (n = 1,213[48.8%]). TVF rates were lower in acute MI patients (77/1,275[6.1%] vs. 103/1,213[8.6%], HR:0.70, 95%-CI 0.52-0.94; p(log-rank) = 0.02), mainly driven by target vessel revascularization (4.1 vs. 6.1%, p(log-rank) = 0.03). Multivariate analysis showed no independent association of clinical syndrome with TVF (adjusted-HR: 0.81, 95%-CI 0.60-1.10; p = .17). In MI patients treated with Resolute Onyx (n = 626) versus Orsiro (n = 649), there was no difference in TVF (6.2 vs. 6.1%; p(log-rank) = 0.97) and its components. There was only 1(0.2%) definite-or-probable stent thrombosis in RO-ZES and 8(1.2%) in O-SES (p = .053).Conclusions Two years after treatment with thin-strut DES in this randomized trial, patients treated for acute MI had lower adverse event rates than non-MI patients. Yet, these findings were mainly attributable to between-group differences in patient and lesion characteristics. In patients who underwent PCI for acute MI, both Resolute Onyx and Orsiro showed favorable and similar 2-year outcomes. | - |
dc.description.sponsorship | Biotronik; Medtronic | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License | - |
dc.subject.other | clinical trials | - |
dc.subject.other | drug‐ | - |
dc.subject.other | eluting stent | - |
dc.subject.other | myocardial infarction | - |
dc.subject.other | percutaneous coronary intervention | - |
dc.title | Acute myocardial infarction treated with novel Resolute Onyx and Orsiro stents in the randomized BIONYX trial | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | E196 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | E188 | - |
dc.identifier.volume | 98 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1002/ccd.29594 | - |
dc.identifier.isi | 000627272100001 | - |
local.provider.type | Web of Science | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.contributor | Ploumen, EH | - |
item.contributor | Buiten, RA | - |
item.contributor | Zocca, P | - |
item.contributor | Doggen, CJM | - |
item.contributor | Jessurun, GAJ | - |
item.contributor | Schotborgh, CE | - |
item.contributor | Roguin, A | - |
item.contributor | Danse, PW | - |
item.contributor | BENIT, Edouard | - |
item.contributor | Aminian, A | - |
item.contributor | Anthonio, RL | - |
item.contributor | Somi, S | - |
item.contributor | Linssen, GCM | - |
item.contributor | Hartmann, M | - |
item.contributor | Kok, MM | - |
item.contributor | von Birgelen, C | - |
item.accessRights | Open Access | - |
item.fullcitation | Ploumen, EH; Buiten, RA; Zocca, P; Doggen, CJM; Jessurun, GAJ; Schotborgh, CE; Roguin, A; Danse, PW; BENIT, Edouard; Aminian, A; Anthonio, RL; Somi, S; Linssen, GCM; Hartmann, M; Kok, MM & von Birgelen, C (2021) Acute myocardial infarction treated with novel Resolute Onyx and Orsiro stents in the randomized BIONYX trial. In: Catheterization and cardiovascular interventions, 98 (2) , p. E188 -E196. | - |
crisitem.journal.issn | 1522-1946 | - |
crisitem.journal.eissn | 1522-726X | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Cathet Cardio Intervent - 2021 - Ploumen - Acute myocardial infarction treated with novel Resolute Onyx and Orsiro stents.pdf | Published version | 2.11 MB | Adobe PDF | View/Open |
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