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http://hdl.handle.net/1942/38043
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DC Field | Value | Language |
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dc.contributor.author | STEVENS, Sjoerd | - |
dc.contributor.author | Hendrickx, Paul | - |
dc.contributor.author | Snijders, Tim | - |
dc.contributor.author | LAMBRICHTS, Ivo | - |
dc.contributor.author | STESSEL, Bjorn | - |
dc.contributor.author | Dubois, Jasperina | - |
dc.contributor.author | van Loon, Luc J. C. | - |
dc.contributor.author | VANDENABEELE, Frank | - |
dc.contributor.author | AGTEN, Anouk | - |
dc.date.accessioned | 2022-09-12T10:16:38Z | - |
dc.date.available | 2022-09-12T10:16:38Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2022-08-17T12:38:46Z | - |
dc.identifier.citation | Applied sciences (Basel), 12 (14) (Art N° 7310) | - |
dc.identifier.uri | http://hdl.handle.net/1942/38043 | - |
dc.description.abstract | Many critically ill patients infected with SARS-CoV-2 have been submitted to an intensive care unit (ICU). Patients with a SARS-CoV-2 infection that survive critical illness are confronted with months of physical impairments. To maximize recovery, it is important to understand the musculoskeletal involvement in critically ill patients infected with SARS-CoV-2. The aim of the present study was to assess the myocellular changes in SARS-CoV-2 patients that occur throughout the first week of ICU admission. In n = 22 critically ill patients infected with SARS-CoV-2, a biopsy sample from the vastus lateralis muscle was obtained at day 1-3 and day 5-8 following ICU admission. Fluorescence microscopy was used to assess type I and type II muscle fiber size and distribution, myonuclear content, and muscle tissue capillarization. Transmission electron microscopy was used to support quantitative data at an ultrastructural level. Changes in type I and type II muscle fiber size showed large inter-individual variation. The average change in type I fiber size was +309 +/- 1834 mu m(2), ranging from -2129 mu m(2) (-31%) to +3375 mu m(2) (+73%). The average change in type II fiber size was -224 +/- 1256 mu m(2), ranging from -1410 mu m(2) (-36%) to +2592 mu m(2) (+48%). Ultrastructural observations showed myofibrillar and hydropic degeneration, and fiber necrosis. This study shows that ICU patients admitted with SARS-CoV-2 suffer from substantial muscle fiber damage during ICU admission. These results are a call for action towards more specialized rehabilitation programs for patients admitted to the ICU with SARS-CoV-2 infection. | - |
dc.description.sponsorship | We would like to thank all patients who suffered from a severe SARS-CoV-2 infection, requiring ICU admission, and their families, for their contributions to our knowledge on COVID-19. We would like express our thanks to the staff of the intensive care unit (ICU) of the Jessa Hospital Hasselt. We would like to express our gratitude to Erika Wisanto (pathologist, Jessa Hospital), Marc Jans (lab technician, Hasselt University), and Janneau van Kranenburg (lab technician, Maastricht University). | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | - |
dc.subject.other | severe acute respiratory syndrome virus | - |
dc.subject.other | skeletal muscles | - |
dc.subject.other | sepsis | - |
dc.subject.other | respiratory distress syndrome | - |
dc.subject.other | critical illness | - |
dc.title | Skeletal Muscles of Patients Infected with SARS-CoV-2 Develop Severe Myofiber Damage upon One Week of Admission on the Intensive Care Unit | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 14 | - |
dc.identifier.volume | 12 | - |
local.format.pages | 18 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Vandenabeele, F; Agten, A (corresponding author), Hasselt Univ, Fac Rehabil Sci & Physiotherapy, Rehabil Res Ctr, B-3590 Diepenbeek, Belgium.; Agten, A (corresponding author), Maastricht Univ, Fac Hlth Med & Life Sci, Dept Human Anat & Embryol, NL-6229 ER Maastricht, Netherlands. | - |
dc.description.notes | sjoerd.stevens@uhasselt.be; paul.hendrickx@student.kuleuven.be; | - |
dc.description.notes | tim.snijders@maastrichtuniversity.nl; ivo.lambrichts@uhasselt.be; | - |
dc.description.notes | bjorn.stessel@jessazh.be; jasperina.dubois@jessazh.be; | - |
dc.description.notes | l.vanloon@maastrichtuniversity.nl; frank.vandenabeele@uhasselt.be; | - |
dc.description.notes | anouk.agten@uhasselt.be | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 7310 | - |
dc.identifier.doi | 10.3390/app12147310 | - |
dc.identifier.isi | 000831921700001 | - |
dc.contributor.orcid | van Loon, Luc J.C./0000-0002-6768-9231; Lambrichts, | - |
dc.contributor.orcid | Ivo/0000-0001-7520-0021 | - |
local.provider.type | wosris | - |
local.description.affiliation | [Stevens, Sjoerd; Vandenabeele, Frank; Agten, Anouk] Hasselt Univ, Fac Rehabil Sci & Physiotherapy, Rehabil Res Ctr, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Stevens, Sjoerd; Snijders, Tim; van Loon, Luc J. C.] Maastricht Univ, Fac Hlth Med & Life Sci, NUTRIM Sch Nutr & Translat Res Metab, Dept Human Biol, NL-6229 ER Maastricht, Netherlands. | - |
local.description.affiliation | [Hendrickx, Paul; Stessel, Bjorn; Dubois, Jasperina] Jessa Hosp, Dept Anaesthesiol, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Lambrichts, Ivo; Stessel, Bjorn] Hasselt Univ, Fac Med & Life Sci, Biomed Res Inst, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Agten, Anouk] Maastricht Univ, Fac Hlth Med & Life Sci, Dept Human Anat & Embryol, NL-6229 ER Maastricht, Netherlands. | - |
local.uhasselt.international | yes | - |
item.accessRights | Open Access | - |
item.validation | ecoom 2023 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | STEVENS, Sjoerd; Hendrickx, Paul; Snijders, Tim; LAMBRICHTS, Ivo; STESSEL, Bjorn; Dubois, Jasperina; van Loon, Luc J. C.; VANDENABEELE, Frank & AGTEN, Anouk (2022) Skeletal Muscles of Patients Infected with SARS-CoV-2 Develop Severe Myofiber Damage upon One Week of Admission on the Intensive Care Unit. In: Applied sciences (Basel), 12 (14) (Art N° 7310). | - |
item.contributor | STEVENS, Sjoerd | - |
item.contributor | Hendrickx, Paul | - |
item.contributor | Snijders, Tim | - |
item.contributor | LAMBRICHTS, Ivo | - |
item.contributor | STESSEL, Bjorn | - |
item.contributor | Dubois, Jasperina | - |
item.contributor | van Loon, Luc J. C. | - |
item.contributor | VANDENABEELE, Frank | - |
item.contributor | AGTEN, Anouk | - |
crisitem.journal.eissn | 2076-3417 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Skeletal Muscles of Patients Infected with SARS-CoV-2 Develop Severe Myofiber Damage upon One Week of Admission on the Intensive Care Unit.pdf | Published version | 8.33 MB | Adobe PDF | View/Open |
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