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Title: | Treating diabetic all-comers with contemporary drug-eluting stents: Prespecified comparisons from the BIO-RESORT and the BIONYX randomized trials | Authors: | Ploumen, EH Buiten, RA Kok, MM Doggen, CJM Roguin, A Jessurun, GAJ Schotborgh, CE Danse, PW BENIT, Edouard Aminian, A van Houwelingen, KG Stoel, MG Scholte, M Hartmanna, M Linssen, GCM Zocca, P von Birgelen, C |
Issue Date: | 2021 | Publisher: | ELSEVIER IRELAND LTD | Source: | International journal of cardiology (print), 325 , p. 37 -44 | Abstract: | Background: Patients with diabetes have more extensive coronary disease, resulting in higher risks of adverse clinical events following stenting. In all-corner patients, contemporary DES have shown excellent safety and efficacy, but data on diabetic patients are scarce. Separately for the BIO-RESORT and BIONYX trials, we assessed the 2-year clinical outcomes of diabetic patients, treated with various contemporary drug-eluting stents (DES).Methods: We performed two prespecified secondary analyses of two randomized DES trials, which both stratified for diabetes. The main endpoint was target vessel failure (WI), a composite of cardiac death, target vessel myocardial infarction, or target vessel revascularization. Follow-up was finished before the COVID-19 pandemic.Results: In BIO-RESORT, 624/3514 (17.8%) had diabetes: 211 received Orsiro sirolimus-eluting stents (SES), 203 Synergy everolimus-eluting stents (EES), and 210 Resolute Integrity zotarolimus-eluting stents (RI-ZES). TVF did not differ between SES (10.2%) and EES (10.0%) versus RI-ZES (12.7%) (SES vs. RI-ZES HR:0.78, 95%-CI [0.44-1.40]; p = 0.40, EES vs. RI-ZES HR:0.79, 95%-CI [0.44-1.40]; p = 0.42). In BIONYX, 510/2488 (20.5%) patients had diabetes: 250 received SES and 260 Resolute Onyx zotarolimus-eluting stents (RO-ZES). There was no difference in TVF between SES (10.7%) versus RO-ZES (12.2%) (HR:0.88, 95%-CI [0.52-148]; p = 0.63).Conclusions: There was no difference in 2-year clinical outcome among patients with diabetes, who were treated with SES, or EES. versus RI-ZES. In addition there was no difference in clinical outcome in diabetic patients, who were treated with SES versus RO-ZES. These findings may be considered as a signal of safety and efficacy of the studied DES in patients with diabetes. (C) 2020 The Author(s). Published by Elsevier B.V. | Keywords: | Percutaneous coronary intervention;Randomized clinical trial;Drug-eluting stents;Diabetes mellitus | Document URI: | http://hdl.handle.net/1942/37707 | ISSN: | 0167-5273 | e-ISSN: | 1874-1754 | DOI: | 10.1016/j.ijcard.2020.10.051 | ISI #: | 000623745900006 | Rights: | © 2020 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Treating diabetic all-comers with contemporary drug-eluting stents_ Prespecified comparisons from the BIO-RESORT and the BIONYX randomized trials.pdf | Published version | 1.64 MB | Adobe PDF | View/Open |
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