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http://hdl.handle.net/1942/37866
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DC Field | Value | Language |
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dc.contributor.author | BELIEN, Hanne | - |
dc.contributor.author | EVENS, Lize | - |
dc.contributor.author | HENDRIKX, Marc | - |
dc.contributor.author | BITO, Virginie | - |
dc.contributor.author | BRONCKAERS, Annelies | - |
dc.date.accessioned | 2022-08-17T10:06:18Z | - |
dc.date.available | 2022-08-17T10:06:18Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-08-17T09:19:47Z | - |
dc.identifier.citation | Tissue Engineering Part A, 28 , p. S30 -S31 | - |
dc.identifier.issn | 2198-3844 | - |
dc.identifier.issn | 2198-3844 | - |
dc.identifier.uri | http://hdl.handle.net/1942/37866 | - |
dc.description.abstract | INTRODUCTION: Bone healing can be augmented by pre-conditioning MSCs (pMSCs) with inflammatory cytokines. Another approach is timely resolution of inflammation using immunomodula-tory cytokines. We investigated the efficacy of pMSC and genetically modified MSCs that over-express IL-4 (IL4-MSCs) on early stage steroid-associated osteonecrosis of the femoral head (ONFH) in rabbits .METHODS: 36 male mature NZW rabbits received methylpred-nisolone acetate (20mg/kgIM) 4 weeks before surgery. There were 6 groups: 1. Core Decompress (CD) alone-a 3 mm drill hole+ injection of:2. hydrogel (HG)-200 ml of hydrogel carrier3. MSCs-1 million rabbit MSCs4. pMSC-LPS (20 mg/ml) + TNFa (20 ng/ml) precondi-tioned MSCs 5. IL4-MSCs-rabbit IL-4 over-expressing MSCs 6. IL4-pMSCs-preconditioned IL-4 over-expressing MSCsEight weeks after surgery, femurs were evaluated by microCT, biomechanical, and his-tological analyses.RESULTS: Bone mineral density (BMD) and bone volume fraction (BVF) increased outside the CD in the pMSC group compared to the CD and MSC groups (p < 0.05). IL4-pMSC group was increased compared to the CD group (p < 0.05). The percentage of empty lacunae in the IL4-MSC group was significantly less than other groups outside the CD (p < 0.05); however, IL4-MSC group had less trabecular bone formation inside the CD. DISCUSSION: pMSC increased new bone formation after CD in ONFH; IL4-MSCs decreased the number of empty lacunae. Immunomodulation of bone healing has the potential to improve bone healing after CD for early stage ONFH; these interventions must be applied in a temporally sensitive fashion. | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject.other | Preconditioning | - |
dc.subject.other | Cardiac stem cells | - |
dc.subject.other | Dental pulp stem cells | - |
dc.title | THE BEST OF BOTH WORLDS: IN VITRO EVALUATION OF COMBINING TWO STEM CELL TYPES FOR TRUE CARDIAC REPAIR | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | S31 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | S30 | - |
dc.identifier.volume | 28 | - |
local.format.pages | 2 | - |
local.bibliographicCitation.jcat | M | - |
dc.description.notes | hanne.belien@uhasselt.be | - |
local.publisher.place | 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Meeting Abstract | - |
dc.identifier.doi | 10.1002/advs.202003332 | - |
dc.identifier.isi | 000821187300102 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Belien, Hanne; Evens, Lize; Bito, Virginie; Bronckaers, Annelies] Hasselt Univ, Biomed Res Inst BIOMED, Diepenbeek, Belgium. | - |
local.description.affiliation | [Hendrikx, Marc] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. | - |
local.uhasselt.international | no | - |
item.fullcitation | BELIEN, Hanne; EVENS, Lize; HENDRIKX, Marc; BITO, Virginie & BRONCKAERS, Annelies (2022) THE BEST OF BOTH WORLDS: IN VITRO EVALUATION OF COMBINING TWO STEM CELL TYPES FOR TRUE CARDIAC REPAIR. In: Tissue Engineering Part A, 28 , p. S30 -S31. | - |
item.contributor | BELIEN, Hanne | - |
item.contributor | EVENS, Lize | - |
item.contributor | HENDRIKX, Marc | - |
item.contributor | BITO, Virginie | - |
item.contributor | BRONCKAERS, Annelies | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1937-3341 | - |
crisitem.journal.eissn | 1937-335X | - |
Appears in Collections: | Research publications |
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