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http://hdl.handle.net/1942/37746
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DC Field | Value | Language |
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dc.contributor.author | Goos, Tinne | - |
dc.contributor.author | Verleden, Stijn | - |
dc.contributor.author | De Sadeleer, Laurens | - |
dc.contributor.author | Van Herck, Anke | - |
dc.contributor.author | Sacreas, Annelore | - |
dc.contributor.author | Vanstapel, Arno | - |
dc.contributor.author | KAES, Janne | - |
dc.contributor.author | Geudens, Vincent | - |
dc.contributor.author | Aelbrecht, Celine | - |
dc.contributor.author | RUTTENS, David | - |
dc.contributor.author | Lambrechts, Diether | - |
dc.contributor.author | Vermeer, Sascha | - |
dc.contributor.author | Ceulemans, Laurens | - |
dc.contributor.author | Raemdonck, Dirk | - |
dc.contributor.author | Godinas, Laurent | - |
dc.contributor.author | Yserbyt, Jonas | - |
dc.contributor.author | Vanaudenaerde, Bart | - |
dc.contributor.author | Verleden, Geert | - |
dc.contributor.author | Vos, Robin | - |
dc.contributor.author | Wuyts, Wim | - |
dc.date.accessioned | 2022-07-15T12:10:15Z | - |
dc.date.available | 2022-07-15T12:10:15Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-06-27T08:04:47Z | - |
dc.identifier.citation | Transplant international, 35 (Art N° 10159) | - |
dc.identifier.issn | 0934-0874 | - |
dc.identifier.uri | http://hdl.handle.net/1942/37746 | - |
dc.description.abstract | The MUC5B promoter polymorphism (rs35705950) has been associated with interstitial lung disease (ILD) and with prolonged pre-transplant survival in idiopathic pulmonary fibrosis (IPF), but no information is available regarding its prevalence in other respiratory diseases and its influence on post-transplant outcome. We included the Leuven lung transplantation cohort between 1991 and 2015 (n = 801). We assessed the minor allele frequency (MAF) of the MUC5B variant in the entire study cohort and investigated the influence of recipient MUC5B promoter polymorphism on post-transplant outcome in patients who were transplanted after 2004. MUC5B was successfully genotyped in 746 patients. The MAF was significantly higher in ILD (17.6%) compared to chronic obstructive pulmonary disease (COPD)/emphysema (9.3%), cystic fibrosis (CF)/bronchiectasis (BRECT) (7.5%) and pulmonary hypertension (PHT) (7.4%) (p < 0.001). No association was observed between rs35705950 and chronic lung allograft dysfunction (CLAD)/graft loss in the ILD population [CLAD: HR 1.37 95% CI (0.70-2.68); graft loss: HR 1.02 95% CI (0.55-1.89)], nor the entire study cohort [CLAD: HR 0.96 95% CI (0.69-1.34); graft loss: HR 0.97 95% CI (0.70-1.35)]. The MUC5B promoter polymorphism is a very specific predictive factor for the presence of pulmonary fibrosis | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.subject.other | Abbreviations: AR, acute rejection | - |
dc.subject.other | AZA, azathioprine | - |
dc.subject.other | BRECT, bronchiectasis | - |
dc.subject.other | CF, cystic fibrosis | - |
dc.subject.other | cHP, chronic hypersen- sitivity pneumonitis | - |
dc.subject.other | CI, confidence interval | - |
dc.subject.other | CLAD, chronic lung allograft dysfunction | - |
dc.subject.other | CMV, cytomegalovirus | - |
dc.subject.other | COPD, | - |
dc.title | The MUC5B Promoter Polymorphism is Not Associated With Non-ILD Chronic Respiratory Diseases or Post-transplant Outcome | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 35 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 10159 | - |
dc.identifier.doi | 10.3389/ti.2022.10159 | - |
dc.identifier.isi | 000822657800001 | - |
dc.identifier.eissn | 1432-2277 | - |
local.provider.type | - | |
local.uhasselt.international | no | - |
item.fullcitation | Goos, Tinne; Verleden, Stijn; De Sadeleer, Laurens; Van Herck, Anke; Sacreas, Annelore; Vanstapel, Arno; KAES, Janne; Geudens, Vincent; Aelbrecht, Celine; RUTTENS, David; Lambrechts, Diether; Vermeer, Sascha; Ceulemans, Laurens; Raemdonck, Dirk; Godinas, Laurent; Yserbyt, Jonas; Vanaudenaerde, Bart; Verleden, Geert; Vos, Robin & Wuyts, Wim (2022) The MUC5B Promoter Polymorphism is Not Associated With Non-ILD Chronic Respiratory Diseases or Post-transplant Outcome. In: Transplant international, 35 (Art N° 10159). | - |
item.accessRights | Open Access | - |
item.contributor | Goos, Tinne | - |
item.contributor | Verleden, Stijn | - |
item.contributor | De Sadeleer, Laurens | - |
item.contributor | Van Herck, Anke | - |
item.contributor | Sacreas, Annelore | - |
item.contributor | Vanstapel, Arno | - |
item.contributor | KAES, Janne | - |
item.contributor | Geudens, Vincent | - |
item.contributor | Aelbrecht, Celine | - |
item.contributor | RUTTENS, David | - |
item.contributor | Lambrechts, Diether | - |
item.contributor | Vermeer, Sascha | - |
item.contributor | Ceulemans, Laurens | - |
item.contributor | Raemdonck, Dirk | - |
item.contributor | Godinas, Laurent | - |
item.contributor | Yserbyt, Jonas | - |
item.contributor | Vanaudenaerde, Bart | - |
item.contributor | Verleden, Geert | - |
item.contributor | Vos, Robin | - |
item.contributor | Wuyts, Wim | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2023 | - |
crisitem.journal.issn | 0934-0874 | - |
crisitem.journal.eissn | 1432-2277 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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ti-35-10159.pdf | Published version | 1.65 MB | Adobe PDF | View/Open |
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