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http://hdl.handle.net/1942/37803
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DC Field | Value | Language |
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dc.contributor.author | Hara, Hironori | - |
dc.contributor.author | Serruys, Patrick W. | - |
dc.contributor.author | O'Leary, Neil | - |
dc.contributor.author | Gao, Chao | - |
dc.contributor.author | Murray, Alicia | - |
dc.contributor.author | Breslin, Elaine | - |
dc.contributor.author | Garg, Scot | - |
dc.contributor.author | Bureau, Christophe | - |
dc.contributor.author | Reiber, Johan H. C. | - |
dc.contributor.author | Barbato, Emanuele | - |
dc.contributor.author | Aminian, Adel | - |
dc.contributor.author | Janssens, Luc | - |
dc.contributor.author | Rosseel, Liesbeth | - |
dc.contributor.author | BENIT, Edouard | - |
dc.contributor.author | Campo, Gianluca | - |
dc.contributor.author | Guiducci, Vincenzo | - |
dc.contributor.author | Casella, Gianni | - |
dc.contributor.author | Santarelli, Andrea | - |
dc.contributor.author | Franze, Alfonso | - |
dc.contributor.author | Diaz, Victor Alfonso Jimenez | - |
dc.contributor.author | Iniguez, Andres | - |
dc.contributor.author | Brugaletta, Salvatore | - |
dc.contributor.author | Sabate, Manel | - |
dc.contributor.author | Amat-Santos, Ignacio J. | - |
dc.contributor.author | Amoroso, Giovanni | - |
dc.contributor.author | Wykrzykowska, Joanna | - |
dc.contributor.author | von Birgelen, Clemens | - |
dc.contributor.author | Somi, Samer | - |
dc.contributor.author | Liu , Tommy | - |
dc.contributor.author | Hofma, Sjoerd H. | - |
dc.contributor.author | Curzen, Nick | - |
dc.contributor.author | Trillo, Ramiro | - |
dc.contributor.author | Ocaranza, Raymundo | - |
dc.contributor.author | Mathur, Anthony | - |
dc.contributor.author | Smits, Pieter C. | - |
dc.contributor.author | Escaned, Javier | - |
dc.contributor.author | Baumbach, Andreas | - |
dc.contributor.author | Wijns , William | - |
dc.contributor.author | Sharif, Faisal | - |
dc.contributor.author | Onuma, Yoshinobu | - |
dc.date.accessioned | 2022-07-25T09:30:49Z | - |
dc.date.available | 2022-07-25T09:30:49Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-07-19T11:52:36Z | - |
dc.identifier.citation | The American heart journal, 246 , p. 32 -43 | - |
dc.identifier.uri | http://hdl.handle.net/1942/37803 | - |
dc.description.abstract | Background Current ESC guidelines recommend the use of intra-coronary pressure guidewires for functional assessment of intermediate-grade coronary stenoses. Angiography-derived quantitative flow ratio (QFR) is a novel method of assessing these stenoses, and guiding percutaneous coronary intervention (PCI). Methods/Design The PIONEER IV trial is a prospective, all-comers, multi-center trial, which will randomize 2,540 patients in a 1:1 ratio to PCI guided by angiography-derived physiology or usual care, with unrestricted use in both arms of the Healing-Targeted Supreme sirolimus-eluting stent (HT Supreme). The stent's fast, biologically healthy, and robust endothelial coverage allows for short dual-antiplatelet therapy (DAPT); hence the antiplatelet regimen of choice is 1-month DAPT, followed by ticagrelor monotherapy. In the angiography-derived physiology guided arm, lesions will be functionally assessed using on-line QFR, with stenting indicated in lesions with a QFR <= 0.80. Post-stenting, QFR will be repeated in the stented vessel(s), with post-dilatation or additional stenting recommended if the QFR < 0.91 distal to the stent, or if the delta QFR (across the stent) is > 0.05. Usual care PCI is performed according to standard clinical practice. The primary endpoint is a non-inferiority comparison of the patient-oriented composite endpoint (POCE) of all-cause death, any stroke, any myocardial infarction, or any clinically, and physiologically driven revascularization with a non-inferiority risk-difference margin of 3.2%, at 1-year post-procedure. Clinical follow-up will be up to 3 years. Summary The PIONEER IV trial aims to demonstrate non-inferiority of QFR-guided PCI to usual care PCI with respect to POCE at 1-year in patients treated with HT Supreme stents and ticagrelor monotherapy. | - |
dc.description.sponsorship | The PIONEER IV trial is an investigator-initiated trial sponsored by The National University of Ireland Galway, which received funding from SINOMED (Tianjin, China). | - |
dc.language.iso | en | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.rights | 2022 Elsevier Inc. All rights reserved | - |
dc.subject.other | Coronary Angiography | - |
dc.subject.other | Humans | - |
dc.subject.other | Prospective Studies | - |
dc.subject.other | Stents | - |
dc.subject.other | Ticagrelor | - |
dc.subject.other | Treatment Outcome | - |
dc.subject.other | Coronary Artery Disease | - |
dc.subject.other | Drug-Eluting Stents | - |
dc.subject.other | Percutaneous Coronary Intervention | - |
dc.title | Angiography-derived physiology guidance vs usual care in an All-comers PCI population treated with the healing-targeted supreme stent and Ticagrelor monotherapy: PIONEER IV trial design | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 43 | - |
dc.identifier.spage | 32 | - |
dc.identifier.volume | 246 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Serruys, PW (corresponding author), Natl Univ Ireland Galway NUIG, Dept Cardiol, 46 Univ Rd, Galway H91 TK33, Ireland. | - |
dc.description.notes | patrick.w.j.c.serruys@gmail.com | - |
local.publisher.place | 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.ahj.2021.12.018 | - |
dc.identifier.pmid | 34990582 | - |
dc.identifier.isi | 000806125400004 | - |
dc.contributor.orcid | O'Leary, Neil/0000-0002-2765-7016; Curzen, Nick/0000-0001-9651-7829; | - |
dc.contributor.orcid | Gao, Chao/0000-0002-0390-8060; Garg, Scot/0000-0002-8911-0278; Bureau, | - |
dc.contributor.orcid | Christophe/0000-0002-7669-7698; Serruys, Patrick W./0000-0002-9636-1104 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Hara, Hironori] Univ Amsterdam, Acad Med Ctr, Dept Cardiol, Amsterdam, Netherlands. | - |
local.description.affiliation | [Hara, Hironori; Serruys, Patrick W.; Gao, Chao; Sharif, Faisal; Onuma, Yoshinobu] Natl Univ Ireland Galway NUIG, Dept Cardiol, 46 Univ Rd, Galway H91 TK33, Ireland. | - |
local.description.affiliation | [Serruys, Patrick W.] Imperial Coll London, NHLI, London, England. | - |
local.description.affiliation | [O'Leary, Neil; Murray, Alicia; Breslin, Elaine] Natl Univ Ireland, Coll Med Nursing & Hlth Sci, CORRIB Res Ctr, Galway, Ireland. | - |
local.description.affiliation | [Gao, Chao] Radboudumc, Dept Cardiol, Nijmegen, Netherlands. | - |
local.description.affiliation | [Gao, Chao] Xijing Hosp, Dept Cardiol, Xian, Peoples R China. | - |
local.description.affiliation | [Garg, Scot] Royal Blackburn Hosp, Dept Cardiol, Blackburn, Lancs, England. | - |
local.description.affiliation | [Bureau, Christophe] AlchiMed SAS, Paris, France. | - |
local.description.affiliation | [Reiber, Johan H. C.] Leiden Univ, Dept Radiol, Med Ctr, Leiden, Netherlands. | - |
local.description.affiliation | [Barbato, Emanuele] OLV Clin, Cardiovasc Res Ctr Aalst, Aalst, Belgium. | - |
local.description.affiliation | [Barbato, Emanuele] Univ Federico II, Dept Adv Biomed Sci, Naples, Italy. | - |
local.description.affiliation | [Aminian, Adel] Ctr Hosp Univ Charleroi, Dept Cardiol, Charleroi, Belgium. | - |
local.description.affiliation | [Janssens, Luc] Imeldaziekenhuis, Dept Cardiol, Bonheiden, Belgium. | - |
local.description.affiliation | [Rosseel, Liesbeth] Algemeen Stedelijk Ziekenhuis, Dept Cardiol, Aalst, Belgium. | - |
local.description.affiliation | [Benit, Edouard] Hartctr Jessa Ziekenhuis, Campus Virga Jesse, Hasselt, Belgium. | - |
local.description.affiliation | [Campo, Gianluca] Azienda Osped Univ Ferrara, Cardiol Unit, Cona, Italy. | - |
local.description.affiliation | [Guiducci, Vincenzo] Azienda USL IRCCS Reggio Emilia, Reggio Emilia, Italy. | - |
local.description.affiliation | [Casella, Gianni] Osped Maggiore Bologna, UOC Cardiol, Bologna, Italy. | - |
local.description.affiliation | [Santarelli, Andrea] Infermi Hosp, Cardiol Unit, Rimini, Italy. | - |
local.description.affiliation | [Franze, Alfonso] San Luigi Gonzaga Univ Hosp Orbassano, Intervent Cardiol Unit, Turin, Italy. | - |
local.description.affiliation | [Franze, Alfonso] Rivoli Infermi Hosp Rivoli, Turin, Italy. | - |
local.description.affiliation | [Diaz, Victor Alfonso Jimenez; Iniguez, Andres] Hosp Univ Vigo, Dept Cardiol, Vigo, Spain. | - |
local.description.affiliation | [Iniguez, Andres] Hosp Univ Alvaro Cunqueiro, Dept Cardiol, Vigo, Spain. | - |
local.description.affiliation | [Brugaletta, Salvatore; Sabate, Manel] Hosp Clin Barcelona, Clin Cardiovasc Inst, Inst Invest Biomed August Pi & Sunyer, Cardiol Dept,IDIBAPS, Barcelona, Spain. | - |
local.description.affiliation | [Amat-Santos, Ignacio J.] Hosp Clin Valladolid, Cardiol Dept, CIBERCV, Valladolid, Spain. | - |
local.description.affiliation | [Amoroso, Giovanni] OLVG, Amsterdam, Netherlands. | - |
local.description.affiliation | [Wykrzykowska, Joanna] Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands. | - |
local.description.affiliation | [von Birgelen, Clemens] Med Spectrum Twente, Dept Cardiol, Thoraxctr Twente, Enschede, Netherlands. | - |
local.description.affiliation | [von Birgelen, Clemens] Univ Twente, Fac BMS, Tech Med Ctr, Dept Hlth Technol & Serv Res, Enschede, Netherlands. | - |
local.description.affiliation | [Somi, Samer; Liu, Tommy] Haga Hosp, Dept Cardiol, The Hague, Netherlands. | - |
local.description.affiliation | [Hofma, Sjoerd H.] Med Ctr Leeuwarden, Dept Cardiol, Leeuwarden, Netherlands. | - |
local.description.affiliation | [Curzen, Nick] Univ Southampton, Fac Med, Southampton, Hants, England. | - |
local.description.affiliation | [Curzen, Nick] Univ Hosp Southampton NHS Trust, Southampton, Hants, England. | - |
local.description.affiliation | [Trillo, Ramiro] Univ Clin Hosp, Dept Cardiol, CIBERCV, Santiago De Compostela, Spain. | - |
local.description.affiliation | [Ocaranza, Raymundo] Lucus Augusti Univ Hosp, Intervent Cardiol Sect, Lugo, Spain. | - |
local.description.affiliation | [Mathur, Anthony] Barts Hlth NHS Trust, Barts Heart Ctr, Barts Intervent Grp, London, England. | - |
local.description.affiliation | [Mathur, Anthony; Baumbach, Andreas] Queen Mary Univ London, Ctr Cardiovasc Med & Devices, William Harvey Res Inst, London, England. | - |
local.description.affiliation | [Smits, Pieter C.] Maasstad Ziekenhuis, Rotterdam, Netherlands. | - |
local.description.affiliation | [Escaned, Javier] Univ Complutense Madrid, Hosp Clin San Carlos, IDISCC, Madrid, Spain. | - |
local.description.affiliation | [Baumbach, Andreas] Barts Heart Ctr, London, England. | - |
local.description.affiliation | [Baumbach, Andreas] Yale Univ, Sch Med, New Haven, CT USA. | - |
local.description.affiliation | [Wijns, William] NUIG, Lambe Inst Translat Med & Curam, Galway, Ireland. | - |
local.description.affiliation | [Sharif, Faisal] NUIG, SFI Infrastruct Funding, Galway, Ireland. | - |
local.uhasselt.international | yes | - |
item.contributor | Hara, Hironori | - |
item.contributor | Serruys, Patrick W. | - |
item.contributor | O'Leary, Neil | - |
item.contributor | Gao, Chao | - |
item.contributor | Murray, Alicia | - |
item.contributor | Breslin, Elaine | - |
item.contributor | Garg, Scot | - |
item.contributor | Bureau, Christophe | - |
item.contributor | Reiber, Johan H. C. | - |
item.contributor | Barbato, Emanuele | - |
item.contributor | Aminian, Adel | - |
item.contributor | Janssens, Luc | - |
item.contributor | Rosseel, Liesbeth | - |
item.contributor | BENIT, Edouard | - |
item.contributor | Campo, Gianluca | - |
item.contributor | Guiducci, Vincenzo | - |
item.contributor | Casella, Gianni | - |
item.contributor | Santarelli, Andrea | - |
item.contributor | Franze, Alfonso | - |
item.contributor | Diaz, Victor Alfonso Jimenez | - |
item.contributor | Iniguez, Andres | - |
item.contributor | Brugaletta, Salvatore | - |
item.contributor | Sabate, Manel | - |
item.contributor | Amat-Santos, Ignacio J. | - |
item.contributor | Amoroso, Giovanni | - |
item.contributor | Wykrzykowska, Joanna | - |
item.contributor | von Birgelen, Clemens | - |
item.contributor | Somi, Samer | - |
item.contributor | Liu , Tommy | - |
item.contributor | Hofma, Sjoerd H. | - |
item.contributor | Curzen, Nick | - |
item.contributor | Trillo, Ramiro | - |
item.contributor | Ocaranza, Raymundo | - |
item.contributor | Mathur, Anthony | - |
item.contributor | Smits, Pieter C. | - |
item.contributor | Escaned, Javier | - |
item.contributor | Baumbach, Andreas | - |
item.contributor | Wijns , William | - |
item.contributor | Sharif, Faisal | - |
item.contributor | Onuma, Yoshinobu | - |
item.accessRights | Restricted Access | - |
item.fullcitation | Hara, Hironori; Serruys, Patrick W.; O'Leary, Neil; Gao, Chao; Murray, Alicia; Breslin, Elaine; Garg, Scot; Bureau, Christophe; Reiber, Johan H. C.; Barbato, Emanuele; Aminian, Adel; Janssens, Luc; Rosseel, Liesbeth; BENIT, Edouard; Campo, Gianluca; Guiducci, Vincenzo; Casella, Gianni; Santarelli, Andrea; Franze, Alfonso; Diaz, Victor Alfonso Jimenez; Iniguez, Andres; Brugaletta, Salvatore; Sabate, Manel; Amat-Santos, Ignacio J.; Amoroso, Giovanni; Wykrzykowska, Joanna; von Birgelen, Clemens; Somi, Samer; Liu , Tommy; Hofma, Sjoerd H.; Curzen, Nick; Trillo, Ramiro; Ocaranza, Raymundo; Mathur, Anthony; Smits, Pieter C.; Escaned, Javier; Baumbach, Andreas; Wijns , William; Sharif, Faisal & Onuma, Yoshinobu (2022) Angiography-derived physiology guidance vs usual care in an All-comers PCI population treated with the healing-targeted supreme stent and Ticagrelor monotherapy: PIONEER IV trial design. In: The American heart journal, 246 , p. 32 -43. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0002-8703 | - |
crisitem.journal.eissn | 1097-6744 | - |
Appears in Collections: | Research publications |
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Angiography-derived physiology guidance vs usual care in an All-comers PCI population treated with the healing-targeted supreme stent and Ticagrelor monotherapy_ PIONEER IV trial design.pdf Restricted Access | Published version | 1.44 MB | Adobe PDF | View/Open Request a copy |
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