Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/37956
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dc.contributor.authorPrior, Robert-
dc.contributor.authorSilva , Alessio-
dc.contributor.authorVANGANSEWINKEL, Tim-
dc.contributor.authorTharkeshwar, Arun-
dc.contributor.authorMichailidou, Iliana-
dc.contributor.authorVreijling, Jeroen-
dc.contributor.authorLoos, Maarten-
dc.contributor.authorKoopmans, Bastijn-
dc.contributor.authorVlek, Nina-
dc.contributor.authorStraat, Nina-
dc.contributor.authorAgaser, Cedrick-
dc.contributor.authorKuipers , Tom-
dc.contributor.authorRossaert, Elisabeth-
dc.contributor.authorVerschoren, Stijn-
dc.contributor.authorVermeire, Wendy-
dc.contributor.authorMichiels, Christine-
dc.contributor.authorDe Laat, Vincent-
dc.contributor.authorDehairs, Jonas-
dc.contributor.authorEggermont, Kristel-
dc.contributor.authorVan Den Biggelaar, Diede-
dc.contributor.authorVerfaillie, Catherine-
dc.contributor.authorVan Damme , Philip-
dc.contributor.authorMei, Hailiang (Leon)-
dc.contributor.authorSwinnen , Johan-
dc.contributor.authorWOLFS, Esther-
dc.contributor.authorBaas, Frank-
dc.contributor.authorFluiter, Kees-
dc.contributor.authorVan Den Bosch , Ludo-
dc.date.accessioned2022-09-01T13:58:37Z-
dc.date.available2022-09-01T13:58:37Z-
dc.date.issued2022-
dc.date.submitted2022-08-16T11:32:49Z-
dc.identifier.citationJOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 27 , p. S108-
dc.identifier.urihttp://hdl.handle.net/1942/37956-
dc.description.abstractIntro (50 words) Duplication of the peripheral myelin protein 22 (PMP22) causes Charcot-Marie-Tooth disease 1A (CMT1A) and is known to dysregulate lipid metabolism. However, a lack knowledge persists in the underlying mechanisms that lead to lipid metabolic defects that ultimately give rise to the CMT1A phenotype. Methods (50 words) We performed bulk RNA-sequencing on sciatic nerves of the C3 and C22 CMT1A mouse models (3-12 weeks of age) and on CMT1A patient derived Schwann cell precursors differentiated from induced pluripotent stem cells (iPS-SCPs). LC-MS/MS lipidomic analysis was also performed on 5-week-old C3 mice and on CMT1A iPS-SCPs. The lipidomic phenotypes were further analysed via electron microscopy, flow cytometry, high-content confocal immunofluorescence imaging and western blot. Results (100 words +-)-
dc.language.isoen-
dc.publisherWILEY-
dc.subject.otherCMT1A-
dc.subject.otherinherited neuropathies-
dc.subject.otherlipid metabolism-
dc.subject.otherPMP22-
dc.subject.otherSchwann cells-
dc.titlePMP22 OVEREXPRESSION CAUSES LIPID RECYCLING DEFECTS THAT ALTERS THE PLASMA MEMBRANE IN CMT1A-
dc.typeJournal Contribution-
dc.identifier.spageS108-
dc.identifier.volume27-
local.format.pages1-
local.bibliographicCitation.jcatM-
local.publisher.place111 RIVER ST, HOBOKEN 07030-5774, NJ USA-
local.type.refereedRefereed-
local.type.specifiedMeeting Abstract-
dc.identifier.isi000822950200221-
local.provider.typewosris-
local.description.affiliation[Prior, Robert; Silva, Alessio; Tharkeshwar, Arun; Rossaert, Elisabeth; Verschoren, Stijn; Michiels, Christine; Eggermont, Kristel; Van Den Biggelaar, Diede; Van Damme, Philip; Van Den Bosch, Ludo] VIB KU Leuven, Leuven, Belgium.-
local.description.affiliation[Vangansewinkel, Tim; Wolfs, Esther] UHasselt, Hasselt, Belgium.-
local.description.affiliation[Michailidou, Iliana; Vreijling, Jeroen; Baas, Frank; Fluiter, Kees] LUMC, Dept Clin Genet, Leiden, Netherlands.-
local.description.affiliation[Loos, Maarten; Koopmans, Bastijn; Vlek, Nina; Straat, Nina] Sylics Synaptol BV, Amsterdam, Netherlands.-
local.description.affiliation[Agaser, Cedrick; Kuipers, Tom; Mei, Hailiang (Leon)] LUMC, Dept Biomed Sci, Leiden, Netherlands.-
local.description.affiliation[Vermeire, Wendy] Augustine Therapeut, Leuven, Belgium.-
local.description.affiliation[De Laat, Vincent; Dehairs, Jonas; Verfaillie, Catherine; Swinnen, Johan] Katholieke Univ Leuven, Leuven, Belgium.-
local.uhasselt.internationalyes-
item.accessRightsRestricted Access-
item.fullcitationPrior, Robert; Silva , Alessio; VANGANSEWINKEL, Tim; Tharkeshwar, Arun; Michailidou, Iliana; Vreijling, Jeroen; Loos, Maarten; Koopmans, Bastijn; Vlek, Nina; Straat, Nina; Agaser, Cedrick; Kuipers , Tom; Rossaert, Elisabeth; Verschoren, Stijn; Vermeire, Wendy; Michiels, Christine; De Laat, Vincent; Dehairs, Jonas; Eggermont, Kristel; Van Den Biggelaar, Diede; Verfaillie, Catherine; Van Damme , Philip; Mei, Hailiang (Leon); Swinnen , Johan; WOLFS, Esther; Baas, Frank; Fluiter, Kees & Van Den Bosch , Ludo (2022) PMP22 OVEREXPRESSION CAUSES LIPID RECYCLING DEFECTS THAT ALTERS THE PLASMA MEMBRANE IN CMT1A. In: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 27 , p. S108.-
item.fulltextWith Fulltext-
item.contributorPrior, Robert-
item.contributorSilva , Alessio-
item.contributorVANGANSEWINKEL, Tim-
item.contributorTharkeshwar, Arun-
item.contributorMichailidou, Iliana-
item.contributorVreijling, Jeroen-
item.contributorLoos, Maarten-
item.contributorKoopmans, Bastijn-
item.contributorVlek, Nina-
item.contributorStraat, Nina-
item.contributorAgaser, Cedrick-
item.contributorKuipers , Tom-
item.contributorRossaert, Elisabeth-
item.contributorVerschoren, Stijn-
item.contributorVermeire, Wendy-
item.contributorMichiels, Christine-
item.contributorDe Laat, Vincent-
item.contributorDehairs, Jonas-
item.contributorEggermont, Kristel-
item.contributorVan Den Biggelaar, Diede-
item.contributorVerfaillie, Catherine-
item.contributorVan Damme , Philip-
item.contributorMei, Hailiang (Leon)-
item.contributorSwinnen , Johan-
item.contributorWOLFS, Esther-
item.contributorBaas, Frank-
item.contributorFluiter, Kees-
item.contributorVan Den Bosch , Ludo-
crisitem.journal.issn1085-9489-
crisitem.journal.eissn1529-8027-
Appears in Collections:Research publications
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