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http://hdl.handle.net/1942/37806
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DC Field | Value | Language |
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dc.contributor.author | Grieten, Jef | - |
dc.contributor.author | Chevalier, Pierre | - |
dc.contributor.author | Lesenne, Anouk | - |
dc.contributor.author | Ernon, Ludovic | - |
dc.contributor.author | Vandermeulen , Elly | - |
dc.contributor.author | Panis , Elke | - |
dc.contributor.author | MESOTTEN, Dieter | - |
dc.date.accessioned | 2022-07-25T10:22:05Z | - |
dc.date.available | 2022-07-25T10:22:05Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-07-19T10:34:47Z | - |
dc.identifier.citation | Acta neurologica belgica, 122 (5), p. 1281-1287 | - |
dc.identifier.uri | http://hdl.handle.net/1942/37806 | - |
dc.description.abstract | Introduction Acute ischaemic stroke is associated with important mortality, morbidity, and healthcare-related costs. Age, pre-stroke functionality and stroke severity are important contributors to functional outcome. Stroke patients also risk developing infections during hospitalization. We sought to explore possible predictors of post-stroke infections and the relationship of post-stroke infection with healthcare-related costs and functional outcome. Methods This single-centre retrospective study included 530 patients treated for ischaemic stroke between January 2017 and February 2019. Antibiotics' administration was used as a proxy for post-stroke infection. Functional outcome at 90 days was assessed by the modified Rankin Scale (mRS). Total healthcare-related costs were recorded for the index hospital stay. Multivariable analysis for post-stroke infection was done with the independent factors sex, age, pre-stroke mRS, National Institutes of Health Stroke Scale (NIHSS) and diabetes mellitus. Results Twenty percent of patients had a post-stroke infection. NIHSS (OR 1.10, 95%CI 1.06-1.13, p < 0.0001) and diabetes mellitus (OR 2.18, 95%CI 1.28-3.71, p = 0.0042) were independent predictors for post-stroke infection. Mean total healthcare-related costs were 15,374 euro (SD 19,968; IQR 3,380-18,165), with a mean of 31,061 euro (SD 29,995; IQR 12,584-42,843) in patients with infection, compared to 11,406 euro (SD 13,987; IQR 3,083-12,726) in patients without (p < 0.0001). Median 90-days mRS was 5 (IQR 3-6) in patients with infection versus 1 (IQR 0-3.5) in patients without (p < 0.0001). Conclusions In patients, admitted for acute ischaemic stroke, stroke severity and diabetes mellitus were identified as the main predictors for post-stroke infection. Hospital-acquired infections were associated with increased costs and worse functional outcome. | - |
dc.description.sponsorship | Interreg/SafePAT: project number Euregio Maas-Rijn EMR90. Province of Limburg Belgium. Limburg Clinical Research Center (LCRC)- Anaesthesiology/Neurology Programme. | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.rights | The Author(s) under exclusive licence to Belgian Neurological Society 2022 | - |
dc.subject.other | Cerebrovascular disorders | - |
dc.subject.other | Stroke | - |
dc.subject.other | Infection | - |
dc.subject.other | Costs | - |
dc.title | Hospital-acquired infections after acute ischaemic stroke and its association with healthcare-related costs and functional outcome | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 5 | - |
dc.identifier.volume | 122 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Mesotten, D (corresponding author), ZOL Genk, Crit Care Dept, Dept Anaesthesiol & Intens Care Med, Schiepse Bos 6, B-3600 Genk, Belgium.; Mesotten, D (corresponding author), Hasselt Univ, Fac Med & Life Sci, Diepenbeek, Belgium. | - |
dc.description.notes | dieter.mesotten@zol.be | - |
local.publisher.place | TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1007/s13760-022-01977-2 | - |
dc.identifier.pmid | 35773572 | - |
dc.identifier.isi | 000819276000001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Grieten, Jef; Lesenne, Anouk; Vandermeulen, Elly; Mesotten, Dieter] ZOL Genk, Crit Care Dept, Dept Anaesthesiol & Intens Care Med, Schiepse Bos 6, B-3600 Genk, Belgium. | - |
local.description.affiliation | [Chevalier, Pierre] IQVIA, Dept Real World Solut, Zaventem, Belgium. | - |
local.description.affiliation | [Ernon, Ludovic] ZOL Genk, Dept Neurol, Genk, Belgium. | - |
local.description.affiliation | [Panis, Elke] ZOL Genk, Finance & Accounting Dept, Genk, Belgium. | - |
local.description.affiliation | [Mesotten, Dieter] Hasselt Univ, Fac Med & Life Sci, Diepenbeek, Belgium. | - |
local.description.affiliation | [Grieten, Jef] Univ Hosp Antwerp, Dept Anaesthesiol, Antwerp, Belgium. | - |
local.description.affiliation | [Lesenne, Anouk] Univ Hosp Ghent, Dept Anaesthesiol, Ghent, Belgium. | - |
local.uhasselt.international | no | - |
item.contributor | Grieten, Jef | - |
item.contributor | Chevalier, Pierre | - |
item.contributor | Lesenne, Anouk | - |
item.contributor | Ernon, Ludovic | - |
item.contributor | Vandermeulen , Elly | - |
item.contributor | Panis , Elke | - |
item.contributor | MESOTTEN, Dieter | - |
item.fullcitation | Grieten, Jef; Chevalier, Pierre; Lesenne, Anouk; Ernon, Ludovic; Vandermeulen , Elly; Panis , Elke & MESOTTEN, Dieter (2022) Hospital-acquired infections after acute ischaemic stroke and its association with healthcare-related costs and functional outcome. In: Acta neurologica belgica, 122 (5), p. 1281-1287. | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2023 | - |
crisitem.journal.issn | 0300-9009 | - |
crisitem.journal.eissn | 2240-2993 | - |
Appears in Collections: | Research publications |
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s13760-022-01977-2.pdf Restricted Access | Published version | 563.49 kB | Adobe PDF | View/Open Request a copy |
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