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http://hdl.handle.net/1942/37816
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DC Field | Value | Language |
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dc.contributor.author | Hassanabadi, Negar Sadeghi | - |
dc.contributor.author | BROUX, Bieke | - |
dc.contributor.author | Marinovic, Sonja | - |
dc.contributor.author | Gotthardt, Dagmar | - |
dc.date.accessioned | 2022-07-27T08:46:28Z | - |
dc.date.available | 2022-07-27T08:46:28Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-07-19T10:33:58Z | - |
dc.identifier.citation | Frontiers in immunology, 13 (Art N° 909275) | - |
dc.identifier.uri | http://hdl.handle.net/1942/37816 | - |
dc.description.abstract | Multiple sclerosis (MS) is a highly debilitating autoimmune disease affecting millions of individuals worldwide. Although classically viewed as T-cell mediated disease, the role of innate lymphoid cells (ILC) such as natural killer (NK) cells and ILC 1-3s has become a focal point as several findings implicate them in the disease pathology. The role of ILCs in MS is still not completely understood as controversial findings have been reported assigning them either a protective or disease-accelerating role. Recent findings in experimental autoimmune encephalomyelitis (EAE) suggest that ILCs infiltrate the central nervous system (CNS), mediate inflammation, and have a disease exacerbating role by influencing the recruitment of autoreactive T-cells. Elucidating the detailed role of ILCs and altered signaling pathways in MS is essential for a more complete picture of the disease pathology and novel therapeutic targets. We here review the current knowledge about ILCs in the development and progression of MS and preclinical models of MS and discuss their potential for therapeutic applications. | - |
dc.description.sponsorship | NH and DG are supported by a grant from the Austrian Science Fund (FWF): ZK-81B. SM is supported by the JESH program of the Austrian Academy of Sciences. BB is supported by the Fonds voor Wetenschappelijk Onderzoek (FWO), the Belgian Charcot Foundation, Stichting MS Research, Multiple Sclerosis International Federation (MSIF) and MoveS. Wewant to thank our laboratorymembers and the entire Peptaides/ ZK-81B community as well as K. Klein for numerous discussions and to apologize to all investigators whose research was not cited. BioRender.com was used for all Figures. | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.rights | 2022 Sadeghi Hassanabadi, Broux, Marinovićand Gotthardt. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | - |
dc.subject.other | multiple sclerosis | - |
dc.subject.other | innate lymphoid cells (ILCs) | - |
dc.subject.other | natural killer cells | - |
dc.subject.other | experimental autoimmune encephalomyelitis (EAE) | - |
dc.subject.other | autoimmune disease | - |
dc.subject.other | disease-modifying therapies (DMTs) | - |
dc.title | Innate Lymphoid Cells-Neglected Players in Multiple Sclerosis | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 13 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Gotthardt, D (corresponding author), Univ Vet Med Vienna, Inst Pharmacol & Toxicol, Vienna, Austria. | - |
dc.description.notes | dagmar.gotthardt@vetmeduni.ac.at | - |
local.publisher.place | AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
local.bibliographicCitation.artnr | 909275 | - |
dc.identifier.doi | 10.3389/fimmu.2022.909275 | - |
dc.identifier.pmid | 35784374 | - |
dc.identifier.isi | 000820021800001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Hassanabadi, Negar Sadeghi; Gotthardt, Dagmar] Univ Vet Med Vienna, Inst Pharmacol & Toxicol, Vienna, Austria. | - |
local.description.affiliation | [Broux, Bieke] Univ MSCenter, Campus Diepenbeek, Diepenbeek, Belgium. | - |
local.description.affiliation | [Broux, Bieke] UHasselt, Biomed Res Inst, Dept Immunol & Infect, Neuro Immune Connect & Repair Lab, Diepenbeek, Belgium. | - |
local.description.affiliation | [Marinovic, Sonja] Rudjer Boskovic Inst, Div Mol Med, Lab Personalized Med, Zagreb, Croatia. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Hassanabadi, Negar Sadeghi; BROUX, Bieke; Marinovic, Sonja & Gotthardt, Dagmar (2022) Innate Lymphoid Cells-Neglected Players in Multiple Sclerosis. In: Frontiers in immunology, 13 (Art N° 909275). | - |
item.validation | ecoom 2023 | - |
item.contributor | Hassanabadi, Negar Sadeghi | - |
item.contributor | BROUX, Bieke | - |
item.contributor | Marinovic, Sonja | - |
item.contributor | Gotthardt, Dagmar | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 1664-3224 | - |
crisitem.journal.eissn | 1664-3224 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Innate Lymphoid Cells - Neglected Players in Multiple Sclerosis.pdf | Published version | 1.11 MB | Adobe PDF | View/Open |
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