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http://hdl.handle.net/1942/37978
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DC Field | Value | Language |
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dc.contributor.author | Everaerts, Melissa | - |
dc.contributor.author | COOLS, Lennert | - |
dc.contributor.author | ADRIAENSENS, Peter | - |
dc.contributor.author | REEKMANS, Gunter | - |
dc.contributor.author | Baatsen, Pieter | - |
dc.contributor.author | Van den Mooter, Guy | - |
dc.date.accessioned | 2022-09-05T12:30:31Z | - |
dc.date.available | 2022-09-05T12:30:31Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-08-16T13:02:22Z | - |
dc.identifier.citation | Molecular pharmaceutics (Print), 19 (8) , p. 2712 -2724 | - |
dc.identifier.uri | http://hdl.handle.net/1942/37978 | - |
dc.description.abstract | In the present work, an insoluble polymer, i.e., ethyl cellulose (EC), was combined with the water-soluble polyvinylpyrrolidone (PVP) as a carrier system for the formulation of amorphous solid dispersions. The rationale was that by conjoining these two different types of carriers a more gradual drug release could be created with less risk for precipitation. Our initial hypothesis was that upon contact with the dissolution medium, PVP would be released, creating a porous EC matrix through which the model drug indomethacin could diffuse. On the basis of observations of EC as a coating material, the effect of the molecular weight of PVP, and the ratio of EC/PVP on the miscibility of the polymer blend, the solid state of the solid dispersion and the drug release from these solid dispersions were investigated. X-ray powder diffraction, modulated differential scanning calorimetry, and solid-state nuclear magnetic resonance were used to unravel the miscibility and solid-state properties of these blends and solid dispersions. Solid-state nuclear magnetic resonance appeared to be a crucial technique for this aspect as modulated differential scanning calorimetry was not sufficient to grasp the complex phase behavior of these systems. Both EC/PVP K12 and EC/PVP K25 blends were miscible over the entire composition range, and addition of indomethacin did not alter this. Concerning the drug release, it was initially thought that more PVP would lead to faster drug release with a higher probability that all of the drug molecules would be able to diffuse out of the EC network as more pores would be created. However, this view on the release mechanism appeared to be too simplistic as an optimum was observed for both blends. On the basis of this work, it could be concluded that drug release from this complex ternary system was affected not only by the ratio of EC/PVP and the molecular weight of PVP but also by interactions between the three components, the wettability of the formulations, and the viscosity layer that was created around the particles. | - |
dc.description.sponsorship | We thank Danny Winant from MTM (KU Leuven) for TGA analysis and Gunter Reekmans (Hasselt University) for performing the ssNMR experiments. We also acknowledge Timothy Pas for his help with the in vitro release experiments and Bernard Appeltans for technical support. | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.rights | 2022 American Chemical Society | - |
dc.subject.other | amorphous solid dispersion | - |
dc.subject.other | insoluble carrier | - |
dc.subject.other | ethyl cellulose | - |
dc.subject.other | porosity-increasing agent | - |
dc.subject.other | ternary solid dispersions | - |
dc.title | Investigating the Potential of Ethyl Cellulose and a Porosity- Increasing Agent as a Carrier System for the Formulation of Amorphous Solid Dispersions | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 2724 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 2712 | - |
dc.identifier.volume | 19 | - |
local.format.pages | 13 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | van den Mooter, G (corresponding author), Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Drug Delivery & Disposit, B-3000 Leuven, Belgium. | - |
dc.description.notes | guy.vandenmooter@kuleuven.be | - |
local.publisher.place | 1155 16TH ST, NW, WASHINGTON, DC 20036 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1021/acs.molpharmaceut.1c00972 | - |
dc.identifier.pmid | 35476407 | - |
dc.identifier.isi | 000823342000001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Everaerts, Melissa; Cools, Lennert; Van den Mooter, Guy] Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Drug Delivery & Disposit, B-3000 Leuven, Belgium. | - |
local.description.affiliation | [Adriaensens, Peter; Reekmans, Gunter] Hasselt Univ, Inst Mat Res, Appl & Analyt Chem, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Baatsen, Pieter] Katholieke Univ Leuven, Dept Neurosci, Electron Microscopy Platform & Bio Imaging Core, VIB KU Leuven Cente Brain & Dis Res, B-3000 Leuven, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | Everaerts, Melissa; COOLS, Lennert; ADRIAENSENS, Peter; REEKMANS, Gunter; Baatsen, Pieter & Van den Mooter, Guy (2022) Investigating the Potential of Ethyl Cellulose and a Porosity- Increasing Agent as a Carrier System for the Formulation of Amorphous Solid Dispersions. In: Molecular pharmaceutics (Print), 19 (8) , p. 2712 -2724. | - |
item.validation | ecoom 2023 | - |
item.contributor | Everaerts, Melissa | - |
item.contributor | COOLS, Lennert | - |
item.contributor | ADRIAENSENS, Peter | - |
item.contributor | REEKMANS, Gunter | - |
item.contributor | Baatsen, Pieter | - |
item.contributor | Van den Mooter, Guy | - |
crisitem.journal.issn | 1543-8384 | - |
crisitem.journal.eissn | 1543-8392 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Investigating the Potential of Ethyl Cellulose and a Porosity-Increasing Agent as a Carrier System for the Formulation of Amorphous Solid Dispersions.pdf Restricted Access | Published version | 14.9 MB | Adobe PDF | View/Open Request a copy |
Everaerts et al-MolPharm-Revised manuscript Final.docx.pdf | Peer-reviewed author version | 1.33 MB | Adobe PDF | View/Open |
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