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http://hdl.handle.net/1942/37977
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DC Field | Value | Language |
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dc.contributor.author | MULLENS, Wilfried | - |
dc.contributor.author | DAUW, Jeroen | - |
dc.contributor.author | Martens, Pieter | - |
dc.contributor.author | MEEKERS, Evelyne | - |
dc.contributor.author | NIJST, Petra | - |
dc.contributor.author | VERBRUGGE, Frederik | - |
dc.contributor.author | Chenot, Fabien | - |
dc.contributor.author | Moubayed, Samer | - |
dc.contributor.author | Dierckx , Riet | - |
dc.contributor.author | Blouard, Philippe | - |
dc.contributor.author | Derthoo, David | - |
dc.contributor.author | Smolders, Walter | - |
dc.contributor.author | Ector , Bavo | - |
dc.contributor.author | Hulselmans, Michael | - |
dc.contributor.author | Lochy, Stijn | - |
dc.contributor.author | Raes , David | - |
dc.contributor.author | Van Craenenbroeck, Emeline | - |
dc.contributor.author | Vandekerckhove, Hans | - |
dc.contributor.author | Hofkens, Pieter-Jan | - |
dc.contributor.author | Goossens, Kathleen | - |
dc.contributor.author | Pouleur, Anne-Catherine | - |
dc.contributor.author | De Ceuninck, Michel | - |
dc.contributor.author | Gabriel, Laurence | - |
dc.contributor.author | Timmermans, Philippe | - |
dc.contributor.author | Prihadi, Edgard A. | - |
dc.contributor.author | Van Durme, Frederik | - |
dc.contributor.author | Depauw, Michel | - |
dc.contributor.author | Vervloet, Delphine | - |
dc.contributor.author | Viaene, Els | - |
dc.contributor.author | Vachiery, Jean-Luc | - |
dc.contributor.author | Tartaglia, Katrien | - |
dc.contributor.author | Ter Maaten, Jozine M. | - |
dc.contributor.author | BRUCKERS, Liesbeth | - |
dc.contributor.author | Droogne, Walter | - |
dc.contributor.author | Troisfontaines, Pierre | - |
dc.contributor.author | Damman, Kevin | - |
dc.contributor.author | Lassus, Johan | - |
dc.contributor.author | Mebazaa, Alexandre | - |
dc.contributor.author | Filippatos, Gerasimos | - |
dc.contributor.author | Ruschitzka, Frank | - |
dc.contributor.author | DUPONT, Matthias | - |
dc.date.accessioned | 2022-09-05T12:15:09Z | - |
dc.date.available | 2022-09-05T12:15:09Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-08-16T12:59:55Z | - |
dc.identifier.citation | European journal of heart failure, | - |
dc.identifier.uri | http://hdl.handle.net/1942/37977 | - |
dc.description.abstract | Aims To describe the baseline characteristics of participants in the Acetazolamide in Decompensated Heart Failure with Volume Overload (ADVOR) trial and compare these with other contemporary diuretic trials in acute heart failure (AHF). Methods and results ADVOR recruited 519 patients with AHF, clinically evident volume overload, elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) and maintenance loop diuretic therapy prior to admission. All participants received standardized loop diuretics and were randomized towards once daily intravenous acetazolamide (500 mg) versus placebo, stratified according to study centre and left ventricular ejection fraction (LVEF) (<= 40% vs. >40%). The primary endpoint was successful decongestion assessed by a dedicated score indicating no more than trace oedema and no other signs of congestion after three consecutive days of treatment without need for escalating treatment. Mean age was 78 years, 63% were men, mean LVEF was 43%, and median NT-proBNP 6173 pg/ml. The median clinical congestion score was 4 with an EuroQol-5 dimensions health utility index of 0.6. Patients with LVEF <= 40% were more often male, had more ischaemic heart disease, higher levels of NT-proBNP and less atrial fibrillation. Compared with diuretic trials in AHF, patients enrolled in ADVOR were considerably older with higher NT-proBNP levels, reflecting the real-world clinical situation. Conclusion ADVOR is the largest randomized diuretic trial in AHF, investigating acetazolamide to improve decongestion on top of standardized loop diuretics. The elderly enrolled population with poor quality of life provides a good representation of the real-world AHF population. The pragmatic design will provide novel insights in the diuretic treatment of patients with AHF. | - |
dc.description.sponsorship | This study (KCE-17001) is an independent research funded by Belgian Health Care Knowledge Centre under the KCE Trials Programme. The views expressed in this publication are those of the author and not necessarily those of Belgian Health Care Knowledge Centre. Belgian Health Care Knowledge Centre as independent reviewer of the study protocol. | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2022 European Society of Cardiology | - |
dc.subject.other | Acute heart failure | - |
dc.subject.other | Belgium | - |
dc.subject.other | Diuretics | - |
dc.subject.other | 5 Grand Hôpital de Charleroi, Charleroi, Belgium | - |
dc.subject.other | Randomized controlled trial | - |
dc.subject.other | 6 CHU Charleroi, Charleroi, Belgium | - |
dc.subject.other | 7 OLV Hospital, Aalst, Belgium | - |
dc.subject.other | Acetazolamide | - |
dc.subject.other | Congestion | - |
dc.subject.other | 8 Clinic Saint-Luc, Bouge, Belgium | - |
dc.subject.other | Volume overload | - |
dc.subject.other | 9 AZ Groeninge, Kortrijk, Belgium | - |
dc.subject.other | 10 AZ Klina, Brasschaat, Belgium | - |
dc.subject.other | 11 Imelda Hospital, Bonheiden, Belgium | - |
dc.subject.other | 12 Ziekenhuis Maas en Kempen, Maaseik, Belgium | - |
dc.subject.other | 13 GZA Sint-Augustinus, Wilrijk, Belgium | - |
dc.subject.other | 14 Belgium | - |
dc.subject.other | 16 AZ Sint-Lucas, Ghent, Belgium | - |
dc.subject.other | 17 AZ Turnhout, Turnhout, Belgium | - |
dc.subject.other | 18 AZ Nikolaas, Sint-Niklaas, Belgium | - |
dc.subject.other | 19 Cardiovascular Department, Cliniques Universitaires St Luc, Brussels, Belgium | - |
dc.subject.other | 20 AZ Delta, Roeselare, Belgium | - |
dc.subject.other | 21 CHU UCL Namur, Yvoir, Belgium | - |
dc.subject.other | 22 Jessa Hospital, Hasselt, Belgium | - |
dc.subject.other | 23 ZNA Hartcentrum, Antwerpen, Belgium | - |
dc.subject.other | 24 AZ Glorieux, Ronse, Belgium | - |
dc.subject.other | 25 Universitair Ziekenhuis Gent, Ghent, Belgium | - |
dc.subject.other | 26 AZ Maria Middelares, Ghent, Belgium | - |
dc.subject.other | 27 Jan Yperman Hospital, Ieper, Belgium | - |
dc.subject.other | 28 Ziekenhuis Erasme, Brussels, Belgium | - |
dc.title | Acetazolamide in Decompensated Heart Failure with Volume Overload trial (ADVOR): baseline characteristics | - |
dc.type | Journal Contribution | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Mullens, W (corresponding author), Ziekenhuis Oost Limburg, Schiepse Bos 6, B-3600 Genk, Belgium. | - |
dc.description.notes | wilfried.mullens@zol.be | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | Early view | - |
dc.identifier.doi | 10.1002/ejhf.2587 | - |
dc.identifier.pmid | 35733283 | - |
dc.identifier.isi | 000822982700001 | - |
dc.contributor.orcid | Troisfontaines, Pierre/0000-0003-3528-3496; Verbrugge, Frederik | - |
dc.contributor.orcid | Hendrik/0000-0003-0599-9290 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Mullens, Wilfried; Dauw, Jeroen; Martens, Pieter; Meekers, Evelyne; Nijst, Petra; Tartaglia, Katrien; Dupont, Matthias] Ziekenhuis Oost Limburg, Schiepse Bos 6, B-3600 Genk, Belgium. | - |
local.description.affiliation | [Mullens, Wilfried; Dauw, Jeroen; Meekers, Evelyne; Bruckers, Liesbeth] Hasselt Univ, Diepenbeek, Belgium. | - |
local.description.affiliation | [Verbrugge, Frederik H.; Lochy, Stijn] Univ Ziekenhuis Brussel, Jette, Belgium. | - |
local.description.affiliation | [Verbrugge, Frederik H.] Vrije Univ Brussel, Jette, Belgium. | - |
local.description.affiliation | [Chenot, Fabien] Grand Hop Charleroi, Charleroi, Belgium. | - |
local.description.affiliation | [Moubayed, Samer] CHU Charleroi, Charleroi, Belgium. | - |
local.description.affiliation | [Dierckx, Riet] Onze Lieve Vrouw Hosp, Aalst, Belgium. | - |
local.description.affiliation | [Blouard, Philippe] Clin St Luc, Bouge, Belgium. | - |
local.description.affiliation | [Derthoo, David] AZ Groeninge, Kortrijk, Belgium. | - |
local.description.affiliation | [Smolders, Walter] AZ Klina, Brasschaat, Belgium. | - |
local.description.affiliation | [Ector, Bavo] Imelda Hosp, Bonheiden, Belgium. | - |
local.description.affiliation | [Hulselmans, Michael] Ziekenhuis Maas & Kempen, Maaseik, Belgium. | - |
local.description.affiliation | [Raes, David] GZA Sint Augustinus, Antwerp, Belgium. | - |
local.description.affiliation | [Van Craenenbroeck, Emeline] Antwerp Univ Hosp, Dept Cardiol, Edegem, Belgium. | - |
local.description.affiliation | [Van Craenenbroeck, Emeline] Univ Antwerp, GENCOR, Res Grp Cardiovasc Dis, Antwerp, Belgium. | - |
local.description.affiliation | [Vandekerckhove, Hans] AZ Sint Lucas, Ghent, Belgium. | - |
local.description.affiliation | [Hofkens, Pieter-Jan] AZ Turnhout, Turnhout, Belgium. | - |
local.description.affiliation | [Goossens, Kathleen] AZ Nikolaas, St Niklaas, Belgium. | - |
local.description.affiliation | [Pouleur, Anne-Catherine] Clin Univ St Luc, Cardiovasc Dept, Brussels, Belgium. | - |
local.description.affiliation | [De Ceuninck, Michel] AZ Delta, Roeselare, Belgium. | - |
local.description.affiliation | [Gabriel, Laurence] CHU UCL Namur, Yvoir, Belgium. | - |
local.description.affiliation | [Timmermans, Philippe] Jessa Hosp, Hasselt, Belgium. | - |
local.description.affiliation | [Prihadi, Edgard A.] ZNA Hartctr, Antwerp, Belgium. | - |
local.description.affiliation | [Van Durme, Frederik] AZ Glorieux, Ronse, Belgium. | - |
local.description.affiliation | [Depauw, Michel] Univ Ziekenhuis Gent, Ghent, Belgium. | - |
local.description.affiliation | [Vervloet, Delphine] AZ Maria Middelares, Ghent, Belgium. | - |
local.description.affiliation | [Viaene, Els] Jan Yperman Hosp, Ieper, Belgium. | - |
local.description.affiliation | [Vachiery, Jean-Luc] Ziekenhuis Erasme, Brussels, Belgium. | - |
local.description.affiliation | [Ter Maaten, Jozine M.; Damman, Kevin] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands. | - |
local.description.affiliation | [Droogne, Walter] Univ Hosp Leuven, Leuven, Belgium. | - |
local.description.affiliation | [Troisfontaines, Pierre] CHR Citadelle Hosp, Liege, Belgium. | - |
local.description.affiliation | [Lassus, Johan] Helsinki Univ Cent Hosp, Heart & Lung Ctr, Helsinki, Finland. | - |
local.description.affiliation | [Lassus, Johan] Helsinki Univ Hosp, Helsinki, Finland. | - |
local.description.affiliation | [Mebazaa, Alexandre] Univ Paris Cite, Paris, France. | - |
local.description.affiliation | [Filippatos, Gerasimos] Natl & Kapodistrian Univ Athens, Athens, Greece. | - |
local.description.affiliation | [Ruschitzka, Frank] Univ Spital Zurich, Zurich, Switzerland. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2023 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | MULLENS, Wilfried; DAUW, Jeroen; Martens, Pieter; MEEKERS, Evelyne; NIJST, Petra; VERBRUGGE, Frederik; Chenot, Fabien; Moubayed, Samer; Dierckx , Riet; Blouard, Philippe; Derthoo, David; Smolders, Walter; Ector , Bavo; Hulselmans, Michael; Lochy, Stijn; Raes , David; Van Craenenbroeck, Emeline; Vandekerckhove, Hans; Hofkens, Pieter-Jan; Goossens, Kathleen; Pouleur, Anne-Catherine; De Ceuninck, Michel; Gabriel, Laurence; Timmermans, Philippe; Prihadi, Edgard A.; Van Durme, Frederik; Depauw, Michel; Vervloet, Delphine; Viaene, Els; Vachiery, Jean-Luc; Tartaglia, Katrien; Ter Maaten, Jozine M.; BRUCKERS, Liesbeth; Droogne, Walter; Troisfontaines, Pierre; Damman, Kevin; Lassus, Johan; Mebazaa, Alexandre; Filippatos, Gerasimos; Ruschitzka, Frank & DUPONT, Matthias (2022) Acetazolamide in Decompensated Heart Failure with Volume Overload trial (ADVOR): baseline characteristics. In: European journal of heart failure,. | - |
item.accessRights | Restricted Access | - |
item.contributor | MULLENS, Wilfried | - |
item.contributor | DAUW, Jeroen | - |
item.contributor | Martens, Pieter | - |
item.contributor | MEEKERS, Evelyne | - |
item.contributor | NIJST, Petra | - |
item.contributor | VERBRUGGE, Frederik | - |
item.contributor | Chenot, Fabien | - |
item.contributor | Moubayed, Samer | - |
item.contributor | Dierckx , Riet | - |
item.contributor | Blouard, Philippe | - |
item.contributor | Derthoo, David | - |
item.contributor | Smolders, Walter | - |
item.contributor | Ector , Bavo | - |
item.contributor | Hulselmans, Michael | - |
item.contributor | Lochy, Stijn | - |
item.contributor | Raes , David | - |
item.contributor | Van Craenenbroeck, Emeline | - |
item.contributor | Vandekerckhove, Hans | - |
item.contributor | Hofkens, Pieter-Jan | - |
item.contributor | Goossens, Kathleen | - |
item.contributor | Pouleur, Anne-Catherine | - |
item.contributor | De Ceuninck, Michel | - |
item.contributor | Gabriel, Laurence | - |
item.contributor | Timmermans, Philippe | - |
item.contributor | Prihadi, Edgard A. | - |
item.contributor | Van Durme, Frederik | - |
item.contributor | Depauw, Michel | - |
item.contributor | Vervloet, Delphine | - |
item.contributor | Viaene, Els | - |
item.contributor | Vachiery, Jean-Luc | - |
item.contributor | Tartaglia, Katrien | - |
item.contributor | Ter Maaten, Jozine M. | - |
item.contributor | BRUCKERS, Liesbeth | - |
item.contributor | Droogne, Walter | - |
item.contributor | Troisfontaines, Pierre | - |
item.contributor | Damman, Kevin | - |
item.contributor | Lassus, Johan | - |
item.contributor | Mebazaa, Alexandre | - |
item.contributor | Filippatos, Gerasimos | - |
item.contributor | Ruschitzka, Frank | - |
item.contributor | DUPONT, Matthias | - |
crisitem.journal.issn | 1388-9842 | - |
crisitem.journal.eissn | 1879-0844 | - |
Appears in Collections: | Research publications |
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Acetazolamide in Decompensated Heart Failure with Volume Overload trial (ADVOR)_ baseline characteristics.pdf Restricted Access | Published version | 1.42 MB | Adobe PDF | View/Open Request a copy |
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