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Title: | Prognostic value of left atrial volume index in degenerative mitral stenosis | Authors: | Yedidya, Idit Butcher, Steele C. STASSEN, Jan van der Bijl, Pieter Ngiam, Jinghao Nicholas Chew, Nicholas W. S. Sia, Ching-Hui Leow, Ryan Li, Tony Yi-Wei Kong, William K. F. Poh, Kian Keong Kornowski, Ran Marsan, Nina Ajmone Delgado, Victoria Bax, Jeroen J. |
Issue Date: | 2022 | Publisher: | SPRINGER | Source: | The international journal of cardiovascular imaging, 38 (12) , p. 2687-2693 | Abstract: | Purpose Degenerative mitral stenosis (DMS) is associated with a poor prognosis. Although mean transmitral gradient (TMG) has shown a good correlation with outcome, little is known about the association between other echocardiographic parameters and prognosis in patients with DMS. The current study aimed to evaluate the prognostic value of left atrial volume index (LAVI) in patients with DMS. Methods A total of 155 patients with DMS (72[63-80] years, 67% female) were included. The population was divided according to LAVI: normal-sized LAVI (LAVI <= 34 ml/m2); and enlarged LAVI (> 34 ml/m2). Results Patients with enlarged LAVI had a higher left ventricular mass index (120[96-146] vs. 91[70-112] g/m2 p < 0.001), as well as a higher prevalence of significant mitral regurgitation and severe aortic stenosis (23% vs. 10% p = 0.046 and 38% vs. 15% p=0.001, respectively) compared to patients with normal-sized LAVI. During a median follow-up of 25 months, 56 (36%) patients died. Patients with enlarged LAVI had worse prognosis compared to patients with normal-sized LAVI (p = 0.026). In multivariable Cox regression model, an enlarged LAVI was independently associated with all-cause mortality (HR 2.009, 95% CI 1.040 to 3.880, P = 0.038). Conclusion An enlarged LAVI (> 34 ml/m2) is significantly associated with excess mortality in patients with DMS. After adjusting for potential confounders, an enlarged LAVI was the only parameter that remained independently associated with prognosis. | Notes: | Bax, JJ (corresponding author), Leiden Univ Med Ctr, Dept Cardiol, Albinusdreef 2, NL-2300 RC Leiden, Netherlands.; Bax, JJ (corresponding author), Univ Turku, Turku PET Ctr, Turku, Finland.; Bax, JJ (corresponding author), Turku Univ Hosp, Turku, Finland. j.j.bax@lumc.nl |
Keywords: | Degenerative mitral stenosis;Prognosis;Left atrial volume index | Document URI: | http://hdl.handle.net/1942/37948 | ISSN: | 1569-5794 | e-ISSN: | 1875-8312 | DOI: | 10.1007/s10554-022-02691-z | ISI #: | 000826857200001 | Rights: | The Author(s) 2022 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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