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Title: | Predicting 6-minute walking test outcomes in patients with chronic obstructive pulmonary disease without physical performance measures | Authors: | Romero, Daniel Blanco-Almazan, Dolores Groenendaal, Willemijn Lijnen, Lien Smeets, Christophe RUTTENS, David Catthoor, Francky Jane, Raimon |
Issue Date: | 2022 | Publisher: | ELSEVIER IRELAND LTD | Source: | Computer methods and programs in biomedicine (Print), 225 (Art N° 107020) | Abstract: | Background and Objective: Chronic obstructive pulmonary disease (COPD) requires a multifactorial assess-ment, evaluating the airflow limitation and symptoms of the patients. The 6-min walk test (6MWT) is commonly used to evaluate the functional exercise capacity in these patients. This study aims to propose a novel predictive model of the major 6MWT outcomes for COPD assessment, without physical perfor-mance measurements. Methods: Cardiopulmonary and clinical parameters were obtained from fifty COPD patients. These pa-rameters were used as inputs of a Bayesian network (BN), which integrated three multivariate models including the 6-min walking distance (6MWD), the maximum HR (HRmax) after the walking, and the HR decay 3 min after (HRR3). The use of BN allows the assessment of the patients' status by predicting the 6MWT outcomes, but also inferring disease severity parameters based on actual patient's 6MWT out-comes. Results: Firstly, the correlation obtained between the estimated and actual 6MWT measures was strong ( R = 0.84, MAPE = 8.10% for HRmax) and moderate ( R = 0.58, MAPE = 15.43% for 6MWD and R = 0.58, MAPE = 32.49% for HRR3), improving the classical methods to estimate 6MWD. Secondly, the classifica-tion of disease severity showed an accuracy of 78.3% using three severity groups, which increased up to 84.4% for two defined severity groups. Conclusions: We propose a powerful two-way assessment tool for COPD patients, capable of predicting 6MWT outcomes without the need for an actual walking exercise. This model-based tool opens the way to implement a continuous monitoring system for COPD patients at home and to provide more personal-ized care. (c) 2022 The Authors. Published by Elsevier B.V. | Notes: | Romero, D (corresponding author), Univ Politecn Catalunya BarcelonaTech UPC, Barcelona 08019, Spain.; Romero, D (corresponding author), Inst Bioengn Catalonia IBEC, BIST, Barcelona 08019, Spain.; Romero, D (corresponding author), Biomed Res Networking Ctr Bioengn, Biomat & Nanomed CIBER BBN, Madrid 28029, Spain. dromero@ibecbarcelona.eu |
Keywords: | 6MWT;Wearables;Physical capacity;COPD;Bayesian networks | Document URI: | http://hdl.handle.net/1942/38087 | ISSN: | 0169-2607 | e-ISSN: | 1872-7565 | DOI: | 10.1016/j.cmpb.2022.107020 | ISI #: | 000838912700008 | Rights: | 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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Predicting 6-minute walking test outcomes in patients with chronic obstructive pulmonary disease without physical performance measures.pdf | 1.85 MB | Adobe PDF | View/Open |
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