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http://hdl.handle.net/1942/38013
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DC Field | Value | Language |
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dc.contributor.author | Nauwelaerts, Sarah J. D. | - |
dc.contributor.author | De Cremer, Koen | - |
dc.contributor.author | Bustos Sierra, Natalia | - |
dc.contributor.author | Gand, Mathieu | - |
dc.contributor.author | Van Geel , Dirk | - |
dc.contributor.author | Delvoye, Maud | - |
dc.contributor.author | Vandermassen, Els | - |
dc.contributor.author | Vercauteren, Jordy | - |
dc.contributor.author | Stroobants, Christophe | - |
dc.contributor.author | Bernard, Alfred | - |
dc.contributor.author | SAENEN, Nelly | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | Roosens, Nancy H. C. | - |
dc.contributor.author | De Keersmaecker, Sigrid C. J. | - |
dc.date.accessioned | 2022-09-08T09:07:04Z | - |
dc.date.available | 2022-09-08T09:07:04Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-08-17T10:51:26Z | - |
dc.identifier.citation | International journal of environmental research and public health (Print), 19 (14) (Art N° 8531) | - |
dc.identifier.uri | http://hdl.handle.net/1942/38013 | - |
dc.description.abstract | Air pollution exposure can lead to exacerbation of respiratory disorders in children. Using sensitive biomarkers helps to assess the impact of air pollution on children's respiratory health and combining protein, genetic and epigenetic biomarkers gives insights on their interrelatedness. Most studies do not contain such an integrated approach and investigate these biomarkers individually in blood, although its collection in children is challenging. Our study aimed at assessing the feasibility of conducting future integrated larger-scale studies evaluating respiratory health risks of air pollution episodes in children, based on a qualitative analysis of the technical and logistic aspects of a small-scale field study involving 42 children. This included the preparation, collection and storage of non-invasive samples (urine, saliva), the measurement of general and respiratory health parameters and the measurement of specific biomarkers (genetic, protein, epigenetic) of respiratory health and air pollution exposure. Bottlenecks were identified and modifications were proposed to expand this integrated study to a higher number of children, time points and locations. This would allow for non-invasive assessment of the impact of air pollution exposure on the respiratory health of children in future larger-scale studies, which is critical for the development of policies or measures at the population level. | - |
dc.description.sponsorship | This study was funded by the Belgian Federal Science Policy Office (BELSPO) and Sciensano who funded this research through the project PMOLLUGENIX-V2 (BELSPO, BR/165/PI/ PMOLLUGENIX) and the research project Respikid (Sciensano PJ/RP), respectively. The authors would like to thank the Belgian Federal Science Policy Office (BELSPO) and Sciensano who funded this research through the project PMOLLUGENIX-V2 (BELSPO, BR/165/PI/ PMOLLUGENIX) and the research project Respikid (Sciensano PJ/RP), respectively. We would also like to thank Irceline and Leefmilieu Brussel-BIM (Het Brussels Instituut voor Milieubeheer) for making pollutant data available. Finally, they would like to thank all the participating Belgian schools and the associated CLBs for their enthusiastic collaboration during the field study | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | - |
dc.subject.other | biomarkers | - |
dc.subject.other | epidemiological studies | - |
dc.subject.other | non-invasive | - |
dc.subject.other | children | - |
dc.subject.other | feasibility | - |
dc.subject.other | air pollution | - |
dc.subject.other | particulate matter | - |
dc.subject.other | ozone | - |
dc.title | Assessment of the Feasibility of a Future Integrated Larger-Scale Epidemiological Study to Evaluate Health Risks of Air Pollution Episodes in Children | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 14 | - |
dc.identifier.volume | 19 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | De Keersmaecker, SCJ (corresponding author), Sciensano, Transversal Act Appl Genom, B-1050 Brussels, Belgium. | - |
dc.description.notes | sarah.nauwelaerts@sciensano.be; koen.decremer@sciensano.be; | - |
dc.description.notes | natalia.bustossierra@sciensano.be; mathieu.gand@sciensano.be; | - |
dc.description.notes | dirk.vangeel@sciensano.be; maud.delvoye@sciensano.be; | - |
dc.description.notes | els.vandermassen@sciensano.be; j.vercauteren@vmm.be; | - |
dc.description.notes | c.stroobants@vmm.be; alfred.bernard@uclouvain.be; | - |
dc.description.notes | nelly.saenen@uhasselt.be; tim.nawrot@uhasselt.be; | - |
dc.description.notes | nancy.roosens@sciensano.be; sigrid.dekeersmaecker@sciensano.be | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 8531 | - |
dc.identifier.doi | 10.3390/ijerph19148531 | - |
dc.identifier.pmid | 35886381 | - |
dc.identifier.isi | 000831681400001 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Nauwelaerts, Sarah J. D.; Gand, Mathieu; Van Geel, Dirk; Delvoye, Maud; Vandermassen, Els; Roosens, Nancy H. C.; De Keersmaecker, Sigrid C. J.] Sciensano, Transversal Act Appl Genom, B-1050 Brussels, Belgium. | - |
local.description.affiliation | [Nauwelaerts, Sarah J. D.; Bernard, Alfred] Catholic Univ Louvain, Ctr Toxicol & Appl Pharmacol, B-1200 Brussels, Belgium. | - |
local.description.affiliation | [De Cremer, Koen] Sciensano, Platform Chromatog & Mass Spectrometry, B-1050 Brussels, Belgium. | - |
local.description.affiliation | [Bustos Sierra, Natalia] Sciensano, Epidemiol & Publ Hlth, B-1050 Brussels, Belgium. | - |
local.description.affiliation | [Vercauteren, Jordy; Stroobants, Christophe] Vlaamse Milieumaatschappij, Unit Air, B-2000 Antwerp, Belgium. | - |
local.description.affiliation | [Saenen, Nelly D.; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Nawrot, Tim S.] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, B-3000 Leuven, Belgium. | - |
local.uhasselt.international | no | - |
item.contributor | Nauwelaerts, Sarah J. D. | - |
item.contributor | De Cremer, Koen | - |
item.contributor | Bustos Sierra, Natalia | - |
item.contributor | Gand, Mathieu | - |
item.contributor | Van Geel , Dirk | - |
item.contributor | Delvoye, Maud | - |
item.contributor | Vandermassen, Els | - |
item.contributor | Vercauteren, Jordy | - |
item.contributor | Stroobants, Christophe | - |
item.contributor | Bernard, Alfred | - |
item.contributor | SAENEN, Nelly | - |
item.contributor | NAWROT, Tim | - |
item.contributor | Roosens, Nancy H. C. | - |
item.contributor | De Keersmaecker, Sigrid C. J. | - |
item.validation | ecoom 2023 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | Nauwelaerts, Sarah J. D.; De Cremer, Koen; Bustos Sierra, Natalia; Gand, Mathieu; Van Geel , Dirk; Delvoye, Maud; Vandermassen, Els; Vercauteren, Jordy; Stroobants, Christophe; Bernard, Alfred; SAENEN, Nelly; NAWROT, Tim; Roosens, Nancy H. C. & De Keersmaecker, Sigrid C. J. (2022) Assessment of the Feasibility of a Future Integrated Larger-Scale Epidemiological Study to Evaluate Health Risks of Air Pollution Episodes in Children. In: International journal of environmental research and public health (Print), 19 (14) (Art N° 8531). | - |
crisitem.journal.issn | 1661-7827 | - |
crisitem.journal.eissn | 1660-4601 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Assessment of the Feasibility of a Future Integrated Larger-Scale Epidemiological Study to Evaluate Health Risks of Air Pollution Episodes in Children.pdf | Published version | 744.22 kB | Adobe PDF | View/Open |
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