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http://hdl.handle.net/1942/37892
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DC Field | Value | Language |
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dc.contributor.author | Abdelhamid, Magdy | - |
dc.contributor.author | Rosano, Giuseppe | - |
dc.contributor.author | Metra, Marco | - |
dc.contributor.author | Adamopoulos, Stamatis | - |
dc.contributor.author | Boehm, Michael | - |
dc.contributor.author | Chioncel, Ovidiu | - |
dc.contributor.author | Filippatos, Gerasimos | - |
dc.contributor.author | Jankowska, Ewa A. | - |
dc.contributor.author | Lopatin, Yury | - |
dc.contributor.author | Lund, Lars | - |
dc.contributor.author | Milicic, Davor | - |
dc.contributor.author | Moura, Brenda | - |
dc.contributor.author | Ben Gal, Tuvia | - |
dc.contributor.author | Ristic, Arsen | - |
dc.contributor.author | Rakisheva, Amina | - |
dc.contributor.author | Savarese, Gianluigi | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.contributor.author | Piepoli, Massimo | - |
dc.contributor.author | Bayes-Genis, Antoni | - |
dc.contributor.author | Thum, Thomas | - |
dc.contributor.author | Anker, Stefan D. | - |
dc.contributor.author | Seferovic, Petar | - |
dc.contributor.author | Coats, Andrew J. S. | - |
dc.date.accessioned | 2022-08-18T08:55:58Z | - |
dc.date.available | 2022-08-18T08:55:58Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-08-16T11:11:50Z | - |
dc.identifier.citation | European journal of heart failure, 24 (9) , p. 1460-1466 | - |
dc.identifier.issn | 1388-9842 | - |
dc.identifier.uri | http://hdl.handle.net/1942/37892 | - |
dc.description.abstract | Sudden death is a devastating complication of heart failure (HF). Current guidelines recommend an implantable cardioverter-defibrillator (ICD) for prevention of sudden death in patients with HF and reduced ejection fraction (HFrEF) specifically those with a left ventricular ejection fraction <= 35% after at least 3 months of optimized HF treatment. The benefit of ICD in patients with symptomatic HFrEF caused by coronary artery disease has been well documented; however, the evidence for a benefit of prophylactic ICD implantation in patients with HFrEF of non-ischaemic aetiology is less strong. Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, beta-blockers (BB), and mineralocorticoid receptor antagonists (MRA) block the deleterious actions of angiotensin II, norepinephrine, and aldosterone, respectively. Neprilysin inhibition potentiates the actions of endogenous natriuretic peptides that mitigate adverse ventricular remodelling. BB, MRA, angiotensin receptor-neprilysin inhibitor (ARNI) have a favourable effect on reduction of sudden cardiac death in HFrEF. Recent data suggest a beneficial effect of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in reducing serious ventricular arrhythmias and sudden cardiac death in patients with HFrEF. So, in the current era of new drugs for HFrEF and with the optimal use of disease-modifying therapies (BB, MRA, ARNI and SGLT2i), we might need to reconsider the need and timing for use of ICD as primary prevention of sudden death, especially in HF of non-ischaemic aetiology. | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2022 European Society of Cardiology | - |
dc.subject.other | Heart failure with reduced ejection fraction | - |
dc.subject.other | Implantable cardioverter-defibrillator | - |
dc.subject.other | Sudden death | - |
dc.title | Prevention of sudden death in heart failure with reduced ejection fraction: do we still need an implantable cardioverter-defibrillator for primary prevention? | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1466 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 1460 | - |
dc.identifier.volume | 24 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Abdelhamid, M (corresponding author), Cairo Univ, Fac Med, Cardiol Dept, Le Rois Villa 29, Cairo 11835, Egypt. | - |
dc.description.notes | magdyabdelhamid@hotmail.com | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1002/ejhf.2594 | - |
dc.identifier.pmid | 35753058 | - |
dc.identifier.isi | 000826090600001 | - |
dc.identifier.eissn | 1879-0844 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Abdelhamid, Magdy] Cairo Univ, Fac Med, Cardiol Dept, Le Rois Villa 29, Cairo 11835, Egypt. | - |
local.description.affiliation | [Rosano, Giuseppe] Univ London, St Georges Hosp, NHS Trust, London, England. | - |
local.description.affiliation | [Metra, Marco] Univ Brescia, Inst Cardiol, ASST Spedali Civili Brescia, Brescia, Italy. | - |
local.description.affiliation | [Metra, Marco] Univ Brescia, Dept Med & Surg Specialties, Radiol Sci & Publ Hlth, Brescia, Italy. | - |
local.description.affiliation | [Adamopoulos, Stamatis] Onassis Cardiac Surg Ctr, Heart Failure Transplant Mech Circulatory Support, Athens, Greece. | - |
local.description.affiliation | [Boehm, Michael] Saarland Univ, Univ Klinikum Saarlandes, Klin Innere Med 3, Kardiol Angiol & Internist Intens Med, Homburg, Germany. | - |
local.description.affiliation | [Chioncel, Ovidiu] Univ Med & Pharm Carol Davila, Emergency Inst Cardiovasc DiseasesProf CC Iliescu, Bucharest, Romania. | - |
local.description.affiliation | [Filippatos, Gerasimos] Natl & Kapodistrian Univ Athens, Univ Hosp Attikon, Sch Med, Athens, Greece. | - |
local.description.affiliation | [Jankowska, Ewa A.] Wroclaw Med Univ, Inst Heart Dis, Wroclaw, Poland. | - |
local.description.affiliation | [Lopatin, Yury] Volgograd State Med Univ, Reg Cardiol Ctr, Volgograd, Russia. | - |
local.description.affiliation | [Lund, Lars; Savarese, Gianluigi] Karolinska Inst, Dept Med, Stockholm, Sweden. | - |
local.description.affiliation | [Lund, Lars; Savarese, Gianluigi] Karolinska Univ Hosp, Heart & Vasc Theme, Stockholm, Sweden. | - |
local.description.affiliation | [Milicic, Davor] Univ Zagreb, Sch Med, Zagreb, Croatia. | - |
local.description.affiliation | [Moura, Brenda] Armed Forces Hosp, Porto, Portugal. | - |
local.description.affiliation | [Moura, Brenda] Univ Porto, Fac Med, Porto, Portugal. | - |
local.description.affiliation | [Ben Gal, Tuvia] Rabin Med Ctr, Dept Cardiol, Petah Tiqwa, Israel. | - |
local.description.affiliation | [Ben Gal, Tuvia] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel. | - |
local.description.affiliation | [Ristic, Arsen] Univ Belgrade, Univ Clin Ctr Serbia, Dept Cardiol, Sch Med, Belgrade, Serbia. | - |
local.description.affiliation | [Rakisheva, Amina] Sci Res Inst Cardiol & Internal Med, Alma Ata, Kazakhstan. | - |
local.description.affiliation | [Mullens, Wilfried] Hasselt Univ, Cardiovasc Physiol, Hasselt, Belgium. | - |
local.description.affiliation | [Mullens, Wilfried] Ziekenhuis Oost Limburg, Genk, Belgium. | - |
local.description.affiliation | [Piepoli, Massimo] Univ Parma, Guglielmo de Saliceto Hosp, Cardiac Unit, Piacenza, Italy. | - |
local.description.affiliation | [Bayes-Genis, Antoni] Hosp Badalona Germans Trias & Pujol, Heart Inst, Badalona, Spain. | - |
local.description.affiliation | [Bayes-Genis, Antoni] Inst Salud Carlos III, CIBERCV, Madrid, Spain. | - |
local.description.affiliation | [Thum, Thomas] Hannover & Fraunhofer Inst Toxicol & Expt Med, Inst Mol & Therapeut Strategies, Hannover, Germany. | - |
local.description.affiliation | [Anker, Stefan D.] Charite, Dept Cardiol CVK, Berlin, Germany. | - |
local.description.affiliation | [Anker, Stefan D.] Charite, Berlin Inst Hlth Ctr Regenerat Therapies BCRT, German Ctr Cardiovasc Res DZHK, Partner Site Berlin, Berlin, Germany. | - |
local.description.affiliation | [Seferovic, Petar] Univ Belgrade, Dept Fac Med, Belgrade, Serbia. | - |
local.description.affiliation | [Seferovic, Petar] Serbian Acad Arts & Sci, Belgrade, Serbia. | - |
local.description.affiliation | [Coats, Andrew J. S.] Univ Warwick, Coventry, W Midlands, England. | - |
local.uhasselt.international | yes | - |
item.contributor | Abdelhamid, Magdy | - |
item.contributor | Rosano, Giuseppe | - |
item.contributor | Metra, Marco | - |
item.contributor | Adamopoulos, Stamatis | - |
item.contributor | Boehm, Michael | - |
item.contributor | Chioncel, Ovidiu | - |
item.contributor | Filippatos, Gerasimos | - |
item.contributor | Jankowska, Ewa A. | - |
item.contributor | Lopatin, Yury | - |
item.contributor | Lund, Lars | - |
item.contributor | Milicic, Davor | - |
item.contributor | Moura, Brenda | - |
item.contributor | Ben Gal, Tuvia | - |
item.contributor | Ristic, Arsen | - |
item.contributor | Rakisheva, Amina | - |
item.contributor | Savarese, Gianluigi | - |
item.contributor | MULLENS, Wilfried | - |
item.contributor | Piepoli, Massimo | - |
item.contributor | Bayes-Genis, Antoni | - |
item.contributor | Thum, Thomas | - |
item.contributor | Anker, Stefan D. | - |
item.contributor | Seferovic, Petar | - |
item.contributor | Coats, Andrew J. S. | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2023 | - |
item.fullcitation | Abdelhamid, Magdy; Rosano, Giuseppe; Metra, Marco; Adamopoulos, Stamatis; Boehm, Michael; Chioncel, Ovidiu; Filippatos, Gerasimos; Jankowska, Ewa A.; Lopatin, Yury; Lund, Lars; Milicic, Davor; Moura, Brenda; Ben Gal, Tuvia; Ristic, Arsen; Rakisheva, Amina; Savarese, Gianluigi; MULLENS, Wilfried; Piepoli, Massimo; Bayes-Genis, Antoni; Thum, Thomas; Anker, Stefan D.; Seferovic, Petar & Coats, Andrew J. S. (2022) Prevention of sudden death in heart failure with reduced ejection fraction: do we still need an implantable cardioverter-defibrillator for primary prevention?. In: European journal of heart failure, 24 (9) , p. 1460-1466. | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 1388-9842 | - |
crisitem.journal.eissn | 1879-0844 | - |
Appears in Collections: | Research publications |
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Prevention of sudden death in heart failure with reduced ejection fraction_ do we still needĀ an implantable cardioverterādefibrillator for primary prevention_.pdf Restricted Access | Published version | 551.48 kB | Adobe PDF | View/Open Request a copy |
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