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http://hdl.handle.net/1942/38029
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DC Field | Value | Language |
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dc.contributor.author | Wijtvliet, Veerle P. W. M. | - |
dc.contributor.author | Verheyden, Sonja | - |
dc.contributor.author | Depreter, Barbara | - |
dc.contributor.author | Heylen, Christine | - |
dc.contributor.author | Coeman, Elke | - |
dc.contributor.author | ABRAMS, Steven | - |
dc.contributor.author | De Winter, Benedicte Y. | - |
dc.contributor.author | Massart, Annick | - |
dc.contributor.author | Hellemans , Rachel | - |
dc.contributor.author | Pipeleers, Lissa | - |
dc.contributor.author | Claas, Frans H. J. | - |
dc.contributor.author | Arien, Kevin K. | - |
dc.contributor.author | Wissing, Karl Martin | - |
dc.contributor.author | Abramowicz, Daniel | - |
dc.contributor.author | Ledeganck, Kristien J. | - |
dc.date.accessioned | 2022-09-08T14:23:16Z | - |
dc.date.available | 2022-09-08T14:23:16Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-08-18T11:24:37Z | - |
dc.identifier.citation | TRANSPLANT IMMUNOLOGY, 74 (Art N° 101670) | - |
dc.identifier.uri | http://hdl.handle.net/1942/38029 | - |
dc.description.abstract | Background: SARS-CoV-2 vaccination is strongly recommended in kidney transplant recipients (KTR) and dialysis patients. Whether these vaccinations may trigger alloantibodies, is still debated. Methods: In the current study we evaluated the effect of SARS-CoV-2 mRNA vaccines on anti-Human Leukocyte Antigen (HLA) and 60 anti-non-HLA antibody profiles in clinically stable KTR and dialysis patients. In total, we included 28 KTR, 30 patients on haemodialysis, 25 patients on peritoneal dialysis and 31 controls with a positive seroresponse 16-21 days after the first dose of either the SARS-CoV-2 mRNA BNT162b2 or mRNA-1273 vaccine. Both anti-HLA and anti-non-HLA antibodies were determined prior to vaccination and 21 to 35 days after the second vaccine dose. Results: Overall, the proportion of patients with detectable anti-HLA antibodies was similar before and after vaccination (class I 14% vs. 16%, p = 0.48; class II 25% before and after vaccination). After vaccination, there was no pattern in 1) additionally detected anti-HLA antibodies, or 2) the levels of pre-existing ones. Additional anti-non-HLA antibodies were detected in 30% of the patients, ranging from 1 to 5 new anti-non-HLA antibodies per patient. However, the clinical significance of anti-non-HLA antibodies is still a matter of debate. To date, only a significant association has been found for anti-non-HLA ARHGDIB antibodies and long-term kidney graft loss. No additionally developed anti-ARHGDIB antibodies or elevated level of existing anti-ARHGDIB antibodies was observed. Conclusion: The current data indicate that SARS-CoV-2 mRNA vaccination does not induce anti-HLA or anti-non-HLA antibodies, corroborating the importance of vaccinating KTR and dialysis patients. | - |
dc.description.sponsorship | The authors received no specific funding for this work The authors would like to thank the study nurses E. Meersman, S. Verhofstede, N. Marmitte and T. Bogaerts for their excellent and efficient help. We also thank E. Snelders and J. Michiels for their logistical support, the lab technicians of the Laboratory of Experimental Medicine and Pediatrics and L. Heyndrickx of the Institute of Tropical Medicine for the sample processing and P. Moons from Biobank Antwerp for his technical support. Special thanks to all the kidney transplant recipients, dialysis patients and control patients who made this study possible. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.rights | 2022 Elsevier B.V. All rights reserved. | - |
dc.subject.other | Antibodies | - |
dc.subject.other | Human leukocyte antigen (HLA) | - |
dc.subject.other | Minor antigen | - |
dc.subject.other | SARS-CoV-2 | - |
dc.subject.other | Vaccination | - |
dc.title | SARS-CoV-2 mRNA vaccination is not associated with the induction of anti-HLA or non-HLA antibodies | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 74 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Wijtvliet, VPWM (corresponding author), Antwerp Univ Hosp, Dept Nephrol & Hypertens, Drie Eikenstr 655, B-2650 Edegem, Belgium. | - |
dc.description.notes | veerle.wijtvliet@uantwerpen.be | - |
local.publisher.place | RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 101670 | - |
dc.identifier.doi | 10.1016/j.trim.2022.101670 | - |
dc.identifier.pmid | 35835296 | - |
dc.identifier.isi | 000835335500014 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Wijtvliet, Veerle P. W. M.; De Winter, Benedicte Y.; Massart, Annick; Hellemans, Rachel; Claas, Frans H. J.; Abramowicz, Daniel; Ledeganck, Kristien J.] Univ Antwerp, Lab Expt Med & Pediat, Edegem, Belgium. | - |
local.description.affiliation | [Wijtvliet, Veerle P. W. M.; De Winter, Benedicte Y.; Massart, Annick; Hellemans, Rachel; Claas, Frans H. J.; Abramowicz, Daniel; Ledeganck, Kristien J.] Univ Antwerp, Infla Med Ctr Excellence, Edegem, Belgium. | - |
local.description.affiliation | [Wijtvliet, Veerle P. W. M.; Massart, Annick; Hellemans, Rachel; Abramowicz, Daniel] Antwerp Univ Hosp, Dept Nephrol & Hypertens, Drie Eikenstr 655, B-2650 Edegem, Belgium. | - |
local.description.affiliation | [Verheyden, Sonja; Depreter, Barbara] Univ Ziekenhuis Brussel UZ Brussel, Dept Hematol, HLA & Mol Hematol Lab, Brussels, Belgium. | - |
local.description.affiliation | [Heylen, Christine; Coeman, Elke] Immucor Inc, Norcross, GA USA. | - |
local.description.affiliation | [Abrams, Steven] Univ Antwerp, Global Hlth Inst, Dept Family Med & Populat Hlth, Antwerp, Belgium. | - |
local.description.affiliation | [Abrams, Steven] Hasselt Univ, Data Sci Inst, I BioStat, Diepenbeek, Belgium. | - |
local.description.affiliation | [Pipeleers, Lissa; Wissing, Karl Martin] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Dept Nephrol, Brussels, Belgium. | - |
local.description.affiliation | [Claas, Frans H. J.] Leiden Univ, Med Ctr, Dept Immunol, Leiden, Netherlands. | - |
local.description.affiliation | [Arien, Kevin K.] Inst Trop Med, Dept Biomed Sci, Antwerp, Belgium. | - |
local.description.affiliation | [Arien, Kevin K.] Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2023 | - |
item.accessRights | Open Access | - |
item.fullcitation | Wijtvliet, Veerle P. W. M.; Verheyden, Sonja; Depreter, Barbara; Heylen, Christine; Coeman, Elke; ABRAMS, Steven; De Winter, Benedicte Y.; Massart, Annick; Hellemans , Rachel; Pipeleers, Lissa; Claas, Frans H. J.; Arien, Kevin K.; Wissing, Karl Martin; Abramowicz, Daniel & Ledeganck, Kristien J. (2022) SARS-CoV-2 mRNA vaccination is not associated with the induction of anti-HLA or non-HLA antibodies. In: TRANSPLANT IMMUNOLOGY, 74 (Art N° 101670). | - |
item.contributor | Wijtvliet, Veerle P. W. M. | - |
item.contributor | Verheyden, Sonja | - |
item.contributor | Depreter, Barbara | - |
item.contributor | Heylen, Christine | - |
item.contributor | Coeman, Elke | - |
item.contributor | ABRAMS, Steven | - |
item.contributor | De Winter, Benedicte Y. | - |
item.contributor | Massart, Annick | - |
item.contributor | Hellemans , Rachel | - |
item.contributor | Pipeleers, Lissa | - |
item.contributor | Claas, Frans H. J. | - |
item.contributor | Arien, Kevin K. | - |
item.contributor | Wissing, Karl Martin | - |
item.contributor | Abramowicz, Daniel | - |
item.contributor | Ledeganck, Kristien J. | - |
crisitem.journal.issn | 0966-3274 | - |
crisitem.journal.eissn | 1878-5492 | - |
Appears in Collections: | Research publications |
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SARS-CoV-2 mRNA vaccination is not associated with the induction of anti-HLA or non-HLA antibodies.pdf Restricted Access | Published version | 887.44 kB | Adobe PDF | View/Open Request a copy |
SARS.pdf | Peer-reviewed author version | 982.11 kB | Adobe PDF | View/Open |
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